Search Results - "Addou, Sarah"

Domain-Based and Family-Specific Sequence Identity Thresholds Increase the Levels of Reliable Protein Function Transfer by Addou, Sarah, Rentzsch, Robert, Lee, David, Orengo, Christine A.

“…Divergence in function of homologous proteins is based on both sequence and structural changes. Overall enzyme function has been reported to diverge earlier…”
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Exploiting protein structure data to explore the evolution of protein function and biological complexity by Marsden, Russell L, Ranea, Juan A.G, Sillero, Antonio, Redfern, Oliver, Yeats, Corin, Maibaum, Michael, Lee, David, Addou, Sarah, Reeves, Gabrielle A, Dallman, Timothy J, Orengo, Christine A

“…We have used robust protocols to assign sequences from completed genomes to domain structures in the CATH database, allowing up to 60% of domain sequences in…”
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The CATH domain structure database: new protocols and classification levels give a more comprehensive resource for exploring evolution by Greene, Lesley H, Lewis, Tony E, Addou, Sarah, Cuff, Alison, Dallman, Tim, Dibley, Mark, Redfern, Oliver, Pearl, Frances, Nambudiry, Rekha, Reid, Adam, Sillitoe, Ian, Yeats, Corin, Thornton, Janet M, Orengo, Christine A

“…We report the latest release (version 3.0) of the CATH protein domain database (http://www.cathdb.info). There has been a 20% increase in the number of…”
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The CATH domain structure database: new protocols and classification levels give a more comprehensive resource for exploring evolution by Greene, Lesley H., Lewis, Tony E., Addou, Sarah, Cuff, Alison, Dallman, Tim, Dibley, Mark, Redfern, Oliver, Pearl, Frances, Nambudiry, Rekha, Reid, Adam, Sillitoe, Ian, Yeats, Corin, Thornton, Janet M., Orengo, Christine A.

“…We report the latest release (version 3.0) of the CATH protein domain database (). There has been a 20% increase in the number of structural domains classified…”
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Head injuries in prehospital and Emergency Department settings: a prospective multicenter cross-sectional study in France by Dubucs, Xavier, Lafon, Thomas, Adam, Romain, Loth, Solene, Tabaka, Flore, Negrello, Florian, Sebbane, Mustapha, Boucher, Valerie, Mercier, Eric, Émond, Marcel, Charpentier, Sandrine, Balen, Frederic

“…Head injuries are the leading cause of trauma in Emergency Departments (EDs). Recent studies have shown epidemiological changes in patients consulting ED for…”
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The CATH Domain Structure Database and related resources Gene3D and DHS provide comprehensive domain family information for genome analysis by Pearl, Frances, Todd, Annabel, Sillitoe, Ian, Dibley, Mark, Redfern, Oliver, Lewis, Tony, Bennett, Christopher, Marsden, Russell, Grant, Alistair, Lee, David, Akpor, Adrian, Maibaum, Michael, Harrison, Andrew, Dallman, Timothy, Reeves, Gabrielle, Diboun, Ilhem, Addou, Sarah, Lise, Stefano, Johnston, Caroline, Sillero, Antonio, Thornton, Janet, Orengo, Christine

“…The CATH database of protein domain structures (http://www.biochem.ucl.ac.uk/bsm/cath/) currently contains 43 229 domains classified into 1467 superfamilies…”
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Gene3D: modelling protein structure, function and evolution by Yeats, Corin, Maibaum, Michael, Marsden, Russell, Dibley, Mark, Lee, David, Addou, Sarah, Orengo, Christine A

“…The Gene3D release 4 database and web portal (http://cathwww.biochem.ucl.ac.uk:8080/Gene3D) provide a combined structural, functional and evolutionary view of…”
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Trimethylaminuria and a human FMO3 mutation database by Hernandez, Diana, Addou, Sarah, Lee, David, Orengo, Christine, Shephard, Elizabeth A., Phillips, Ian R.

“…Trimethylaminuria (TMAuria), or fish‐odor syndrome, is due to defective flavin‐containing monooxygenase 3 (FMO3). In the liver, this protein catalyzes the…”
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Assessing strategies for improved superfamily recognition by Sillitoe, Ian, Dibley, Mark, Bray, James, Addou, Sarah, Orengo, Christine

“…There are more than 200 completed genomes and over 1 million nonredundant sequences in public repositories. Although the structural data are more sparse…”
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Evolutionary and functional analyses of protein structural families to improve the functional annotation of genomes by Addou, Sarah

“…Protein repertoires of organisms from the three kingdoms of life are formed by the duplication, divergence and recombination of ancestral domains. The domains…”
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Trimethylaminuria and a humanFMO3 mutation database by Hernandez, Diana, Addou, Sarah, Lee, David, Orengo, Christine, Shephard, Elizabeth A., Phillips, Ian R.

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