Search Results - "Adani, Rellie"
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Enhanced stereoselective hydrolysis of toxic organophosphates by directly evolved variants of mammalian serum paraoxonase
Published in The FEBS journal (01-05-2006)“…We addressed the ability of various organophosphorus (OP) hydrolases to catalytically scavenge toxic OP nerve agents. Mammalian paraoxonase (PON1) was found to…”
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Journal Article -
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The anti-inflammatory and cholinesterase inhibitor bifunctional compound IBU-PO protects from β-amyloid neurotoxicity by acting on Wnt signaling components
Published in Neurobiology of disease (01-02-2005)“…Changes in signal transduction are implicated in neuronal responses to the Alzheimer's amyloid-β-peptide (Aβ), which include neurotransmitter systems and…”
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Journal Article -
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Asymmetric fluorogenic organophosphates for the development of active organophosphate hydrolases with reversed stereoselectivity
Published in Toxicology (Amsterdam) (20-04-2007)“…Abstract In order to enhance the enzymatic detoxification rate of organophosphorus (OP) nerve agents we have searched for more active variants of recombinant…”
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Journal Article Conference Proceeding -
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Bifunctional compounds eliciting both anti-inflammatory and cholinergic activity as potential drugs for neuroinflammatory impairments
Published in Neuroscience letters (07-03-2005)“…We tested two novel bifunctional compounds: ibuprofen- N-octyl-pyridostigmine bromide (IBU-PO) and ibuprofen- N-decyl-pyridostigmine bromide (IBU-PD). They…”
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Journal Article