Search Results - "Addepalli, Pavani"
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Classification and regression tree-based prediction of 6-mercaptopurine-induced leucopenia grades in children with acute lymphoblastic leukemia
Published in Cancer chemotherapy and pharmacology (01-05-2019)“…Purpose The rationale of the current study was to develop 6-mercaptopurine (6-MP)-mediated hematological toxicity prediction model for acute lymphoblastic…”
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Artificial neural network-based pharmacogenomic algorithm for warfarin dose optimization
Published in Pharmacogenomics (01-01-2016)“…To develop more precise pharmacogenomic algorithm for prediction of safe and effective dose of warfarin. An artificial neural network (ANN) algorithm was…”
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Aberrations in one-carbon metabolism induce oxidative DNA damage in sporadic breast cancer
Published in Molecular and cellular biochemistry (01-03-2011)“…The authors investigated the role of dietary micronutrients and eight functional polymorphisms of one-carbon metabolism in modulating oxidative stress in…”
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Development of neuro-fuzzy model to explore gene-nutrient interactions modulating warfarin dose requirement
Published in Pharmacogenomics (01-08-2016)“…To investigate the influence of alterations in vitamin K (K1, K2 and K3) in modulating warfarin dose requirement. Reverse phase HPLC to determine the plasma…”
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Clinical utility of polymorphisms in one-carbon metabolism for breast cancer risk prediction
Published in Journal of medical and allied sciences (31-01-2011)“…This study addresses the issues in translating the laboratory derived data obtained during discovery phase of research to a clinical setting using a breast…”
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Recipient ABCB1, donor and recipient CYP3A5 genotypes influence tacrolimus pharmacokinetics in liver transplant cases
Published in Pharmacological reports (01-06-2019)“…Effective immunosuppression through optimization of trough levels tacrolimus reduces post-transplant mortality rate in liver transplant cases. Meta-analysis…”
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Epistatic interactions between loci of one-carbon metabolism modulate susceptibility to breast cancer
Published in Molecular biology reports (01-11-2011)“…In view of growing body of evidence substantiating the role of aberrations in one-carbon metabolism in the pathophysiology of breast cancer and lack of studies…”
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Methodological issues in the development of a pharmacogenomic algorithm for warfarin dosing: comparison of two regression approaches
Published in Pharmacogenomics (01-06-2014)“…To ascertain whether multiple polynomial regression (MPR) has any advantage over multiple linear regression (MLR) in developing pharmacogenomic algorithms. Two…”
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Association of aberrations in one-carbon metabolism with molecular phenotype and grade of breast cancer
Published in Molecular carcinogenesis (01-10-2012)“…We have earlier demonstrated the role of aberrant one‐carbon metabolism in the etiology of breast cancer. In the current study, we examine the clinical utility…”
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Cross-Talk Between One-Carbon Metabolism and Xenobiotic Metabolism: Implications on Oxidative DNA Damage and Susceptibility to Breast Cancer
Published in Cell biochemistry and biophysics (01-12-2011)“…The aim of this case–control study is to explore the role of aberrations in xenobiotic metabolism in inducing oxidative DNA damage and altering the…”
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Mechanistic insights into the effect of CYP2C92 and CYP2C93 variants on the 7-hydroxylation of warfarin
Published in Pharmacogenomics (01-03-2015)“…To evaluate the impact of CYP2C9*2 and CYP2C9*3 variants on binding and hydroxylation of warfarin. Multiple linear regression model of warfarin…”
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Retrospective evidence for clinical validity of expanded genetic model in warfarin dose optimization in a South Indian population
Published in Pharmacogenomics (01-06-2012)“…To optimize warfarin dose in patients at risk for thrombotic events, we have recently developed a pharmacogenomic algorithm, which explained 44.9% of the…”
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Mechanistic insights into the effect of
Published in Pharmacogenomics (01-03-2015)“…To evaluate the impact of and variants on binding and hydroxylation of warfarin. Multiple linear regression model of warfarin pharmacokinetics was developed…”
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Modulatory effect of plasma folate and polymorphisms in one-carbon metabolism on catecholamine methyltransferase (COMT) H108L associated oxidative DNA damage and breast cancer risk
Published in Indian journal of biochemistry & biophysics (01-08-2011)“…The present study was aimed to investigate the modulatory role of plasma folate and eight putatively functional polymorphisms of one-carbon metabolism on…”
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O14 Impact of aberrations in xenobiotic metabolism on the susceptibility to systemic lupus erythematosus
Published in Indian journal of rheumatology (2011)Get full text
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