Search Results - "Adamson, Hope"

Retuning the Catalytic Bias and Overpotential of a [NiFe]-Hydrogenase via a Single Amino Acid Exchange at the Electron Entry/Exit Site by Adamson, Hope, Robinson, Martin, Wright, John J, Flanagan, Lindsey A, Walton, Julia, Elton, Darrell, Gavaghan, David J, Bond, Alan M, Roessler, Maxie M, Parkin, Alison

“…The redox chemistry of the electron entry/exit site in Escherichia coli hydrogenase-1 is shown to play a vital role in tuning biocatalysis. Inspired by nature,…”
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Electrochemical evidence that pyranopterin redox chemistry controls the catalysis of YedY, a mononuclear Mo enzyme by Adamson, Hope, Simonov, Alexandr N., Kierzek, Michelina, Rothery, Richard A., Weiner, Joel H., Bond, Alan M., Parkin, Alison

“…A long-standing contradiction in the field of mononuclear Mo enzyme research is that small-molecule chemistry on active-site mimic compounds predicts ligand…”
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Affimers as anti-idiotypic affinity reagents for pharmacokinetic analysis of biotherapeutics by Adamson, Hope, Nicholl, Amanda, Tiede, Christian, Tang, Anna A, Davidson, Alex, Curd, Helen, Wignall, Alex, Ford, Robert, Nuttall, James, McPherson, Michael J, Johnson, Matt, Tomlinson, Darren C

“…Therapeutic antibodies are the fastest growing class of drugs in the treatment of cancer, and autoimmune and inflammatory diseases that require the concomitant…”
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Affimer reagents as tools in diagnosing plant virus diseases by Hesketh, Emma L., Tiede, Christian, Adamson, Hope, Adams, Thomas L., Byrne, Matthew J., Meshcheriakova, Yulia, Kruse, Inga, McPherson, Michael J., Lomonossoff, George P., Tomlinson, Darren C., Ranson, Neil A.

“…Plant viruses can cause devastating losses to agriculture and are therefore a major threat to food security. The rapid identification of virally-infected crops…”
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Affimer–Enzyme–Inhibitor Switch Sensor for Rapid Wash-free Assays of Multimeric Proteins by Adamson, Hope, Ajayi, Modupe O, Campbell, Emma, Brachi, Erika, Tiede, Christian, Tang, Anna A, Adams, Thomas L, Ford, Robert, Davidson, Alex, Johnson, Matt, McPherson, Michael J, Tomlinson, Darren C, Jeuken, Lars J. C

“…Robust technology is required to underpin rapid point-of-care and in-field diagnostics to improve timely decision making across broad sectors. An attractive…”
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Rapid Quantification of C. difficile Glutamate Dehydrogenase and Toxin B (TcdB) with a NanoBiT Split-Luciferase Assay by Adamson, Hope, Ajayi, Modupe O., Gilroy, Kate E., McPherson, Michael J., Tomlinson, Darren C., Jeuken, Lars J. C.

“…C. difficile infection (CDI) is a leading healthcare-associated infection with a high morbidity and mortality and is a financial burden. No current standalone…”
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Enzyme - Switch sensors for therapeutic drug monitoring of immunotherapies by Campbell, Emma, Adamson, Hope, Kohl, Declan, Tiede, Christian, Wälti, Christoph, Tomlinson, Darren C., Jeuken, Lars J.C.

“…Therapeutic monoclonal antibodies (TmAb) have emerged as effective treatments for a number of cancers and autoimmune diseases. However, large interpatient…”
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Engineering Protein Switches for Rapid Diagnostic Tests by Adamson, Hope, Jeuken, Lars J. C

“…Biological signaling pathways are underpinned by protein switches that sense and respond to molecular inputs. Inspired by nature, engineered protein switches…”
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Principles of Sustained Enzymatic Hydrogen Oxidation in the Presence of Oxygen – The Crucial Influence of High Potential Fe–S Clusters in the Electron Relay of [NiFe]-Hydrogenases by Evans, Rhiannon M, Parkin, Alison, Roessler, Maxie M, Murphy, Bonnie J, Adamson, Hope, Lukey, Michael J, Sargent, Frank, Volbeda, Anne, Fontecilla-Camps, Juan C, Armstrong, Fraser A

“…“Hyd-1”, produced by Escherichia coli, exemplifies a special class of [NiFe]-hydrogenase that can sustain high catalytic H2 oxidation activity in the presence…”
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Analysis of HypD Disulfide Redox Chemistry via Optimization of Fourier Transformed ac Voltammetric Data by Adamson, Hope, Robinson, Martin, Bond, Paul S, Soboh, Basem, Gillow, Kathryn, Simonov, Alexandr N, Elton, Darrell M, Bond, Alan M, Sawers, R. Gary, Gavaghan, David J, Parkin, Alison

“…Rapid disulfide bond formation and cleavage is an essential mechanism of life. Using large amplitude Fourier transformed alternating current voltammetry…”
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Therapeutic drug monitoring of immunotherapies with novel Affimer-NanoBiT sensor construct by Campbell, Emma, Adamson, Hope, Luxton, Timothy, Tiede, Christian, Wälti, Christoph, Tomlinson, Darren C, Jeuken, Lars J. C

“…Concentration-therapeutic efficacy relationships have been observed for several therapeutic monoclonal antibodies (TmAb), where low circulating levels can…”
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Probing biological redox chemistry with fourier transformed ac voltammetry by Adamson, Hope

“…Biological electron transfer is fundamental to life on earth. Photosynthesis, respiration and many other biological processes are underpinned by electron…”
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