Search Results - "Adams, Philip P"
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RNA-RNA Interactomes of ProQ and Hfq Reveal Overlapping and Competing Roles
Published in Molecular cell (16-01-2020)“…Base pairing RNAs modulate gene expression in all studied organisms. In many bacteria, the base pairing between most small regulatory RNAs (sRNAs) and their…”
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Prevalence of small base-pairing RNAs derived from diverse genomic loci
Published in Biochimica et biophysica acta. Gene regulatory mechanisms (01-07-2020)“…Small RNAs (sRNAs) that act by base-pairing have been shown to play important roles in fine-tuning the levels and translation of their target transcripts…”
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Extensive diversity in RNA termination and regulation revealed by transcriptome mapping for the Lyme pathogen Borrelia burgdorferi
Published in Nature communications (04-07-2023)“…Transcription termination is an essential and dynamic process that can tune gene expression in response to diverse molecular signals. Yet, the genomic…”
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Regulatory roles of Escherichia coli 5' UTR and ORF-internal RNAs detected by 3' end mapping
Published in eLife (18-01-2021)“…Many bacterial genes are regulated by RNA elements in their 5´ untranslated regions (UTRs). However, the full complement of these elements is not known even in…”
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BB0562 is a nutritional virulence determinant with lipase activity important for Borrelia burgdorferi infection and survival in fatty acid deficient environments
Published in PLoS pathogens (20-08-2021)“…The Lyme disease spirochete Borrelia burgdorferi relies on uptake of essential nutrients from its host environments for survival and infection. Therefore,…”
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A Dual Luciferase Reporter System for B. burgdorferi Measures Transcriptional Activity during Tick-Pathogen Interactions
Published in Frontiers in cellular and infection microbiology (31-05-2017)“…Knowledge of the transcriptional responses of vector-borne pathogens at the vector-pathogen interface is critical for understanding disease transmission. ( ) ,…”
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In vivo expression technology and 5' end mapping of the Borrelia burgdorferi transcriptome identify novel RNAs expressed during mammalian infection
Published in Nucleic acids research (25-01-2017)“…Borrelia burgdorferi, the bacterial pathogen responsible for Lyme disease, modulates its gene expression profile in response to the environments encountered…”
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Borrelia burgdorferi bbk13 Is Critical for Spirochete Population Expansion in the Skin during Early Infection
Published in Infection and immunity (01-05-2019)“…Lyme disease is caused by the spirochete and is transmitted via the bite of an infected tick. enters the skin, disseminates via the bloodstream, and infects…”
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Gene bb0318 Is Critical for the Oxidative Stress Response and Infectivity of Borrelia burgdorferi
Published in Infection and immunity (01-11-2016)“…A greater understanding of the molecular mechanisms that Borrelia burgdorferi uses to survive during mammalian infection is critical for the development of…”
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Selection of Borrelia burgdorferi Promoter Sequences Active During Mammalian Infection Using In Vivo Expression Technology
Published in Methods in molecular biology (Clifton, N.J.) (01-01-2018)“…In vivo expression technology (IVET) has been applied to a variety of organisms to identify active promoters in specific environments or growth conditions of…”
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Correction: Regulatory roles of Escherichia coli 5' UTR and ORF-internal RNAs detected by 3' end mapping
Published in eLife (13-04-2021)Get full text
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