Search Results - "Adelman, John"

SK2 Channel Modulation Contributes to Compartment-Specific Dendritic Plasticity in Cerebellar Purkinje Cells by Ohtsuki, Gen, Piochon, Claire, Adelman, John P., Hansel, Christian

“…Small-conductance Ca2+-activated K+ channels (SK channels) modulate excitability and curtail excitatory postsynaptic potentials (EPSPs) in neuronal dendrites…”
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Small-conductance Ca2+-activated K+ channels: form and function by Adelman, John P, Maylie, James, Sah, Pankaj

“…Small-conductance Ca(2+)-activated K(+) channels (SK channels) are widely expressed throughout the central nervous system. These channels are activated solely…”
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In memoriam Peter H. Seeburg by Adelman, John P.

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Activity-Dependent Plasticity of Spike Pauses in Cerebellar Purkinje Cells by Grasselli, Giorgio, He, Qionger, Wan, Vivian, Adelman, John P., Ohtsuki, Gen, Hansel, Christian

“…The plasticity of intrinsic excitability has been described in several types of neurons, but the significance of non-synaptic mechanisms in brain plasticity…”
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SK channels and calmodulin by Adelman, John P

“…Calcium ions are Nature's most widely used signaling mechanism, mediating communication between pathways at virtually every physiological level. Ion channels…”
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Site-directed RNA repair of endogenous Mecp2 RNA in neurons by Sinnamon, John R., Kim, Susan Y., Corson, Glen M., Song, Zhen, Nakai, Hiroyuki, Adelman, John P., Mandel, Gail

“…Rett syndrome (RTT) is a debilitating neurological disorder caused by mutations in the gene encoding the transcription factor Methyl CpG Binding Protein 2…”
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SK2 channel plasticity contributes to LTP at Schaffer collateral-CA1 synapses by Luján, Rafael, Lin, Mike T, Adelman, John P, Maylie, James, Watanabe, Masahiko

“…Long-term potentiation (LTP) of synaptic strength at Schaffer collateral synapses has largely been attributed to changes in the number and biophysical…”
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The Ca(V)3.3 calcium channel is the major sleep spindle pacemaker in thalamus by Astori, Simone, Wimmer, Ralf D, Prosser, Haydn M, Corti, Corrado, Corsi, Mauro, Liaudet, Nicolas, Volterra, Andrea, Franken, Paul, Adelman, John P, Lüthi, Anita

“…Low-threshold (T-type) Ca(2+) channels encoded by the Ca(V)3 genes endow neurons with oscillatory properties that underlie slow waves characteristic of the…”
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Control of KCa Channels by Calcium Nano/Microdomains by Fakler, Bernd, Adelman, John P.

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New sites of action for GIRK and SK channels by Luján, Rafael, Maylie, James, Adelman, John P

“…GIRK and SK channels, two families of voltage-independent K + channels, have recently been described at synaptic as well as extrasynaptic sites. Luján and…”
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Organization and Regulation of Small Conductance Ca2+-activated K+ Channel Multiprotein Complexes by Allen, Duane, Fakler, Bernd, Maylie, James, Adelman, John P

“…Small conductance Ca2+-activated K+ channels (SK channels) are complexes of four alpha pore-forming subunits each bound by calmodulin (CaM) that mediate Ca2+…”
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Genetic Deficit of SK3 and IK1 Channels Disrupts the Endothelium-Derived Hyperpolarizing Factor Vasodilator Pathway and Causes Hypertension by BRÄHLER, Sebastian, KAISTHA, Anuradha, BOND, Chris T, ADELMAN, John P, WULFF, Heike, DE WIT, Cor, HOYER, Joachim, KÖHLER, Ralf, SCHMIDT, Volker J, WÖLFLE, Stephanie E, BUSCH, Christoph, KAISTHA, Brajesh P, KACIK, Michael, HASENAU, Anna-Lena, GRGIC, Ivica, HAN SI

“…It has been proposed that activation of endothelial SK3 (K(Ca)2.3) and IK1 (K(Ca)3.1) K+ channels plays a role in the arteriolar dilation attributed to an…”
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Presynaptic maturation in auditory hair cells requires a critical period of sensory-independent spiking activity by Johnson, Stuart L., Kuhn, Stephanie, Franz, Christoph, Ingham, Neil, Furness, David N., Knipper, Marlies, Steel, Karen P., Adelman, John P., Holley, Matthew C., Marcotti, Walter

“…The development of neural circuits relies on spontaneous electrical activity that occurs during immature stages of development. In the developing mammalian…”
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Sustaining sleep spindles through enhanced SK2-channel activity consolidates sleep and elevates arousal threshold by Wimmer, Ralf D, Astori, Simone, Bond, Chris T, Rovó, Zita, Chatton, Jean-Yves, Adelman, John P, Franken, Paul, Lüthi, Anita

“…Sleep spindles are synchronized 11-15 Hz electroencephalographic (EEG) oscillations predominant during nonrapid-eye-movement sleep (NREMS). Rhythmic bursting…”
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T-type Ca2+ channels, SK2 channels and SERCAs gate sleep-related oscillations in thalamic dendrites by Cueni, Lucius, Canepari, Marco, Luján, Rafael, Emmenegger, Yann, Watanabe, Masahiko, Bond, Chris T, Franken, Paul, Adelman, John P, Lüthi, Anita

“…T-type Ca 2+ channels (T channels) underlie rhythmic burst discharges during neuronal oscillations that are typical during sleep. However, the Ca 2+ -dependent…”
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Endothelial SK3 channel-associated Ca2+ microdomains modulate blood pressure by Yap, Fui C, Weber, David S, Taylor, Mark S, Townsley, Mary I, Comer, Brian S, Maylie, James, Adelman, John P, Lin, Mike T

“…Activation of vascular endothelial small- (KCa2.3, SK3) or intermediate- (KCa3.1, IK1) conductance Ca(2+)-activated potassium channels induces vasorelaxation…”
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Sensing Muscle Ischemia: Coincident Detection of Acid and ATP via Interplay of Two Ion Channels by Birdsong, William T., Fierro, Leonardo, Williams, Frank G., Spelta, Valeria, Naves, Ligia A., Knowles, Michelle, Marsh-Haffner, Josephine, Adelman, John P., Almers, Wolfhard, Elde, Robert P., McCleskey, Edwin W.

“…Ischemic pain—examples include the chest pain of a heart attack and the leg pain of a 30 s sprint—occurs when muscle gets too little oxygen for its metabolic…”
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Ovarian hormone deficiency reduces intrinsic excitability and abolishes acute estrogen sensitivity in hippocampal CA1 pyramidal neurons by Wu, Wendy W, Adelman, John P, Maylie, James

“…Premature and uncompensated loss of ovarian hormones following ovariectomy (OVX) elevates the risks of cognitive impairment and dementia. These risks are…”
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F-box protein-32 down-regulates small-conductance calcium-activated potassium channel 2 in diabetic mouse atria by Ling, Tian-You, Yi, Fu, Lu, Tong, Wang, Xiao-Li, Sun, Xiaojing, Willis, Monte S., Wu, Li-Qun, Shen, Win-Kuang, Adelman, John P., Lee, Hon-Chi

“…Diabetes mellitus (DM) is an independent risk factor for atrial fibrillation, but the underlying ionic mechanism for this association remains unclear. We…”
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PARP6 is a Regulator of Hippocampal Dendritic Morphogenesis by Huang, Jeffrey Y., Wang, Kang, Vermehren-Schmaedick, Anke, Adelman, John P., Cohen, Michael S.

“…Mono-ADP-ribosylation (MARylation) of mammalian proteins was first described as a post-translational modification catalyzed by bacterial toxins. It is now…”
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