Search Results - "Adelakun, Niyi"

Prion protein pathology in Ubiquilin 2 models of ALS by Le, Nhat T., Chu, Nam, Joshi, Gunjan, Higgins, Nicole R., Nebie, Ouada, Adelakun, Niyi, Butts, Marie, Monteiro, Mervyn J.

“…Mutations in UBQLN2 cause ALS and frontotemporal dementia (FTD). The pathological signature in UBQLN2 cases is deposition of highly unusual types of inclusions…”
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Polypharmacology of some medicinal plant metabolites against SARS-CoV-2 and host targets: Molecular dynamics evaluation of NSP9 RNA binding protein by Bandyopadhyay, Suritra, Abiodun, Omobolanle Abimbola, Ogboo, Blessing Chinweotito, Kola-Mustapha, Adeola Tawakalitu, Attah, Emmanuel Ifeanyi, Edemhanria, Lawrence, Kumari, Ankita, Jaganathan, Ravindran, Adelakun, Niyi S.

“…Medicinal plants as rich sources of bioactive compounds are now being explored for drug development against COVID-19. 19 medicinal plants known to exhibit…”
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T‐705‐modified ssRNA in complex with Lassa virus nucleoprotein exhibits nucleotide splaying and increased water influx into the RNA‐binding pocket by Omotuyi, Olaposi I., Nash, Oyekanmi, Safronetz, David, Ojo, Ayodeji A., Ogunwa, Tomisin H., Adelakun, Niyi S.

“…Lassa virus infection is clinically characterized by multiorgan failure in humans. Without an FDA‐approved vaccine, ribavirin is the frontline drug for the…”
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Induced Fit Docking and Automated QSAR Studies Reveal the ER-α Inhibitory Activity of Cannabis sativa in Breast Cancer by Kikiowo, Babatomiwa, Ogunleye, Adewale J, Iwaloye, Opeyemi, Ijatuyi, Taiwo T, Adelakun, Niyi S, Alashe, Wasiu O

“…Breast Cancer (BC), a common fatal disease and the deadliest cancer next to lung cancer, is characterized by an abnormal growth of cells in the tissues of the…”
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Molecular docking analysis of phyto-constituents from Cannabis sativa with pfDHFR by David, Temitope I, Adelakun, Niyi S, Omotuyi, Olaposi I, Metibemu, Damilohun S, Ekun, Oluwafemi E, Eniafe, Gabriel O, Inyang, Olumide K, Adewumi, Bamidele, Enejoh, Ojochenemi A, Owolabi, Raymond T, Oribamise, Eunice I

“…Available antimalarial drugs have been associated with numerous side effects, which include skin rashes and myelo-suppression. Therefore, it is of interest to…”
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Flavones scaffold of Chromolaena odorata as a potential xanthine oxidase inhibitor: Induced Fit Docking and ADME studies by Kikiowo, Babatomiwa, Ogunleye, Adewale Joseph, Inyang, Olumide Kayode, Adelakun, Niyi Samuel, Omotuyi, Olaposi Idowu, Metibemu, Damilohun Samuel, David, Temitope Israel, Oludoyi, Oluwatoyin Olajide, Ijatuyi, Taiwo Tolulope

“…Introduction: Gout is a type of painful inflammation initiated by the interactions between monosodium urate crystals and connective tissue. Xanthine oxidase…”
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Chromolaena odorata flavonoids attenuate experimental nephropathy: Involvement of pro-inflammatory genes downregulation by Omotuyi, Olaposi Idowu, Nash, Oyekanmi, Enejoh, Ojochenemi Aladi, Oribamise, Eunice Iyanuoluwa, Adelakun, Niyi Samuel

“…[Display omitted] •Exposure of Wistar rats to Streptozotocin (STZ) causes acute kidney injury and loss of nephron functions.•STZ-induced kidney injury is…”
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Agemone mexicana flavanones; apposite inverse agonists of the β2-adrenergic receptor in asthma treatment by Eniafe, Gabriel O, Metibemu, Damilohun S, Omotuyi, Olaposi I, Ogunleye, Adewale J, Inyang, Olumide K, Adelakun, Niyi S, Adeniran, Yakubu O, Adewumi, Bamidele, Enejoh, Ojochenemi A, Osunmuyiwa, Joseph O, Shodehinde, Sidiqat A, Oyeneyin, Oluwatoba E

“…Asthma is an inflammatory disease of the airway that poses a major threat to human health. With increase industrialization in the developed and developing…”
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Analyzing protein posttranslational modifications using enzyme-catalyzed expressed protein ligation by Adelakun, Niyi, Parrish, Jordan, Chu, Nam

“…Expressed protein ligation (EPL) allows for the attachment of a synthetic peptide into the N- or C-terminus of a recombinant protein fragment to generate a…”
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Discovery of new promising USP14 inhibitors: computational evaluation of the thumb-palm pocket by Adelakun, Niyi, Obaseki, Ikponwmosa, Adeniyi, Ayobami, Fapohunda, Oluwaseun, Obaseki, Eseiwi, Omotuyi, Olaposi

“…Ubiquitin-specific protease 14 (USP14) is a member of the deubiquitinating enzymes (DUBs) involved in disrupting the ubiquitin-proteasome regulation system,…”
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Molecular Docking and 3D Qsar Studies of C000000956 as a Potent Inhibitor of Bace-1 by Joseph, Ogunleye Adewale, Babatomiwa, Kikiowo, Niyi, Adelakun, Olaposi, Omotuyi, Olumide, Inyang

“…BACE-1 is an aspartate protease that is responsible for the proteolysis of amyloid precursor proteins (APP) into beta-amyloid (Aβ), a neurotoxic peptide in…”
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Aframomum melegueta secondary metabolites exhibit polypharmacology against SARS‐CoV‐2 drug targets: in vitro validation of furin inhibition by Omotuyi, I. Olaposi, Nash, Oyekanmi, Ajiboye, Basiru O., Olumekun, Victor O., Oyinloye, Babatunji E., Osuntokun, Oludare T., Olonisakin, Adebisi, Ajayi, A. Olajide, Olusanya, Olasehinde, Akomolafe, Funmilola S., Adelakun, Niyi

“…COVID‐19 pandemic is currently decimating the world's most advanced technologies and largest economies and making its way to the continent of Africa. Weak…”
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'Arty-farty'? Hands off new-look TES: letters by Adelakun, Niyi

“…When I realised after a few minutes how the pictures fit in with the leading article ("The many and the few", 21 October), the delayed gratification made me…”
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