Search Results - "Adams, Sally E."

Targeting gp100 and TRP-2 with a DNA vaccine: Incorporating T cell epitopes with a human IgG1 antibody induces potent T cell responses that are associated with favourable clinical outcome in a phase I/II trial by Patel, Poulam M., Ottensmeier, Christian H., Mulatero, Clive, Lorigan, Paul, Plummer, Ruth, Pandha, Hardev, Elsheikh, Somaia, Hadjimichael, Efthymios, Villasanti, Naty, Adams, Sally E., Cunnell, Michelle, Metheringham, Rachael L., Brentville, Victoria A., Machado, Lee, Daniels, Ian, Gijon, Mohamed, Hannaman, Drew, Durrant, Lindy G.

“…A DNA vaccine, SCIB1, incorporating two CD8 and two CD4 epitopes from TRP-2/gp100 was evaluated in patients with metastatic melanoma. Each patient received…”
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An evaluation of adverse incident reporting by Stanhope, Nicola, Crowley-Murphy, Margaret, Vincent, Charles, O'Connor, Anne M, Taylor-Adams, Sally E.

“…: To examine the reliability of adverse incident‐reporting systems we carried out a retrospective review of the mother and baby case notes from a series of 250…”
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Applying human factors methods to clinical risk management in obstetrics by Stanhope, Nicola, Vincent, Charles, Taylor‐Adams, Sally E., O'Connor, Anne M., Beard, R. W.

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The expression of hybrid HIV:Ty virus-like particles in yeast by Adams, Sally E, Dawson, Keith M, Gull, Keith, Kingsman, Susan M, Kingsman, Alan J

“…The yeast retrotransposon, Ty, encodes a set of proteins that are assembled into virus-like particles, Ty-VLPs (refs 1, 2). These proteins include Ty-VLP…”
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The functions and relationships of Ty-VLP proteins in yeast reflect those of mammalian retroviral proteins by Adams, S E, Mellor, J, Gull, K, Sim, R B, Tuite, M F, Kingsman, S M, Kingsman, A J

“…We have identified the major structural core proteins of Ty virus-like particles (Ty-VLPs) and shown that they are generated by proteolytic cleavage of the…”
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HIV expression strategies: ribosomal frameshifting is directed by a short sequence in both mammalian and yeast systems by Wilson, W, Braddock, M, Adams, S E, Rathjen, P D, Kingsman, S M, Kingsman, A J

“…The pol gene of the human immunodeficiency virus (HIV-1) is expressed as a gag:pol fusion, arising from a ribosomal frameshift that brings the overlapping,…”
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Targeted lymph node immunization with simian immunodeficiency virus p27 antigen to elicit genital, rectal, and urinary immune responses in nonhuman primates by Lehner, T, Bergmeier, LA, Tao, L, Panagiotidi, C, Klavinskis, LS, Hussain, L, Ward, RG, Meyers, N, Adams, SE, Gearing, AJ

“…A s.c. route of immunization was developed in non-human primates, which targets the genitourinary-rectal associated lymphoid tissue. A vaccine consisting of…”
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Induction of HIV-specific cytotoxic T lymphocytes in vivo with hybrid HIV-1 V3:Ty-virus-like particles by Layton, GT, Harris, SJ, Gearing, AJ, Hill-Perkins, M, Cole, JS, Griffiths, JC, Burns, NR, Kingsman, AJ, Adams, SE

“…In general, it has proven difficult to induce CTL responses using simple proteins or peptides without resorting to specialized adjuvants. In this study we show…”
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HIV-1 TAT "activates" presynthesized RNA in the nucleus by Braddock, M, Chambers, A, Wilson, W, Esnouf, M P, Adams, S E, Kingsman, A J, Kingsman, S M

“…Replication of the human immunodeficiency virus (HIV-1) depends upon the viral TAT protein. TAT stimulates gene expression via a target response sequence (TAR)…”
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Hybrid human immunodeficiency virus Gag particles as an antigen carrier system: induction of cytotoxic T-cell and humoral responses by a Gag:V3 fusion by GRIFFITHS, J. C, HARRIS, S. J, LAYTON, G. T, BERRIE, E. L, FRENCH, T. J, BURNS, N. R, ADAMS, S. E, KINGSMAN, A. J

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An Immunological Analysis of Ty1 Virus-like Particle Structure by Brookman, Jayne L., Stott, Andrew J., Cheeseman, Philip J., Burns, Nigel R., Adams, Sally E., Kingsman, Alan J., Gull, K.

“…We present an immunological characterization of the Ty1 virus-like particle (VLP). A panel of monoclonal and polyclonal antibodies were raised against the TYA…”
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T- and B-Cell Functions and Epitope Expression in Nonhuman Primates Immunized with Simian Immunodeficiency Virus Antigen by the Rectal Route by Lehner, Thomas, Brookes, Roger, Panagiotidi, Christina, Tao, Louisa, Klavinskis, Linda S., Walker, Julia, Walker, Paul, Ward, Robert, Hussain, Luma, Andy J. H. Gearing, Adams, Sally E., Bergmeier, Lesley A.

“…Transmission of human immunodeficiency virus (HIV) in North America and Europe occurs most commonly through the rectal mucosa during homosexual intercourse…”
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Mucosal model of genital immunization in male rhesus macaques with a recombinant simian immunodeficiency virus p27 antigen by LEHNER, T, TAO, L, PANAGIOTIDI, C, KLAVINSKIS, L. S, BROOKES, R, HUSSAIN, L, MEYERS, N, ADAMS, S. E, GEARING, A. J. H, BERGMEIER, L. A

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Yeast retrotransposon particles as antigen delivery systems by Kingsman, A J, Burns, N R, Layton, G T, Adams, S E

“…The development of technologies to produce recombinant proteins for use in the pharmaceutical industry has made substantial advances, in particular in the area…”
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Immunization of human HIV-seronegative volunteers with recombinant p17/p24:Ty virus-like particles elicits HIV-1 p24-specific cellular and humoral immune responses by Martin, S J, Vyakarnam, A, Cheingsong-Popov, R, Callow, D, Jones, K L, Senior, J M, Adams, S E, Kingsman, A J, Matear, P, Gotch, F M

“…To evaluate the immune response to HIV-1 p24 generated in vivo by p17/p24:Ty virus-like particles (p17/p24:Ty-VLP) by examining the lymphoproliferative and…”
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Identification of Immunodominant Regions and Linear B Cell Epitopes of the gE Envelope Protein of Varicella-Zoster Virus by FOWLER, WENDY J., GARCIA-VALCARCEL, MERCEDES, HILL-PERKINS, MICHELE S., MURPHY, GARY, HARPER, DAVID R., JEFFRIES, DONALD J., BURNS, NIGEL R., ADAMS, SALLY E., KINGSMAN, ALAN J., LAYTON, GUY T.

“…The envelope proteins of varicella-zoster virus (VZV) are highly immunogenic and one of the most abundant is glycoprotein E (gE). However, its immunodominant…”
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Symmetry, flexibility and permeability in the structure of yeast retrotransposon virus-like particles by Burns, N.R, Saibil, H.R, White, N.S, Pardon, J.F, Timmins, P.A, Richardson, S.M.H, Richards, B.M, Adams, S.E, Kingsman, S.M, Kingsman, A.J

“…The virus-like particles (VLPs) of the yeast retrotransposon Ty are genetically, structurally and functionally analogous to retroviral nucleocapsids or cores…”
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Generation of diversity in the hierarchy of T-cell epitope responses following different routes of immunization with simian immunodeficiency virus protein by Brookes, R, Bergmeier, L A, Mitchell, E, Walker, J, Tao, L, Klavinskis, L, Meyers, N J, Layton, G, Adams, S E, Lehner, T

“…To examine whether the route of immunization determines the hierarchy of T-cell epitope proliferative responses in macaques. Macaques were immunized with a…”
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Use of new vectors for the development of vaccines by Adams, S E, Paoletti, E

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HIV p24-specific helper T cell clones from immunized primates recognize highly conserved regions of HIV-1 by Mills, KH, Kitchin, PA, Mahon, BP, Barnard, AL, Adams, SE, Kingsman, SM, Kingsman, AJ

“…We have investigated Th cell recognition of the HIV core protein p24 by using CD4+ T cell clones derived from cynomolgus macaques immunized with hybrid HIV…”
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