Search Results - "Adari, Hedy"

VIS832, a novel CD138-targeting monoclonal antibody, potently induces killing of human multiple myeloma and further synergizes with IMiDs or bortezomib in vitro and in vivo by Yu, Tengteng, Chaganty, Bharat, Lin, Liang, Xing, Lijie, Ramakrishnan, Boopathy, Wen, Kenneth, Hsieh, Phillip A., Wollacott, Andrew, Viswanathan, Karthik, Adari, Hedy, Cho, Shih-Feng, Li, Yuyin, Chen, Hailin, Yang, Wenjuan, Xu, Yan, An, Gang, Qiu, Lugui, Munshi, Nikhil, Babcock, Gregory, Shriver, Zachary, Myette, James R., Anderson, Kenneth C., Tai, Yu-Tzu

“…Therapeutically targeting CD138, a define multiple myeloma (MM) antigen, is not yet approved for patients. We here developed and determined the preclinical…”
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Vaccine-Induced Antibodies Inhibit CETP Activity In Vivo and Reduce Aortic Lesions in a Rabbit Model of Atherosclerosis by Rittershaus, Charles W, Miller, David P, Thomas, Lawrence J, Picard, Michele D, Honan, Christopher M, Emmett, Constance D, Pettey, Carolyn L, Adari, Hedy, Hammond, Russell A, Beattie, David T, Callow, Allan D, Marsh, Henry C, Ryan, Una S

“…Using a vaccine approach, we immunized New Zealand White rabbits with a peptide containing a region of cholesteryl ester transfer protein (CETP) known to be…”
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Spontaneous combined hyperlipidemia, coronary heart disease and decreased survival in Dahl salt-sensitive hypertensive rats transgenic for human cholesteryl ester transfer protein by Herrera, Victoria L. M, Makrides, Savvas C, Xie, Hou Xiang, Adari, Hedy, Krauss, Ronald M, Ryan, Una S, Ruiz-Opazo, Nelson

“…The acceleration of atherosclerosis by polygenic (essential) hypertension is well-characterized in humans; however, the lack of an animal model that simulates…”
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Recombinant Glycoproteins That Inhibit Complement Activation and Also Bind the Selectin Adhesion Molecules by Rittershaus, C W, Thomas, L J, Miller, D P, Picard, M D, Geoghegan-Barek, K M, Scesney, S M, Henry, L D, Sen, A C, Bertino, A M, Hannig, G, Adari, H, Mealey, R A, Gosselin, M L, Couto, M, Hayman, E G, Levin, J L, Reinhold, V N, Marsh, Jr, H C

“…Soluble human complement receptor type 1 (sCR1, TP10) has been expressed in Chinese hamster ovary (CHO) DUKX-B11 cells and shown to inhibit the classical and…”
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A Novel CD138-Targeting Monoclonal Antibody Induces Potent Myeloma Killing and Further Synergizes with IMiDs or Bortezomib in in Vitro and In Vivo Preclinical Models of Human Multiple Myeloma by Yu, Tengteng, Chaganty, Bharat, Lin, Liang, Xing, Lijie, Ramakrishnan, Boopathy, Wen, Kenneth, Hsieh, Phillip A, Wollacott, Andrew, Viswanathan, Karthik, Adari, Hedy, Cho, Shih-Feng, Li, Yuyin, Yang, Wenjuan, Chen, Hailin, Xu, Yan, An, Gang, Qiu, Lugui, Munshi, Nikhil C., Babcock, Gregory, Shriver, Zach, Myette, James, Anderson, Kenneth, Tai, Yu-Tzu

“…Immunotherapeutically targeting CD138 has not been successfully translated into substantial clinical benefit in multiple myeloma (MM) patients. We here…”
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An Immune Based, Anti-CD138 Targeting Antibody for the Treatment of Multiple Myeloma by Yu, Tengteng, Xing, Lijie, Lin, Liang, Liu, Jiye, Wen, Kenneth, Cho, Shih-Feng, Hsieh, Phillip, Myette, James, Chaganty, Bharat, Adari, Hedy, Tissire, Hamid, Deotale, Ketan, Shriver, Zach, Munshi, Nikhil, Tai, Yu-Tzu, Anderson, Kenneth

“…CD138 (Syndecan-1), a member of integral membrane family of heparan sulfate proteoglycans (HSPGS), is highly expressed on differentiated plasma cells (PC) and…”
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Guanosine Triphosphatase Activating Protein (GAP) Interacts with the p21 ras Effector Binding Domain by Adari, Hedy, Lowy, Douglas R., Willumsen, Berthe M., Der, Channing J., McCormick, Frank

“…A cytoplasmic protein that greatly enhances the guanosine triphosphatase (GTPase) activity of N-ras protein but does not affect the activity of oncogenic ras…”
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Extended in vivo half-life of human soluble complement receptor type 1 fused to a serum albumin-binding receptor by Makrides, S C, Nygren, P A, Andrews, B, Ford, P J, Evans, K S, Hayman, E G, Adari, H, Uhlén, M, Toth, C A

“…A new approach has been used to extend the T(1/2) of human soluble complement receptor type 1 (sCR1) in rats. The albumin-binding domains B2A3 (BA) and…”
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A tightly regulated high level expression vector that utilizes a thermosensitive lac repressor: production of the human T cell receptor Vβ5.3 in Escherichia coli by Andrews, Beth, Adari, Hedy, Hannig, Gerhard, Lahue, Elaine, Gosselin, Michael, Martin, Sue, Ahmed, Asma, Ford, Pamella J., Hayman, Edward G., Makrides, Savvas C.

“…A series of vectors has been constructed to express the human T cell receptor Vβ5.3 under the control of the hybrid trc promoter in Escherichia coli…”
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Bacteriophage T4 regA protein binds to the Shine-Dalgarno region of gene 44 mRNA by Webster, K R, Adari, H Y, Spicer, E K

“…We have overproduced and purified wild type regA protein, a translational repressor encoded by bacteriophage T4. The repressor activity of the cloned regA…”
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Guanosine triphosphatase activating protein, GAP, interacts with the p21 ras effector binding domain by Adari, Hedy, Lowy, Douglas R, Willumsen, Berthe M, Der, Channing J, McCormick, Frank

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Translational repression in vitro by the bacteriophage T4 regA protein by Adari, H Y, Spicer, E K

“…The bacteriophage T4 translational repressor regA protein has been purified from an overproducing strain, and its activity has been studied in simple in vitro…”
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The genes for galactokinase and uridine monophosphatase-2 are syntenic in the dog (Canis familiaris) by Wilson, D, Adari, H

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Cloning of T4 Gene 32 and Expression of the Wild-Type Protein under λ Promoter PL Regulation in Escherichia coli by Shamoo, Yousif, Adari, Hedy, Konigsberg, William H., Williams, Kenneth R., Chase, John W.

“…Bacteriophage T4 gene 32 encodes a single-stranded DNA binding protein required for T4 DNA replication, recombination, and repair. Previous attempts at cloning…”
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Cloning, Nucleotide Sequence, and Overexpression of the Bacteriophage T4 regA Gene by Adari, Hedy Y., Rose, Karen, Williams, Kenneth R., Konigsberg, William H., Lin, Tsung-Chung, Spicer, Eleanor K.

“…The bacteriophage T4 regA gene codes for a regulatory protein that controls the expression of a number of T4 early genes, apparently at the level of…”
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