Search Results - "Adatto, Isaac"

Use of Zebrafish in Drug Discovery Toxicology by Cassar, Steven, Adatto, Isaac, Freeman, Jennifer L, Gamse, Joshua T, Iturria, Iñaki, Lawrence, Christian, Muriana, Arantza, Peterson, Randall T, Van Cruchten, Steven, Zon, Leonard I

“…Unpredicted human safety events in clinical trials for new drugs are costly in terms of human health and money. The drug discovery industry attempts to…”
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The effects of intensive feeding on reproductive performance in laboratory zebrafish (Danio rerio) by Adatto, Isaac, Lawrence, Christian, Krug, Lauren, Zon, Leonard I

“…The zebrafish (Danio rerio) is among the most widely used model animals in scientific research. Historically, these fish have been reared in the laboratory…”
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The effects of intensive feeding on reproductive performance in laboratory zebrafish (Danio rerio) by Isaac Adatto, Christian Lawrence, Lauren Krug, Leonard I. Zon

“…The zebrafish (Danio rerio) is among the most widely used model animals in scientific research. Historically, these fish have been reared in the laboratory…”
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RNA helicase DDX21 mediates nucleotide stress responses in neural crest and melanoma cells by Santoriello, Cristina, Sporrij, Audrey, Yang, Song, Flynn, Ryan A., Henriques, Telmo, Dorjsuren, Bilguujin, Custo Greig, Eugenia, McCall, Wyatt, Stanhope, Meredith E., Fazio, Maurizio, Superdock, Michael, Lichtig, Asher, Adatto, Isaac, Abraham, Brian J., Kalocsay, Marian, Jurynec, Michael, Zhou, Yi, Adelman, Karen, Calo, Eliezer, Zon, Leonard I.

“…The availability of nucleotides has a direct impact on transcription. The inhibition of dihydroorotate dehydrogenase (DHODH) with leflunomide impacts…”
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A new system for the rapid collection of large numbers of developmentally staged zebrafish embryos by Adatto, Isaac, Lawrence, Christian, Thompson, Michael, Zon, Leonard I

“…The zebrafish is an excellent genetic and developmental model system used to study biology and disease. While the zebrafish model is associated with high…”
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Transplantation-based screen identifies inducers of muscle progenitor cell engraftment across vertebrate species by Tavakoli, Sahar, Garcia, Vivian, Gähwiler, Eric, Adatto, Isaac, Rangan, Apoorva, Messemer, Kathleen A., Kakhki, Sara Ashrafi, Yang, Song, Chan, Victoria S., Manning, Margot E., Fotowat, Haleh, Zhou, Yi, Wagers, Amy J., Zon, Leonard I.

“…Stem cell transplantation presents a potentially curative strategy for genetic disorders of skeletal muscle, but this approach is limited by the deleterious…”
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Microbial mercury transformations in marine, estuarine and freshwater sediment downstream of the Idrija Mercury Mine, Slovenia by Hines, Mark E., Faganeli, Jadran, Adatto, Isaac, Horvat, Milena

“…The Idrija Mine, the second largest Hg mine in the world, ceased operation in 1995, but still delivers large quantities of Hg downstream including into the…”
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Generation time of zebrafish (Danio rerio) and medakas (Oryzias latipes) housed in the same aquaculture facility by Lawrence, Christian, Adatto, Isaac, Best, Jason, James, Althea, Maloney, Kara

“…The zebrafish and the medaka are both important model organisms in biomedical research. Both species are frequently characterized as having a generation time…”
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Mercury Speciation and Microbial Transformations in Mine Wastes, Stream Sediments, and Surface Waters at the Almadén Mining District, Spain by Gray, John E, Hines, Mark E, Higueras, Pablo L, Adatto, Isaac, Lasorsa, Brenda K

“…Speciation of Hg and conversion to methyl-Hg were evaluated in mine wastes, sediments, and water collected from the Almadén District, Spain, the world's…”
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Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells by Patsch, Christoph, Challet-Meylan, Ludivine, Thoma, Eva C., Urich, Eduard, Heckel, Tobias, O’Sullivan, John F., Grainger, Stephanie J., Kapp, Friedrich G., Sun, Lin, Christensen, Klaus, Xia, Yulei, Florido, Mary H. C., He, Wei, Pan, Wei, Prummer, Michael, Warren, Curtis R., Jakob-Roetne, Roland, Certa, Ulrich, Jagasia, Ravi, Freskgård, Per-Ola, Adatto, Isaac, Kling, Dorothee, Huang, Paul, Zon, Leonard I., Chaikof, Elliot L., Gerszten, Robert E., Graf, Martin, Iacone, Roberto, Cowan, Chad A.

“…The use of human pluripotent stem cells for in vitro disease modelling and clinical applications requires protocols that convert these cells into relevant…”
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Fetal alcohol spectrum disorder predisposes to metabolic abnormalities in adulthood by Weeks, Olivia, Bossé, Gabriel D, Oderberg, Isaac M, Akle, Sebastian, Houvras, Yariv, Wrighton, Paul J, LaBella, Kyle, Iversen, Isabelle, Tavakoli, Sahar, Adatto, Isaac, Schwartz, Arkadi, Kloosterman, Daan, Tsomides, Allison, Charness, Michael E, Peterson, Randall T, Steinhauser, Matthew L, Fazeli, Pouneh K, Goessling, Wolfram

“…Prenatal alcohol exposure (PAE) affects at least 10% of newborns globally and leads to the development of fetal alcohol spectrum disorders (FASDs). Despite its…”
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The Red Light District and Its Effects on Zebrafish Reproduction by Adatto, Isaac, Krug, Lauren, Zon, Leonard Ira

“…Light-dark cycles mimicking natural settings in a zebrafish facility are crucial for maintaining fish with an entrained circadian clock making them an ideal…”
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Cell-specific transcriptional control of mitochondrial metabolism by TIF1γ drives erythropoiesis by Rossmann, Marlies P, Hoi, Karen, Chan, Victoria, Abraham, Brian J, Yang, Song, Mullahoo, James, Papanastasiou, Malvina, Wang, Ying, Elia, Ilaria, Perlin, Julie R, Hagedorn, Elliott J, Hetzel, Sara, Weigert, Raha, Vyas, Sejal, Nag, Partha P, Sullivan, Lucas B, Warren, Curtis R, Dorjsuren, Bilguujin, Greig, Eugenia Custo, Adatto, Isaac, Cowan, Chad A, Schreiber, Stuart L, Young, Richard A, Meissner, Alexander, Haigis, Marcia C, Hekimi, Siegfried, Carr, Steven A, Zon, Leonard I

“…Transcription and metabolism both influence cell function, but dedicated transcriptional control of metabolic pathways that regulate cell fate has rarely been…”
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Telomerase RNA recruits RNA polymerase II to target gene promoters to enhance myelopoiesis by García-Castillo, Jesús, Alcaraz-Pérez, Francisca, Martínez-Balsalobre, Elena, García-Moreno, Diana, Rossmann, Marlies P., Fernández-Lajarín, Miriam, Bernabé-García, Manuel, Pérez-Oliva, Ana B., Rodríguez-Cortez, Virginia C., Bueno, Clara, Adatto, Isaac, Agarwal, Suneet, Menéndez, Pablo, Zon, Leonard I., Mulero, Victoriano, Cayuela, María L.

“…Dyskeratosis congenita (DC) is a rare inherited bone marrow failure and cancer predisposition syndrome caused by mutations in telomerase or telomeric proteins…”
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2021 – TRANSCRIPTIONAL REGULATION OF MITOCHONDRIAL METABOLISM BY TIF1GAMMA DRIVES ERYTHROID PROGENITOR DIFFERENTIATION by Rossmann, Marlies, Hoi, Karen, Chan, Victoria, Abraham, Brian, Yang, Song, Mullahoo, James, Papanastasiou, Malvina, Elia, Ilaria, Vyas, Sejal, Nag, Partha, Sullivan, Lucas, Perlin, Julie, Hagedorn, Elliott, Hetzel, Sara, Weigert, Raha, Warren, Curtis, Dorjsuren, Bilguujin, Greig, Eugenia Custo, Adatto, Isaac, Cowan, Chad, Schreiber, Stuart, Young, Richard, Meissner, Alexander, Haigis, Marcia, Carr, Steven, Zon, Leonard

“…Understanding in-vivo mechanisms of erythropoiesis is critical for directed differentiation approaches to treat blood disorders. Zebrafish moonshine (mon)…”
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A novel method for rearing first-feeding larval zebrafish: polyculture with Type L saltwater rotifers (Brachionus plicatilis) by Best, Jason, Adatto, Isaac, Cockington, Jason, James, Althea, Lawrence, Christian

“…Promoting high rates of growth and survival can be a major challenge in zebrafish culture, especially during the first-feeding stage. Here we describe a new…”
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Mercury methylation in Sphagnum moss mats and its association with sulfate-reducing bacteria in an acidic Adirondack forest lake wetland by Yu, Ri-Qing, Adatto, Isaac, Montesdeoca, Mario R., Driscoll, Charles T., Hines, Mark E., Barkay, Tamar

“…Abstract Processes leading to the bioaccumulation of methylmercury (MeHg) in northern wetlands are largely unknown. We have studied various ecological niches…”
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PPARα Activation Bypasses the Transcription Elongation Defect in Mutant tif1γ Erythroid Differentiation by Rossmann, Marlies P., Bai, Xiaoying, Dorjsuren, Bilguujin, Krug, Lauren, Chiang, Chang-Ying, Lee, Erika, Chaudhry, Wahaj, Kemet, Shakkaura, Adatto, Isaac, Zon, Leonard I.

“…Aberrant erythroid differentiation can give rise to anemias and leukemias. Regulated transcription elongation at erythroid loci is vital for specific…”
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Mercury methylation in Sphagnum moss mats and its association with sulfate-reducing bacteria in an acidic Adirondack forest lake wetland: Mercury methylation in Sphagnum moss mats by Yu, Ri-Qing, Adatto, Isaac, Montesdeoca, Mario R., Driscoll, Charles T., Hines, Mark E., Barkay, Tamar

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Generation time of zebrafish housed in the same aquaculture facility by Lawrence, Christian, Adatto, Isaac, Best, Jason, James, Althea, Maloney, Kara

“…The zebrafish and the medaka are both important model organisms in biomedical research. Both species are frequently characterized as having a generation time…”
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