Search Results - "Adams, Wade J."

Preclinical and clinical evidence for the collaborative transport and renal secretion of an oxazolidinone antibiotic by organic anion transporter 3 (OAT3/SLC22A8) and multidrug and toxin extrusion protein 1 (MATE1/SLC47A1) by Lai, Yurong, Sampson, Kathleen E, Balogh, Larissa M, Brayman, Timothy G, Cox, Steven R, Adams, Wade J, Kumar, Vikas, Stevens, Jeffrey C

“…N-({(5S)-3-[4-(1,1-dioxidothiomorpholin-4-yl)-3,5-difluorophenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)acetamide (PNU-288034), an oxazolidinone antibiotic, was…”
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PPARγ-sparing thiazolidinediones as insulin sensitizers. Design, synthesis and selection of compounds for clinical development by Tanis, Steven P., Colca, Jerry R., Parker, Timothy T., Artman, Gerald D., Larsen, Scott D., McDonald, William G., Gadwood, Robert C., Kletzien, Rolf F., Zeller, James B., Lee, Pil H., Adams, Wade J.

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Physiology and pharmacokinetics of a novel hemoglobin-based oxygen carrier in humans by Hughes, Jr, Antal, Edward J, Locker, Paula K, Francom, Steven F, Adams, Wade J, Jacobs, Jr

“…OBJECTIVE To evaluate the physiology and pharmacokinetics of a novel hemoglobin-based oxygen carrier of bovine origin. DESIGN Randomized, single-blind,…”
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Identification of Phenylisoxazolines as Novel and Viable Antibacterial Agents Active against Gram-Positive Pathogens by Barbachyn, Michael R, Cleek, Gary J, Dolak, Lester A, Garmon, Stuart A, Morris, Joel, Seest, Eric P, Thomas, Richard C, Toops, Dana S, Watt, William, Wishka, Donn G, Ford, Charles W, Zurenko, Gary E, Hamel, Judith C, Schaadt, Ronda D, Stapert, Douglas, Yagi, Betty H, Adams, Wade J, Friis, Janice M, Slatter, J. Gregory, Sams, James P, Oien, Nancee L, Zaya, Matthew J, Wienkers, Larry C, Wynalda, Michael A

“…A new and promising group of antibacterial agents, collectively known as the oxazolidinones and exemplified by linezolid (PNU-100766, marketed as Zyvox), have…”
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Antibacterial Oxazolidinones Possessing a Novel C-5 Side Chain. (5R)-trans-3-[3-Fluoro-4- (1-oxotetrahydrothiopyran-4-yl)phenyl]-2- oxooxazolidine-5-carboxylic Acid Amide (PF-00422602), a New Lead Compound by Poel, Toni-Jo, Thomas, Richard C, Adams, Wade J, Aristoff, Paul A, Barbachyn, Michael R, Boyer, Frederick E, Brieland, Joan, Brideau, Roger, Brodfuehrer, Joanne, Brown, Alan P, Choy, Allison L, Dermyer, Michael, Dority, Michael, Ford, Charles W, Gadwood, Robert C, Hanna, Debra, Hongliang, Cai, Huband, Michael D, Huber, Christopher, Kelly, Rose, Kim, Ji-Young, Martin, Joseph P, Pagano, Paul J, Ross, Daniel, Skerlos, Laura, Sulavik, Mark C, Zhu, Tong, Zurenko, Gary E, Prasad, J. V. N. Vara

“…Oxazolidinones possessing a C-5 carboxamide functionality (reverse amides) represent a new series of compounds that block bacterial protein synthesis. These…”
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Predicting oral absorption of drugs: A case study with a novel class of antimicrobial agents by HILGERS, Allen R, SMITH, Donald P, SHONE, Eric M, BURTON, Philip S, BIERMACHER, John J, DAY, Jeffrey S, JENSEN, Jana L, SIMS, Sandra M, ADAMS, Wade J, FRIIS, Janice M, PALANDRA, Joe, HOSLEY, John D

“…The purpose of this work was to evaluate an oral absorption prediction model, maximum absorbable dose (MAD), which predicts a theoretical dose of drug that…”
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New Antibacterial tetrahydro-4(2 H)-thiopyran and thiomorpholine S-oxide and S, S-dioxide phenyloxazolidinones by Singh, Upinder, Raju, B, Lam, Stuart, Zhou, Joseph, Gadwood, Robert C, Ford, Charles W, Zurenko, Gary E, Schaadt, Ronda D, Morin, Sara E, Adams, Wade J, Friis, Janice M, Courtney, Maria, Palandra, Joe, Hackbarth, Corinne J, Lopez, Sara, Wu, Charlotte, Mortell, Kathleen H, Trias, Joaquim, Yuan, Zhengyu, Patel, Dinesh V, Gordeev, Mikhail F

“…Combinatorial libraries of N-acylated 5-( S)-aminomethyloxazolidinone derivatives of S-oxide and S, S-dioxide tetrahydro-4(2H)-thiopyranyl and thiomorpholine…”
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The effect of remote chirality on the antibacterial activity of indolinyl, tetrahydroquinolyl and dihydrobenzoxazinyl oxazolidinones by Ciske, Fred L, Barbachyn, Michael R, Genin, Michael J, Grega, Kevin C, Lee, Chi Sing, Dolak, Lester A, Seest, Eric P, Watt, William, Adams, Wade J, Friis, Janice M, Ford, Charles W, Zurenko, Gary E

“…The oxazolidinones are promising agents for the treatment of infections caused by gram-positive bacteria, including multidrug-resistant strains. In ongoing…”
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Targeting Delavirdine/Atevirdine Resistant HIV-1:  Identification of (Alkylamino)piperidine-Containing Bis(heteroaryl)piperazines as Broad Spectrum HIV-1 Reverse Transcriptase Inhibitors by Romero, Donna L, Olmsted, Robert A, Poel, Toni Jo, Morge, Raymond A, Biles, Carolyn, Keiser, Barbara J, Kopta, Laurice A, Friis, Jan M, Hosley, John D, Stefanski, Kevin J, Wishka, Donn G, Evans, David B, Morris, Joel, Stehle, Randy G, Sharma, Satish K, Yagi, Yoshihiko, Voorman, Richard L, Adams, Wade J, Tarpley, W. Gary, Thomas, Richard C

“…A novel class of bis(heteroaryl)piperazine (BHAP) analogs which possesses the ability to inhibit NNRTI (non-nucleoside reverse transcriptase inhibitor)…”
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Nitrogen−Carbon-Linked (Azolylphenyl)oxazolidinones with Potent Antibacterial Activity Against the Fastidious Gram-Negative Organisms Haemophilus influenzae and Moraxella catarrhalis by Genin, Michael J, Hutchinson, Douglas K, Allwine, Debra A, Hester, Jackson B, Emmert, D. Edward, Garmon, Stuart A, Ford, Charles W, Zurenko, Gary E, Hamel, Judith C, Schaadt, Ronda D, Stapert, Douglas, Yagi, Betty H, Friis, Janice M, Shobe, Eric M, Adams, Wade J

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Stereochemistry of the Carbonyl Reduction of MSDC‐0602, An mTOT‐modulating Insulin‐sensitizer for the Treatment of Nonalcoholic Steatohepatitis (NASH) by Adams, Wade J, Yousey, Thad, Bourdon, Kelly, Talay, Susan, Colca, Jerry R

“…Abstract only The objective of this study was to determine the stereochemistry of the carbonyl reduction of MSDC‐0602 in human, monkey and rat plasma using a…”
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Structure, equilibrium conformation, and pseudorotation in cyclopentane. An electron diffraction study by Adams, Wade J, Geise, Herman J, Bartell, Lawrence S

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Synthesis and Bioactivity of Novel Bis(heteroaryl)piperazine (BHAP) Reverse Transcriptase Inhibitors:  Structure−Activity Relationships and Increased Metabolic Stability of Novel Substituted Pyridine Analogs by Genin, Michael J., Poel, Toni J., Yagi, Yoshihiko, Biles, Carolyn, Althaus, Irene, Keiser, Barbara J., Kopta, Laurice A., Friis, Jan M., Reusser, Fritz, Adams, Wade J., Voorman, Richard L., Thomas, Richard C., Romero, Donna L.

“…The major route of metabolism of the bis(heteroaryl)piperazine (BHAP) class of reverse transcriptase inhibitors (RTIs), atevirdine and delavirdine, is via…”
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Synthesis and Structure−Activity Relationships of the (Alkylamino)piperidine-Containing BHAP Class of Non-Nucleoside Reverse Transcriptase Inhibitors:  Effect of 3-Alkylpyridine Ring Substitution by Genin, Michael J, Poel, Toni J, May, Paul D, Kopta, Laurice A, Yagi, Yoshihiko, Olmsted, Robert A, Friis, Janice M, Voorman, Richard L, Adams, Wade J, Thomas, Richard C, Romero, Donna L

“…Development of resistance to currently approved HIV therapies has continued to fuel research efforts to improve the metabolic stability and spectrum of…”
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Excretion mass balance and quantitative whole‐body autoradiography following a single oral (PO) administration of [14C]MSDC 0602, an mTOT‐modulating insulin sensitizer, in Sprague Dawley (SD) and Long‐Evans (LE) rats by Adams, Wade J., Colca, Jerry R., Lordi, Alfred W., Solon, Eric G.

“…Abstract only The objectives of this study were to determine the mass balance excretion, plasma pharmacokinetics and tissue distribution of radioactivity…”
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Pharmacokinetics and systemic bioavailability of menogaril, and anthracycline antitumor agent, in the mouse, dog, and monkey by ADAMS, W. J, MCGOVREN, J. P, DALM, E. A, BREWER, J. E, HOSLEY, J. D

“…Menogaril is an antitumor agent of the anthracycline type which is less cardiotoxic than doxorubicin in a chronic rabbit model and is active in experimental…”
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Liquid chromatographic determination of guanadrel in laboratory animal diet as the fluorescent acetylacetone derivative by Bombardt, Paul A, Adams, Wade J

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Quantitation of anthracycline antitumor agent menogarol in plasma using liquid chromatography with fluorescence detection by McGovren, J. Patrick, Hamilton, Ramon D, Adams, Wade J, Pratt, Evelyn A

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Studies of Abeta pharmacodynamics in the brain, cerebrospinal fluid, and plasma in young (plaque-free) Tg2576 mice using the gamma-secretase inhibitor N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide (LY-411575) by Lanz, Thomas A, Hosley, John D, Adams, Wade J, Merchant, Kalpana M

“…A previous study by us suggests the utility of cerebrospinal fluid (CSF) and plasma Abeta as biomarkers of beta- or gamma-secretase inhibition. The present…”
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The effect of remote chirality on the antibacterial activity of indolinyl, tetrahydroquinolyl and dihydrobenzoxazinyl oxazolidinones: Antibacterial agents: solutions for the evolving problems of resistance by CISKE, Fred L, BARBACHYN, Michael R, FORD, Charles W, ZURENKO, Gary E, GENIN, Michael J, GREGA, Kevin C, CHI SING LEE, DOLAK, Lester A, SEEST, Eric P, WATT, William, ADAMS, Wade J, FRIIS, Janice M

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