Search Results - "Adamson, Eileen"

Vinculin Modulation of Paxillin-FAK Interactions Regulates ERK to Control Survival and Motility by Subauste, M. Cecilia, Pertz, Olivier, Adamson, Eileen D., Turner, Christopher E., Junger, Sachiko, Hahn, Klaus M.

“…Cells lacking vinculin are highly metastatic and motile. The reasons for this finding have remained unclear. Both enhanced survival and motility are critical…”
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Role of vinculin in regulating focal adhesion turnover by Saunders, Ruth M., Holt, Mark R., Jennings, Lisa, Sutton, Deborah H., Barsukov, Igor L., Bobkov, Andrey, Liddington, Robert C., Adamson, Eileen A., Dunn, Graham A., Critchley, David R.

“…Although vinculin (−/−) mouse embryo fibroblasts assemble focal adhesions (FAs), they spread more slowly, less extensively, and close a wound more rapidly than…”
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Identification of Promoters Bound by c-Jun/ATF2 during Rapid Large-Scale Gene Activation following Genotoxic Stress by Hayakawa, Jun, Mittal, Shalu, Wang, Yipeng, Korkmaz, Kemal S., Adamson, Eileen, English, Christopher, Omichi, Masahide, McClelland, Michael, Mercola, Dan

“…The NH2-terminal Jun kinases (JNKs) function in diverse roles through phosphorylation and activation of AP-1 components including ATF2 and c-Jun. However, the…”
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Coactivating Factors p300 and CBP Are Transcriptionally Crossregulated by Egr1 in Prostate Cells, Leading to Divergent Responses by Yu, Jianxiu, de Belle, Ian, Liang, Hongyan, Adamson, Eileen D.

“…Related coactivators p300 and CBP affect the transcriptional activities of many transcription factors (TF), producing multiple downstream effects. Here we show…”
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The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling by de Belle, Ian, Virolle, Thierry, Adamson, Eileen D, Baron, Veronique, Birle, Diana, Mercola, Dan, Mustelin, Tomas

“…The PTEN tumour suppressor and pro-apoptotic gene is frequently mutated in human cancers. We show that PTEN transcription is upregulated by Egr-1 after…”
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Nodal-Dependent Cripto Signaling Promotes Cardiomyogenesis and Redirects the Neural Fate of Embryonic Stem Cells by Parisi, Silvia, D'Andrea, Daniela, Lago, Carmine T., Adamson, Eileen D., Persico, M. Graziella, Minchiotti, Gabriella

“…The molecular mechanisms controlling inductive events leading to the specification and terminal differentiation of cardiomyocytes are still largely unknown. We…”
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Vinculin Controls PTEN Protein Level by Maintaining the Interaction of the Adherens Junction Protein β-Catenin with the Scaffolding Protein MAGI-2 by Subauste, M. Cecilia, Nalbant, Perihan, Adamson, Eileen D., Hahn, Klaus M.

“…PTEN is a frequently mutated tumor suppressor in malignancies. Interestingly, some malignancies exhibit undetectable PTEN protein without mutations or loss of…”
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Early growth response 1 acts as a tumor suppressor in vivo and in vitro via regulation of p53 by KRONES-HERZIG, Anja, MITTAL, Shalu, YULE, Kelly, HONGYAN LIANG, ENGLISH, Chris, URCIS, Rafael, SONI, Tarun, ADAMSON, Eileen D, MERCOLA, Dan

“…The early growth response 1 (Egr1) gene is a transcription factor that acts as both a tumor suppressor and a tumor promoter. Egr1-null mouse embryo fibroblasts…”
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Egr1 promotes growth and survival of prostate cancer cells. Identification of novel Egr1 target genes by Virolle, Thierry, Krones-Herzig, Anja, Baron, Veronique, De Gregorio, Giorgia, Adamson, Eileen D, Mercola, Dan

“…In the majority of aggressive tumorigenic prostate cancer cells, the transcription factor Egr1 is overexpressed. We provide new insights of Egr1 involvement in…”
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Early Growth Response 1 Protein, an Upstream Gatekeeper of the p53 Tumor Suppressor, Controls Replicative Senescence by Krones-Herzig, Anja, Adamson, Eileen, Mercola, Dan

“…The proliferation of most primary cells in culture is limited by replicative senescence and crisis, p53-dependent events. However, the regulation of p53 itself…”
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Egr1 transcription factor: multiple roles in prostate tumor cell growth and survival by Adamson, Eileen D, Mercola, Dan

“…The transcription factor, Egr1, so-called because it is encoded by the immediate early growth response gene, Egr1, is rapidly induced by growth factors to…”
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The Transcription Factor EGR-1 Directly Transactivates the Fibronectin Gene and Enhances Attachment of Human Glioblastoma Cell Line U251 by Liu, Chaoting, Yao, Jin, Mercola, Dan, Adamson, Eileen

“…EGR-1, a transcription factor with important functions in the regulation of growth and differentiation, is highly expressed in brain. Previous studies have…”
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Heterozygous Inactivation of the Vinculin Gene Predisposes to Stress-Induced Cardiomyopathy by Zemljic-Harpf, Alice E., Ponrartana, Sornya, Avalos, Roy T., Jordan, Maria C., Roos, Kenneth P., Dalton, Nancy D., Phan, Vinh Q., Adamson, Eileen D., Ross, Robert S.

“…Vinculin and its muscle splice variant metavinculin link focal adhesions and cell-to-cell contact sites to the actin cytoskeleton. We hypothesized that normal…”
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Survey of Differentially Methylated Promoters in Prostate Cancer Cell Lines by Wang, Yipeng, Yu, Qiuju, Cho, Ann H., Rondeau, Gaelle, Welsh, John, Adamson, Eileen, Mercola, Dan, McClelland, Michael

“…DNA methylation, copy number in the genomes of three immortalized prostate epithelial, five cancer cell lines (LNCaP, PC3, PC3M, PC3M-Pro4, PC3MLN4) were…”
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Egr1 regulates the coordinated expression of numerous EGF receptor target genes as identified by ChIP-on-chip by Arora, Shilpi, Wang, Yipeng, Jia, Zhenyu, Vardar-Sengul, Saynur, Munawar, Ayla, Doctor, Kutbuddin S, Birrer, Michael, McClelland, Michael, Adamson, Eileen, Mercola, Dan

“…UV irradiation activates the epidermal growth factor receptor, induces Egr1 expression and promotes apoptosis in a variety of cell types. We examined the…”
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Insulin-like Growth Factor-II Regulates PTEN Expression in the Mammary Gland by Moorehead, Roger A., Hojilla, Carlo V., De Belle, Ian, Wood, Geoffrey A., Fata, Jimmie E., Adamson, Eileen D., Watson, Katrina L.M., Edwards, Dylan R., Khokha, Rama

“…The tumor suppressor PTEN is altered in many cancers, including breast cancer, but only a handful of factors are known to control its expression. PTEN plays a…”
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Cripto: A tumor growth factor and more by Adamson, Eileen D., Minchiotti, Gabriella, Salomon, David S.

“…Cripto, a growth factor with an EGF‐like domain, and the first member of the EGF‐CFC family of genes to be sequenced and characterized, contributes to…”
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Cross-regulation between Egr-1 and APE/Ref-1 during early response to oxidative stress in the human osteoblastic HOBIT cell line: evidence for an autoregulatory loop by Pines, Alex, Bivi, Nicoletta, Romanello, Milena, Damante, Giuseppe, Kelley, Mark R, Adamson, Eileen D, D'Andrea, Paola, Quadrifoglio, Franco, Moro, Luigi, Tell, Gianluca

“…The Early Growth Response protein (Egr-1) is a C(2)H(2)-zinc finger-containing transcriptional regulator involved in the control of cell proliferation and…”
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UV Activates Growth Factor Receptors via Reactive Oxygen Intermediates by Huang, Ruo-Pan, Wu, Jie-Xin, Fan, Yan, Adamson, Eileen D.

“…Exposure of mammalian cells to UV irradiation induces rapid and transient expression of early growth response-1 gene (Egr-1) encoding a transcription factor…”
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The Transcription Factor EGR-1 Suppresses Transformation of Human Fibrosarcoma HT1080 Cells by Coordinated Induction of Transforming Growth Factor-β1, Fibronectin, and Plasminogen Activator Inhibitor-1 by Liu, Chaoting, Yao, Jin, de Belle, Ian, Huang, Ruo-Pan, Adamson, Eileen, Mercola, Dan

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