Search Results - "Adediran, S."

Kinetic Evidence for a Second Ligand Binding Site on Streptococcus pneumoniae Penicillin-Binding Protein 2x by Adediran, S. A, Sarkar, Kumar Subarno, Pratt, R. F

“…High molecular mass penicillin-binding proteins (PBPs, DD-peptidases) of class B, such as Streptococcus pneumoniae PBP2x, catalyze the cross-linking of…”
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Detection of an enzyme isomechanism by means of the kinetics of covalent inhibition by Adediran, S.A., Morrison, Michael J., Pratt, R.F.

“…Turnover of substrates by many enzymes involves free enzyme forms that differ from the stable form of the enzyme in the absence of substrate. These enzyme…”
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Interactions of “Bora-Penicilloates” with Serine β‑Lactamases and DD-Peptidases by Dzhekieva, Liudmila, Adediran, S. A, Pratt, R. F

“…Specific boronic acids are generally powerful tetrahedral intermediate/transition state analogue inhibitors of serine amidohydrolases. This group of enzymes…”
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A New Covalent Inhibitor of Class C β‑Lactamases Reveals Extended Active Site Specificity by Tilvawala, Ronak, Cammarata, Michael, Adediran, S. A, Brodbelt, Jennifer S, Pratt, R. F

“…O-Aryloxycarbonyl hydroxamates have previously been shown to efficiently inactivate class C β-lactamases by cross-linking serine and lysine residues in the…”
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Penicillin acylase and O-aryloxycarbonyl hydroxamates: Two acyl-enzymes, one leading to hydrolysis, the other to inactivation by Adediran, S.A., Pratt, R.F.

“…O-Aryloxycarbonyl hydroxamates have previously been shown to covalently inactivate serine/amine amidohydrolases such as class C β-lactamases and a N-terminal…”
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Specificity of extended O-aryloxycarbonyl hydroxamates as inhibitors of a class C β-lactamase by Malico, Alexandra A., Dave, K., Adediran, S.A., Pratt, R.F.

“…[Display omitted] Class C β-lactamases have previously been shown to be efficiently inactivated by O-aryloxycarbonyl hydroxamates…”
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Substrate Specificity of Low-Molecular Mass Bacterial dd-Peptidases by Nemmara, Venkatesh V, Dzhekieva, Liudmila, Subarno Sarkar, Kumar, Adediran, S. A, Duez, Colette, Nicholas, Robert A, Pratt, R. F

“…The bacterial dd-peptidases or penicillin-binding proteins (PBPs) catalyze the formation and regulation of cross-links in peptidoglycan biosynthesis. They are…”
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β-Ketophosphonates as β-lactamase inhibitors: Intramolecular cooperativity between the hydrophobic subsites of a class D β-lactamase by Perumal, Senthil K., Adediran, S.A., Pratt, R.F.

“…A series of aryl and arylmethyl β-aryl-β-ketophosphonates have been prepared as potential β-lactamase inhibitors. These compounds, as fast, reversible,…”
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Dual Substrate Specificity of Bacillus subtilis PBP4a by Nemmara, Venkatesh V, Adediran, S. A, Dave, Kinjal, Duez, Colette, Pratt, R. F

“…Bacterial dd-peptidases are the targets of the β-lactam antibiotics. The sharp increase in bacterial resistance toward these antibiotics in recent years has…”
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Comparison of cardiorespiratory and anaesthetic effect of alfaxalone or propofol in dogs premedicated with acepromazine-buprenorphine by Adediran, S. O., Adetunji, A.

“…The study compared the cardiorespiratory and anaesthetic effects of alfaxalone or propofol for total intravenous anaesthesia (TIVA) in dogs premedicated with…”
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Comparative evaluation of a new lactation curve model for pasture-based Holstein-Friesian dairy cows by Adediran, S A, Ratkowsky, D A, Donaghy, D J, Malau-Aduli, A E O

“…Fourteen lactation models were fitted to average and individual cow lactation data from pasture-based dairy systems in the Australian states of Victoria and…”
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Inhibition of dd-Peptidases by a Specific Trifluoroketone: Crystal Structure of a Complex with the Actinomadura R39 dd-Peptidase by Dzhekieva, Liudmila, Adediran, S. A, Herman, Raphael, Kerff, Frédéric, Duez, Colette, Charlier, Paulette, Sauvage, Eric, Pratt, R. F

“…Inhibitors of bacterial dd-peptidases represent potential antibiotics. In the search for alternatives to β-lactams, we have investigated a series of compounds…”
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Specificity and mechanism of mandelamide hydrolase catalysis by Adediran, S.A., Wang, Pan-Fen, Shilabin, Abbas G., Baron, Charles A., McLeish, Michael J., Pratt, R.F.

“…The best-studied amidase signature (AS) enzyme is probably fatty acid amide hydrolase (FAAH). Closely related to FAAH is mandelamide hydrolase (MAH), whose…”
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Empirical analysis of the effects of foreign direct investment inflows on Nigerian real economic growth: Implications for sustainable development goal-17 by Giwa, Babatunde A., George, Emmanuel O., Okodua, Henry, Adediran, Oluwasogo S.

“…Existing literature in modern macroeconomics is saturated with various studies on both the short and long run link between foreign direct investment (FDI) and…”
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Kinetics of Reactions of the Actinomadura R39 dd-Peptidase with Specific Substrates by Adediran, S. A, Kumar, Ish, Nagarajan, Rajesh, Sauvage, Eric, Pratt, R. F

“…The Actinomadura R39 dd-peptidase catalyzes the hydrolysis and aminolysis of a number of small peptides and depsipeptides. Details of its substrate specificity…”
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Efficacy and safety of xylazine-ketamine combination for immobilisation of captive African rock pythons (Python sebae) by Adediran, S. O., Jegede, H. O., Lawal, F. M., Amid, S. A., Abdulkadir, S. Z., Alimi, A. O., Ali­yu, A., Bolaji, M.

“…The African rock python is a cosmopolitan snake in Nigeria widely kept as a zoo animal and also in recreational facilities. There is need for chemical…”
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Is there any relationship between monetary policy tools and external credit-growth nexus in Nigeria? by Adediran, Oluwasogo S, George, Emmanuel O, Alege, Philip, Obasaju, Barnabas O

“…The Nigerian economy attracts abundance of foreign capital inflows and credit supply; hence, an adverse external credit shock might lead to a large decrease of…”
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Crossover inhibition as an indicator of convergent evolution of enzyme mechanisms: A β-lactamase and a N-terminal nucleophile hydrolase by Adediran, S.A., Lin, G., Pelto, R.B., Pratt, R.F.

“…► A cross-check of two inhibitors shows both inhibit a β-lactamase and a proteasome. ► Similar inhibition mechanisms and similar products. ► Active site…”
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Inhibition of Serine β-Lactamases by Vanadate−Catechol Complexes by Adediran, S. A, Pratt, R. F

“…All three classes of serine β-lactamases are inhibited at micromolar levels by 1:1 complexes of catechols with vanadate. Vanadate reacts with catechols at…”
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Crystal Structure of the Bacillus subtilis Penicillin-binding Protein 4a, and its Complex with a Peptidoglycan Mimetic Peptide by Sauvage, Eric, Duez, Colette, Herman, Raphaël, Kerff, Frédéric, Petrella, Stephanie, Anderson, John W., Adediran, S.A., Pratt, R.F., Frère, Jean-Marie, Charlier, Paulette

“…The genome of Bacillus subtilis encodes 16 penicillin-binding proteins (PBPs) involved in the synthesis and/or remodelling of the peptidoglycan during the…”
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