Search Results - "Addicott, Kelvin W."

Mycobacterium tuberculosis induces decelerated bioenergetic metabolism in human macrophages by Cumming, Bridgette M, Addicott, Kelvin W, Adamson, John H, Steyn, Adrie Jc

“…How ( ) rewires macrophage energy metabolism to facilitate survival is poorly characterized. Here, we used extracellular flux analysis to simultaneously…”
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Compromised Metabolic Reprogramming Is an Early Indicator of CD8+ T Cell Dysfunction during Chronic Mycobacterium tuberculosis Infection by Russell, Shannon L., Lamprecht, Dirk A., Mandizvo, Tawanda, Jones, Terrence T., Naidoo, Vanessa, Addicott, Kelvin W., Moodley, Chivonne, Ngcobo, Bongani, Crossman, David K., Wells, Gordon, Steyn, Adrie J.C.

“…The immunometabolic mechanisms underlying suboptimal T cell immunity in tuberculosis remain undefined. Here, we examine how chronic Mycobacterium tuberculosis…”
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Hydrogen sulfide dysregulates the immune response by suppressing central carbon metabolism to promote tuberculosis by Rahman, Md. Aejazur, Cumming, Bridgette M., Addicott, Kelvin W., Pacl, Hayden T., Russell, Shannon L., Nargan, Kievershen, Naidoo, Threnesan, Ramdial, Pratistadevi K., Adamson, John H., Wang, Rui, Steyn, Adrie J. C.

“…The ubiquitous gasotransmitter hydrogen sulfide (H₂S) has been recognized to play a crucial role in human health. Using cystathionine γ-lyase (CSE)-deficient…”
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Erratum for Cumming et al., “Host Bioenergetic Parameters Reveal Cytotoxicity of Antituberculosis Drugs Undetected Using Conventional Viability Assays” by Cumming, Bridgette M, Baig, Zainab, Addicott, Kelvin W, Chen, Dongquan, Steyn, Adrie J. C

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Host Bioenergetic Parameters Reveal Cytotoxicity of Antituberculosis Drugs Undetected Using Conventional Viability Assays by Cumming, Bridgette M, Baig, Zainab, Addicott, Kelvin W, Chen, Dongquan, Steyn, Adrie J. C

“…High attrition rates in tuberculosis (TB) drug development have been largely attributed to safety, which is likely due to the use of endpoint assays measuring…”
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Longitudinal mitochondrial bioenergetic signatures of blood monocytes and lymphocytes improve during treatment of drug-susceptible pulmonary tuberculosis patients Monocyte/lymphocyte bioenergetic signatures post-TB treatment by Cumming, Bridgette M., Addicott, Kelvin W., Maruri, Fernanda, Pillay, Vanessa, Asmal, Rukaya, Moodley, Sashen, Barreto-Durate, Beatriz, Araújo-Pereira, Mariana, Mazibuko, Matilda, Mhlane, Zoey, Mbatha, Nikiwe, Khan, Khadija, Makhari, Senamile, Karim, Farina, Peetluk, Lauren, Pym, Alexander S., Moosa, Mahomed Yunus S., van der Heijden, Yuri F., Sterling, Timothy S., Andrade, Bruno B., Leslie, Alasdair, Steyn, Adrie J. C.

“…The impact of human pulmonary tuberculosis (TB) on the bioenergetic metabolism of circulating immune cells remains elusive, as does the resolution of these…”
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