Search Results - "Adams, Robert N."

Clinical comparison of muscle-specific tyrosine kinase (MuSK) antibody-positive and -negative myasthenic patients by Zhou, Lan, McConville, John, Chaudhry, Vinay, Adams, Robert N., Skolasky, Richard L., Vincent, Angela, Drachman, Daniel B.

“…We assayed cryopreserved sera from 38 acetylcholine receptor (AChR) antibody‐negative patients with myasthenia gravis (MG) who were followed clinically for…”
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Strategy for treating motor neuron diseases using a fusion protein of botulinum toxin binding domain and streptavidin for viral vector access: work in progress by Drachman, Daniel B, Adams, Robert N, Balasubramanian, Uma, Lu, Yang

“…Although advances in understanding of the pathogenesis of amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA) have suggested attractive…”
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Rebooting the Immune System with High-Dose Cyclophosphamide for Treatment of Refractory Myasthenia Gravis by Drachman, Daniel B., Adams, Robert N., Hu, Rong, Jones, Richard J., Brodsky, Robert A.

“…A small but important proportion of patients with myasthenia gravis (MG) are refractory to conventional immunotherapy. We have treated 12 such patients by…”
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Functional activities of autoantibodies to acetylcholine receptors and the clinical severity of myasthenia gravis by Drachman, D B, Adams, R N, Josifek, L F, Self, S G

“…The pathogenesis of myasthenia gravis involves a humorally mediated autoimmune attack directed against acetylcholine receptors of skeletal muscles. Antibodies…”
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Myasthenic antibodies cross-link acetylcholine receptors to accelerate degradation by Drachman, D B, Angus, C W, Adams, R N, Michelson, J D, Hoffman, G J

“…The decrease of acetylcholine receptors at neuromuscular junctions of myasthenic patients has been attributed to an antibody-mediated autoimmune process that…”
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Specific Immunotherapy by Genetically Engineered APCs: The "Guided Missile" Strategy by Wu, Bo, Wu, Jian-Ming, Miagkov, Alexei, Adams, Robert N, Levitsky, Hyam I, Drachman, Daniel B

“…We tested the hypothesis that APCs genetically engineered to present an Ag and to express Fas ligand (FasL) simultaneously can target and eliminate Ag-specific…”
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Production and Characterization of a T Cell Receptor Transgenic Mouse Recognizing the Immunodominant Epitope of the Torpedo californica Acetylcholine Receptor by MIAGKOV, ALEXEI, LOBITO, ADRIAN A., YANG, BINGZHI, LOPES, MARCELA F., ADAMS, ROBERT N., PALARDY, GREGORY R., JOHNSON, MICHELE M., McFARLAND, HUGH I., LENARDO, MICHAEL J., DRACHMAN, DANIEL B.

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T cell receptor transgenic mice recognizing the immunodominant epitope of the Torpedo californica acetylcholine receptor by Lobito, Adrian A., Yang, Bingzhi, Lopes, Marcela F., Miagkov, Alexei, Adams, Robert N., Palardy, Gregory R., Johnson, Michele M., McFarland, Hugh I., Recher, Michael, Drachman, Daniel B., Lenardo, Michael J.

“…Myasthenia gravis (MG) is an autoimmune disease caused by T cell‐dependent antibody‐mediated reduction of acetylcholine receptors (AChR) at the neuromuscular…”
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Patterns of serum IgM antibodies to GM1 and GD1a gangliosides in amyotrophic lateral sclerosis by Pestronk, A, Adams, R N, Cornblath, D, Kuncl, R W, Drachman, D B, Clawson, L

“…We studied the incidence and clinical correlates of serum antibodies to GM1 and GD1a gangliosides in patients with classical amyotrophic lateral sclerosis…”
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Oral tolerance in myasthenia gravis by Drachman, D B, Okumura, S, Adams, R N, McIntosh, K R

“…Because of the antibody-mediated pathogenesis of MG, it is of particular interest to understand the effects of oral administration of the autoantigen AChR on…”
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Specific Immunotherapy of Experimental Myasthenia Gravis in Vitro: The “Guided Missile” Strategy by Wu, Jian-Ming, Wu, Bo, Miagkov, Alexei, Adams, Robert N., Drachman, Daniel B.

“…We describe a strategy for specific immunotherapy of myasthenia gravis (MG) based on genetic engineering of antigen presenting cells (APCs) to present the…”
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A novel therapy for myasthenia gravis by reducing the endocytosis of acetylcholine receptors by Kuncl, R W, Wittstein, I, Adams, R N, Wiggins, W W, Avila, O, Pestronk, A, McIntosh, K, Lucas, D, DeSilva, S, Lehar, M

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Mechanisms of acetylcholine receptor loss in myasthenia gravis by Drachman, D B, Adams, R N, Stanley, E F, Pestronk, A

“…The fundamental abnormality affecting the neuromuscular junctions of myasthenic patients is a reduction of available AChRs, due to an autoimmune attack…”
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Functional Activities of Anti-AChR Antibodies and Clinical Severity of Myasthenia Gravis: 5: 10:00 AM by DRACHMAN, DANIEL B., ADAMS, ROBERT N., JOSIFEK, LORRAINE F.

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Combined short-term immunotherapy for experimental autoimmune myasthenia gravis by Pestronk, A, Drachman, D B, Teoh, R, Adams, R N

“…A therapeutic strategy was designed to eliminate the humoral immune response to acetylcholine receptor (AChR) in ongoing experimental autoimmune myasthenia…”
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Autoantibodies to acetylcholine receptors in myasthenia gravis

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Treatment of ongoing experimental myasthenia gravis with short term high dose cyclophosphamide by Pestronk, A, Drachman, D B, Adams, R N

“…We have treated animals with an ongoing autoimmune disease, experimental autoimmune myasthenia gravis (EAMG), using a strategy designed to eliminate the…”
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Effect of Myasthenic Patients' Immunoglobulin on Acetylcholine Receptor Turnover: Selectivity of Degradation Process by Drachman, Daniel B., Angus, C. William, Adams, Robert N., Kao, Ing

“…Antibodies in the sera of patients with myasthenia gravis are believed to play an important role in the pathogenesis of the disorder. They have recently been…”
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Lymphocyte responsiveness to acetylcholine receptor in rats with experimental autoimmune myasthenia gravis by Noguchi, S A, Drachman, D B, Adams, R N, Hirsch, R L

“…We examined the time course of lymphocyte responsiveness to acetylcholine receptor (AChR) in rats with experimental autoimmune myasthenia gravis (EAMG). Rats…”
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Treatment of experimental myasthenia gravis with cyclosporin A by Drachman, D B, Adams, R N, McIntosh, K, Pestronk, A

“…Cyclosporin A (CsA) is an immunosuppressive agent that has recently been used to prevent rejection of transplanted tissues. The effects of CsA treatment of…”
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