Search Results - "Adedara, Isaac A"

Benzo(a)pyrene induces oxidative stress, pro-inflammatory cytokines, expression of nuclear factor-kappa B and deregulation of wnt/beta-catenin signaling in colons of BALB/c mice by Ajayi, Babajide O., Adedara, Isaac A., Farombi, Ebenezer O.

“…The incidence of colonic toxicity has been epidemiologically linked to the consumption of foods contaminated with benzo(a)pyrene (B[a]P). The present study…”
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Induction of aggression and anxiety-like responses by perfluorooctanoic acid is accompanied by modulation of cholinergic- and purinergic signaling-related parameters in adult zebrafish by Adedara, Isaac A., Souza, Thiele P., Canzian, Julia, Olabiyi, Ayodeji A., Borba, João V., Biasuz, Eduarda, Sabadin, Giovana R., Gonçalves, Falco L., Costa, Fabiano V., Schetinger, Maria R.C., Farombi, Ebenezer O., Rosemberg, Denis B.

“…Perfluorooctanoic acid (PFOA) is a contaminant of global concern owing to its prevalent occurrence in aquatic and terrestrial environments with potential…”
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Molecular mechanisms associated with the chemoprotective role of protocatechuic acid and its potential benefits in the amelioration of doxorubicin-induced cardiotoxicity: A review by Okpara, Edozie S., Adedara, Isaac A., Guo, Xiaohua, Klos, Matthew L., Farombi, Ebenezer O., Han, Shuxin

“…Since its discovery in the 1960 s, doxorubicin (DOX) has constantly elicited the broadest spectrum of cancerocidal activity against human cancers. However,…”
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Curcumin and Kolaviron Ameliorate Di‐n‐Butylphthalate‐Induced Testicular Damage in Rats by Farombi, Ebenezer Olatunde, Abarikwu, Sunday O., Adedara, Isaac A., Oyeyemi, Matthew O.

“…:  The present study was carried out to evaluate the ameliorative effects of kolaviron (a biflavonoid from the seeds of Garcinia kola) and curcumin (from the…”
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Utility of cockroach as a model organism in the assessment of toxicological impacts of environmental pollutants by Adedara, Isaac A., Mohammed, Khadija A., Da-Silva, Oluwatobiloba F., Salaudeen, Faoziyat A., Gonçalves, Falco L.S., Rosemberg, Denis B., Aschner, Michael, Rocha, Joao B.T., Farombi, Ebenezer O.

“…•Bio-monitoring of environmental health is of great global interest.•The utility of the laboratory cockroach as a model organism in toxicology was…”
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Dietary supplementation of ginger and turmeric improves reproductive function in hypertensive male rats by Akinyemi, Ayodele Jacob, Adedara, Isaac A, Thome, Gustavo Roberto, Morsch, Vera Maria, Rovani, Monique Tomazele, Mujica, Lady Katerine Serrano, Duarte, Thiago, Duarte, Marta, Oboh, Ganiyu, Schetinger, Maria Rosa Chitolina

“…Ginger [ Roscoe (Zingiberaceae)] and turmeric [ Linn (Zingiberaceae)] rhizomes have been reportedly used in folk medicine for the treatment of hypertension…”
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6-Gingerol delays tumorigenesis in benzo[a]pyrene and dextran sulphate sodium-induced colorectal cancer in mice by Farombi, Ebenezer O., Ajayi, Babajide O., Adedara, Isaac A.

“…Colorectal cancer (CRC) has been linked to dietary consumption of benzo[a]pyrene (B[a]P). 6-Gingerol (6-G), a component of ginger has been reported to possess…”
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Pretreatment with taurine prevented brain injury and exploratory behaviour associated with administration of anticancer drug cisplatin in rats by Owoeye, Olatunde, Adedara, Isaac A., Farombi, Ebenezer O.

“…The neurotoxicity associated with cisplatin treatment is one of the major side effects compromising the efficacy of the anti-cancer treatment. The present…”
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Protocatechuic acid modulates reproductive dysfunction linked to furan exposure in rats by Owumi, Solomon E., Adedara, Isaac A., Farombi, Ebenezer O., Oyelere, Adegboyega K.

“…•Protocatechuic acid (PCA), a dietary polyphenol, elicits beneficial effects on male reproductive system.•PCA alleviated furan-mediated declines in sperm…”
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6-Gingerol abates benzo[a]pyrene-induced colonic injury via suppression of oxido-inflammatory stress responses in BALB/c mice by Ajayi, Babajide O., Adedara, Isaac A., Farombi, Ebenezer O.

“…Exposure to benzo[a]pyrene (BaP), the most toxic polycyclic aromatic hydrocarbon and a procarcinogen, is a global health concern which necessitates preventive…”
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Neurotoxicity of ochratoxin A: Molecular mechanisms and neurotherapeutic strategies by Obafemi, Blessing A., Adedara, Isaac A., Rocha, Joao B.T.

“…Data from epidemiological and experimental studies have evidenced that some chemical contaminants in food elicit their harmful effects by targeting the central…”
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Protocatechuic acid ameliorates neurobehavioral deficits via suppression of oxidative damage, inflammation, caspase-3 and acetylcholinesterase activities in diabetic rats by Adedara, Isaac A., Fasina, Opeyemi B., Ayeni, Modupe F., Ajayi, Olamide M., Farombi, Ebenezer O.

“…Clinical and experimental data have demonstrated that diabetes is associated with neurological complications. Protocatechuic acid (PCA) is a phenolic…”
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Gallic acid enhances reproductive function by modulating oxido-inflammatory and apoptosis mediators in rats exposed to aflatoxin-B1 by Owumi, Solomon E, Adedara, Isaac A, Akomolafe, Ayomide P, Farombi, Ebenezer O, Oyelere, Adegboyega K

“…Aflatoxin B1 (AFB1) is reported to elicit adverse reproductive outcomes in animals. Gallic acid (GA) is known to exhibit antioxidant and inflammatory…”
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Indole-3-propionic acid mitigates chlorpyrifos-mediated neurotoxicity by modulating cholinergic and redox-regulatory systems, inflammatory stress, apoptotic responses and DNA damage in rats by Owumi, Solomon E., Adedara, Isaac A., Oyelere, Adegboyega K.

“…This study probed the neuroprotective influence of indole-3-propionic acid (IPA) in rats exposed to chlorpyrifos (CPF) alone at 5 mg/kg body weight or…”
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Pharmacological Activity of 6‐Gingerol in Dextran Sulphate Sodium‐induced Ulcerative Colitis in BALB/c Mice by Ajayi, Babajide O, Adedara, Isaac A, Farombi, Ebenezer O

“…Gingerols are phenolic compounds in ginger (Zingiber officinale), which have been reported to exhibit antiinflammatory, antioxidant, and anticancer properties…”
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Dietary protocatechuic acid abrogates male reproductive dysfunction in streptozotocin-induced diabetic rats via suppression of oxidative damage, inflammation and caspase-3 activity by Adedara, Isaac A., Okpara, Edozie S., Busari, Esther O., Omole, Olubunmi, Owumi, Solomon E., Farombi, Ebenezer O.

“…Clinical and experimental studies demonstrated that reproductive dysfunction is a non-lethal complication of diabetes. Protocatechuic acid (PCA) reportedly…”
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Influence of furan and lead co-exposure at environmentally relevant concentrations on neurobehavioral performance, redox-regulatory system and apoptotic responses in rats by Owumi, Solomon E., Adedara, Isaac A., Otunla, Moses T., Owoeye, Olatunde

“…Furan and lead are contaminants of global concern due to the potential public health threat associated with their exposure. Herein, the neurobehavioral…”
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Neurotoxicity of furan in juvenile Wistar rats involves behavioral defects, microgliosis, astrogliosis and oxidative stress by Awogbindin, Ifeoluwa O., Ikeji, Cynthia N., Adedara, Isaac A., Farombi, Ebenezer O.

“…Evidence suggests that furan, a widespread environmental and food contaminant, causes liver toxicity and cancer, but its implications in the brain are not well…”
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Impairment of Hepatic and Renal Functions by 2,5-Hexanedione Is Accompanied by Oxidative Stress in Rats by Omoloja, Abiola A., Okwudi, Isioma J., Odion, Blessing E., Abolaji, Amos O., Adedara, Isaac A., Farombi, Ebenezer O.

“…2,5-Hexanedione (2,5-HD) is the toxic metabolite of n-hexane which is widely used as solvent in numerous industries. The present study elucidated the precise…”
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Dietary myricetin assuages atrazine-mediated hypothalamic-pituitary–testicular axis dysfunction in rats by Ikeji, Cynthia N., Adedara, Isaac A., Farombi, Ebenezer O.

“…Atrazine (ATZ) exposure is associated with reproductive dysfunction in both animals and humans. Myricetin, a flavonoid compound, is well documented for its…”
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