Search Results - "Adams, Sean H."

Emerging Perspectives on Essential Amino Acid Metabolism in Obesity and the Insulin-Resistant State by Adams, Sean H.

“…Dysregulation of insulin action is most often considered in the context of impaired glucose homeostasis, with the defining feature of diabetes mellitus being…”
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Acylcarnitines—old actors auditioning for new roles in metabolic physiology by McCoin, Colin S., Knotts, Trina A., Adams, Sean H.

“…Key Points Long-chain acylcarnitines (LCACs) are lipid derivatives generated from carnitine by mitochondrial carnitine O-palmitoyltransferase 1 or through the…”
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High amylose resistant starch diet ameliorates oxidative stress, inflammation, and progression of chronic kidney disease by Vaziri, Nosratola D, Liu, Shu-Man, Lau, Wei Ling, Khazaeli, Mahyar, Nazertehrani, Sohrab, Farzaneh, Seyed H, Kieffer, Dorothy A, Adams, Sean H, Martin, Roy J

“…Inflammation is a major mediator of CKD progression and is partly driven by altered gut microbiome and intestinal barrier disruption, events which are caused…”
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Plasma Metabolomic Profiles Reflective of Glucose Homeostasis in Non-Diabetic and Type 2 Diabetic Obese African-American Women by Fiehn, Oliver, Garvey, W. Timothy, Newman, John W, Lok, Kerry H, Hoppel, Charles L, Adams, Sean H, Gimble, Jeffrey M

“…Insulin resistance progressing to type 2 diabetes mellitus (T2DM) is marked by a broad perturbation of macronutrient intermediary metabolism. Understanding the…”
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Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways[S] by Huang, Shurong, Rutkowsky, Jennifer M., Snodgrass, Ryan G., Ono-Moore, Kikumi D., Schneider, Dina A., Newman, John W., Adams, Sean H., Hwang, Daniel H.

“…Toll-like receptor 4 (TLR4) and TLR2 were shown to be activated by saturated fatty acids (SFAs) but inhibited by docosahexaenoic acid (DHA). However, one…”
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Acylcarnitines activate proinflammatory signaling pathways by Rutkowsky, Jennifer M, Knotts, Trina A, Ono-Moore, Kikumi D, McCoin, Colin S, Huang, Shurong, Schneider, Dina, Singh, Shamsher, Adams, Sean H, Hwang, Daniel H

“…Incomplete β-oxidation of fatty acids in mitochondria is a feature of insulin resistance and type 2 diabetes mellitus (T2DM). Previous studies revealed that…”
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A comparative study of mitochondrial respiration in circulating blood cells and skeletal muscle fibers in women by Rose, Shannon, Carvalho, Eugenia, Diaz, Eva C, Cotter, Matthew, Bennuri, Sirish C, Azhar, Gohar, Frye, Richard E, Adams, Sean H, Børsheim, Elisabet

“…Skeletal muscle mitochondrial respiration is thought to be altered in obesity, insulin resistance, and type 2 diabetes; however, the invasive nature of tissue…”
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Impact of Dietary Fibers on Nutrient Management and Detoxification Organs: Gut, Liver, and Kidneys by Kieffer, Dorothy A, Martin, Roy J, Adams, Sean H

“…Increased dietary fiber (DF) intake elicits a wide range of physiologic effects, not just locally in the gut, but systemically. DFs can greatly alter the gut…”
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Regulation of adipose branched-chain amino acid catabolism enzyme expression and cross-adipose amino acid flux in human obesity by Lackey, Denise E, Lynch, Christopher J, Olson, Kristine C, Mostaedi, Rouzbeh, Ali, Mohamed, Smith, William H, Karpe, Fredrik, Humphreys, Sandy, Bedinger, Daniel H, Dunn, Tamara N, Thomas, Anthony P, Oort, Pieter J, Kieffer, Dorothy A, Amin, Rajesh, Bettaieb, Ahmed, Haj, Fawaz G, Permana, Paska, Anthony, Tracy G, Adams, Sean H

“…Elevated blood branched-chain amino acids (BCAA) are often associated with insulin resistance and type 2 diabetes, which might result from a reduced cellular…”
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Myoglobin Interaction with Lactate Rapidly Releases Oxygen: Studies on Binding Thermodynamics, Spectroscopy, and Oxygen Kinetics by Adepu, Kiran Kumar, Bhandari, Dipendra, Anishkin, Andriy, Adams, Sean H, Chintapalli, Sree V

“…Myoglobin (Mb)-mediated oxygen (O ) delivery and dissolved O in the cytosol are two major sources that support oxidative phosphorylation. During intense…”
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Interindividual Variability in Postprandial Plasma Fructose Patterns in Adults by Gladding, Mia, Shen, Xiaotao, Snyder, Michael P, Havel, Peter J, Adams, Sean H

“…High fructose consumption is associated with an increased risk of cardiometabolic disease, and fructose feeding dose-dependently induces markers reflective of…”
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Type 2 Diabetes Associated Changes in the Plasma Non-Esterified Fatty Acids, Oxylipins and Endocannabinoids by Grapov, Dmitry, Adams, Sean H, Pedersen, Theresa L, Garvey, W. Timothy, Newman, John W, Schunck, Wolf-Hagen

“…Type 2 diabetes has profound effects on metabolism that can be detected in plasma. While increases in circulating non-esterified fatty acids (NEFA) are…”
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Myoglobin–Pyruvate Interactions: Binding Thermodynamics, Structure–Function Relationships, and Impact on Oxygen Release Kinetics by Adepu, Kiran Kumar, Bhandari, Dipendra, Anishkin, Andriy, Adams, Sean H., Chintapalli, Sree V.

“…Myoglobin (Mb), besides its roles as an oxygen (O2) carrier/storage protein and nitric oxide NO scavenger/producer, may participate in lipid trafficking and…”
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Novel odd-chain cyclopropane fatty acids: detection in a mammalian lipidome and uptake by hepatosplanchnic tissues by Sobhi, Hany F., Mercer, Kelly E., Lan, Renny S., Yeruva, Laxmi, Ten Have, Gabriella A.M., Deutz, Nicolaas E.P., Piccolo, Brian D., Debédat, Jean, Pack, Lindsay M., Adams, Sean H.

“…Microbe-produced molecules (xenometabolites) found in foods or produced by gut microbiota are increasingly implicated in microbe-microbe and microbe-host…”
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Is palmitate truly proinflammatory? Experimental confounders and context-specificity by Ono-Moore, Kikumi D, Blackburn, Michael L, Adams, Sean H

“…Based primarily on cell culture results, saturated fatty acids (SFAs) are proposed to promote inflammation and contribute to metabolic dysfunction through…”
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Contributions of adipose tissue architectural and tensile properties toward defining healthy and unhealthy obesity by Lackey, Denise E, Burk, David H, Ali, Mohamed R, Mostaedi, Rouzbeh, Smith, William H, Park, Jiyoung, Scherer, Philipp E, Seay, Shundra A, McCoin, Colin S, Bonaldo, Paolo, Adams, Sean H

“…The extracellular matrix (ECM) plays an important role in the maintenance of white adipose tissue (WAT) architecture and function, and proper ECM remodeling is…”
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Metaproteomics reveals potential mechanisms by which dietary resistant starch supplementation attenuates chronic kidney disease progression in rats by Zybailov, Boris L, Glazko, Galina V, Rahmatallah, Yasir, Andreyev, Dmitri S, McElroy, Taylor, Karaduta, Oleg, Byrum, Stephanie D, Orr, Lisa, Tackett, Alan J, Mackintosh, Samuel G, Edmondson, Ricky D, Kieffer, Dorothy A, Martin, R J, Adams, Sean H, Vaziri, Nosratola D, Arthur, John M

“…Resistant starch is a prebiotic metabolized by the gut bacteria. It has been shown to attenuate chronic kidney disease (CKD) progression in rats. Previous…”
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Leucine and Protein Metabolism in Obese Zucker Rats by She, Pengxiang, Olson, Kristine C, Kadota, Yoshihiro, Inukai, Ayami, Shimomura, Yoshiharu, Hoppel, Charles L, Adams, Sean H, Kawamata, Yasuko, Matsumoto, Hideki, Sakai, Ryosei, Lang, Charles H, Lynch, Christopher J, Blachier, François

“…Branched-chain amino acids (BCAAs) are circulating nutrient signals for protein accretion, however, they increase in obesity and elevations appear to be…”
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Computational Analysis Reveals Unique Binding Patterns of Oxygenated and Deoxygenated Myoglobin to the Outer Mitochondrial Membrane by Anishkin, Andriy, Adepu, Kiran Kumar, Bhandari, Dipendra, Adams, Sean H, Chintapalli, Sree V

“…Myoglobin (Mb) interaction with the outer mitochondrial membrane (OMM) promotes oxygen (O ) release. However, comprehensive molecular details on specific…”
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Fibroblast Growth Factor 19 Increases Metabolic Rate and Reverses Dietary and Leptin-Deficient Diabetes by Fu, Ling, John, Linu M, Adams, Sean H, Yu, Xing Xian, Tomlinson, Elizabeth, Renz, Mark, Williams, P. Mickey, Soriano, Robert, Corpuz, Racquel, Moffat, Barbara, Vandlen, Richard, Simmons, Laura, Foster, Jessica, Stephan, Jean-Philippe, Tsai, Siao Ping, Stewart, Timothy A

“…Hormonal control of metabolic rate can be important in regulating the imbalance between energy intake and expenditure that underlies the development of…”
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