Search Results - "Adebayo, Adedeji K"

Oxygen tension-dependent variability in the cancer cell kinome impacts signaling pathways and response to targeted therapies by Adebayo, Adedeji K., Bhat-Nakshatri, Poornima, Davis, Christopher, Angus, Steven P., Erdogan, Cihat, Gao, Hongyu, Green, Nick, Kumar, Brijesh, Liu, Yunlong, Nakshatri, Harikrishna

“…Most cells in solid tumors are exposed to oxygen levels between 0.5% and 5%. We developed an approach that allows collection, processing, and evaluation of…”
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Modeling Preclinical Cancer Studies under Physioxia to Enhance Clinical Translation by Adebayo, Adedeji K, Nakshatri, Harikrishna

“…Oxygen (O2) plays a key role in cellular homeostasis. O2 levels are tightly regulated in vivo such that each tissue receives an optimal amount to maintain…”
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Nexus between PI3K/AKT and Estrogen Receptor Signaling in Breast Cancer by Khatpe, Aditi S, Adebayo, Adedeji K, Herodotou, Christopher A, Kumar, Brijesh, Nakshatri, Harikrishna

“…Signaling from estrogen receptor alpha (ERα) and its ligand estradiol (E2) is critical for growth of ≈70% of breast cancers. Therefore, several drugs that…”
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Single-nucleus chromatin accessibility and transcriptomic map of breast tissues of women of diverse genetic ancestry by Bhat-Nakshatri, Poornima, Gao, Hongyu, Khatpe, Aditi S, Adebayo, Adedeji K, McGuire, Patrick C, Erdogan, Cihat, Chen, Duojiao, Jiang, Guanglong, New, Felicia, German, Rana, Emmert, Lydia, Sandusky, George, Storniolo, Anna Maria, Liu, Yunlong, Nakshatri, Harikrishna

“…Single-nucleus analysis allows robust cell-type classification and helps to establish relationships between chromatin accessibility and cell-type-specific gene…”
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Mutant RAS-driven Secretome Causes Skeletal Muscle Defects in Breast Cancer by Wang, Ruizhong, Khatpe, Aditi S, Kumar, Brijesh, Mang, Henry Elmer, Batic, Katie, Adebayo, Adedeji K, Nakshatri, Harikrishna

“…Cancer-induced skeletal muscle defects differ in severity between individuals with the same cancer type. Cancer subtype-specific genomic aberrations are…”
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Tumor collection/processing under physioxia uncovers highly relevant signaling networks and drug sensitivity by Kumar, Brijesh, Adebayo, Adedeji K, Prasad, Mayuri, Capitano, Maegan L, Wang, Ruizhong, Bhat-Nakshatri, Poornima, Anjanappa, Manjushree, Simpson, Edward, Chen, Duojiao, Liu, Yunlong, Schilder, Jeanne M, Colter, Austyn B, Maguire, Callista, Temm, Constance J, Sandusky, George, Doud, Emma H, Wijeratne, Aruna B, Mosley, Amber L, Broxmeyer, Hal E, Nakshatri, Harikrishna

“…Preclinical studies of primary cancer cells are typically done after tumors are removed from patients or animals at ambient atmospheric oxygen (O , ~21%)…”
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Clofibrate, a PPAR‐α agonist, abrogates sodium fluoride‐induced neuroinflammation, oxidative stress, and motor incoordination via modulation of GFAP/Iba‐1/anti‐calbindin signaling pathways by Oyagbemi, Ademola A., Adebiyi, Olamide E., Adigun, Kabirat O., Ogunpolu, Blessing S., Falayi, Olufunke O., Hassan, Fasilat O., Folarin, Oluwabusayo R., Adebayo, Adedeji K., Adejumobi, Olumuyiwa A., Asenuga, Ebunoluwa R., Ola‐Davies, Olufunke E., Omobowale, Temidayo O., Olopade, James O., Saba, Adebowale B., Adedapo, Adeolu A., Nkadimeng, Sanah M., McGaw, Lyndy J., Oguntibeju, Oluwafemi O., Yakubu, Momoh A.

“…Fluoride is an environmental contaminant that is ubiquitously present in air, water, and soil. It is commonly added in minute quantity to drinking water,…”
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Characterisation of heart failure with normal ejection fraction in a tertiary hospital in Nigeria by Adebayo, Adedeji K, Adebiyi, Adewole A, Oladapo, Olulola O, Ogah, Okechukwu S, Aje, Akinyemi, Ojji, Dike B, Falase, Ayodele O

“…The study aimed to determine the frequency and characteristics of heart failure with normal EF in a native African population with heart failure. It was a…”
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Echocardiographic partition values and prevalence of left ventricular hypertrophy in hypertensive Nigerians by Adebiyi, Adewole A, Ogah, Okechukwu S, Aje, Akinyemi, Ojji, Dike B, Adebayo, Adedeji K, Oladapo, Olulola O, Falase, Ayodele O

“…Left ventricular hypertrophy (LVH) is a well known independent risk factor for cardiovascular events. It has been shown that combination of left ventricular…”
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Changes in left atrial dimension and function and left ventricular geometry in newly diagnosed untreated hypertensive subjects by Adebayo, Adedeji K, Oladapo, Olulola O, Adebiyi, Adewole A, Ogunleye, Olayinka O, Ogah, Okechukwu S, Ojji, Dike B, Aje, Akinyemi, Adeoye, Moshood A, Ochulor, Kenneth C, Enakpene, Evbu O, Falase, Ayodele O

“…BACKGROUNDIt is known that a spectrum of changes in structure, size and function of the different chambers of the heart occur in individuals with hypertension…”
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Blood pressure control and left ventricular hypertrophy in hypertensive Nigerians by Salako, Babatunde L, Ogah, Okechukwu S, Adebiyi, Adewole A, Oladapo, Olulola O, Aje, Akinyemi, Adebayo, Adedeji K, Ojji, Dike B, Ipadeola, Arinola, Nwafor, Chibuike E

“…Hypertension is a disease characterized by end-organ complications, leading to high morbidity and mortality in many cases. People with untreated or…”
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Characterisation of left ventricular function by tissue Doppler imaging technique in newly diagnosed, untreated hypertensive subjects by Adebayo, Adedeji K, Oladapo, Olulola O, Adebiyi, Adewole A, Ogunleye, Olayinka O, Ogah, Okechukwu S, Ojji, Dike B, Adeoye, Moshood A, Ochulor, Kenneth C, Enakpene, Evbu O, Falase, Ayodele O

“…Hypertension results in structural and functional changes in the heart. Early detection of abnormalities of cardiac structure and function is important in the…”
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Left ventricular geometric patterns in normotensive type 2 diabetic patients in Nigeria: an echocardiographic study by Ojji, Dike B, Adebiyi, Adewole A, Oladapo, Olulola O, Adeleye, Jokotade A, Aje, Akinyemi, Ogah, Okechukwu S, Adebayo, Adedeji K, Falase, Ayodele O

“…Left ventricular hypertrophy has been linked with diabetes mellitus and abnormal glucose tolerance in several studies. Most previous studies have been carried…”
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Abstract 4811: Oxygen tension - dependent differences in cancer cell kinome by Adebayo, Adedeji K., Kumar, Brijesh, Davis, Christopher, Angus, Steven P., Nakshatri, Harikrishna

“…Current approaches to preclinical cancer research often fail to consider the impact of ambient oxygen (O2; ~21%) on cancer cells. This is also true for hypoxia…”
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Blood pressure control and left ventricular hypertrophy in hypertensive Nigerians by Salako, Babatunde L, Ogah, Okechukwu S, Adebiyi, Adewole A, Oladapo, Olulola O, Aje, Akinyemi, Adebayo, Adedeji K, Ojji, Dike B, Ipadeola, Arinola, Nwafor, Chibuike E

“…Background : Hypertension is a disease characterized by end-organ complications, leading to high morbidity and mortality in many cases. People with untreated…”
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