Search Results - "Adams, Nathan B. P."

Transporter characterisation reveals aminoethylphosphonate mineralisation as a key step in the marine phosphorus redox cycle by Murphy, Andrew R. J., Scanlan, David J., Chen, Yin, Adams, Nathan B. P., Cadman, William A., Bottrill, Andrew, Bending, Gary, Hammond, John P., Hitchcock, Andrew, Wellington, Elizabeth M. H., Lidbury, Ian D. E. A.

“…The planktonic synthesis of reduced organophosphorus molecules, such as alkylphosphonates and aminophosphonates, represents one half of a vast global oceanic…”
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Nanomechanical and Thermophoretic Analyses of the Nucleotide-Dependent Interactions between the AAA+ Subunits of Magnesium Chelatase by Adams, Nathan B. P, Vasilev, Cvetelin, Brindley, Amanda A, Hunter, C. Neil

“…In chlorophyll biosynthesis, the magnesium chelatase enzyme complex catalyzes the insertion of a Mg2+ ion into protoporphyrin IX. Prior to this event, two of…”
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The molecular basis of phosphite and hypophosphite recognition by ABC-transporters by Bisson, Claudine, Adams, Nathan B. P., Stevenson, Ben, Brindley, Amanda A., Polyviou, Despo, Bibby, Thomas S., Baker, Patrick J., Hunter, C. Neil, Hitchcock, Andrew

“…Inorganic phosphate is the major bioavailable form of the essential nutrient phosphorus. However, the concentration of phosphate in most natural habitats is…”
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The active site of magnesium chelatase by Adams, Nathan B. P., Bisson, Claudine, Brindley, Amanda A., Farmer, David A., Davison, Paul A., Reid, James D., Hunter, C. Neil

“…The insertion of magnesium into protoporphyrin initiates the biosynthesis of chlorophyll, the pigment that underpins photosynthesis. This reaction, catalysed…”
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Improved 2,4-Diarylthiazole-Based Antiprion Agents: Switching the Sense of the Amide Group at C5 Leads to an Increase in Potency by Thompson, Mark J., Louth, Jennifer C., Greenwood, Gemma K., Sorrell, Fiona J., Knight, Sandra G., Adams, Nathan B. P., Chen, Beining

“…Amide derivatives of 2,4‐diarylthiazole‐5‐carboxylic acids were synthesised and tested for efficacy in a cell line model of prion disease. A number of…”
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How the O2-dependent Mg-protoporphyrin monomethyl ester cyclase forms the fifth ring of chlorophylls by Chen, Guangyu E., Adams, Nathan B. P., Jackson, Philip J., Dickman, Mark J., Hunter, C. Neil

“…Mg-protoporphyrin IX monomethyl ester (MgPME) cyclase catalyses the formation of the isocyclic ring, producing protochlorophyllide  a and contributing…”
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The Allosteric Role of the AAA+ Domain of ChlD Protein from the Magnesium Chelatase of Synechocystis Species PCC 6803 by Adams, Nathan B.P., Reid, James D.

“…Magnesium chelatase catalyzes the first essential step in chlorophyll biosynthesis. Results: Mutations in the AAA+ domain of the magnesium chelatase ChlD…”
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Nonequilibrium Isotope Exchange Reveals a Catalytically Significant Enzyme–Phosphate Complex in the ATP Hydrolysis Pathway of the AAA+ ATPase Magnesium Chelatase by Adams, Nathan B. P, Reid, James D

“…Magnesium chelatase is an AAA+ ATPase that catalyzes the first committed step in chlorophyll biosynthesis. Using nonequilibrium isotope exchange, we show that…”
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Characterization of the magnesium chelatase from Thermosynechococcus elongatus by Adams, Nathan B P, Marklew, Christopher J, Brindley, Amanda A, Hunter, C Neil, Reid, James D

“…The first committed step in chlorophyll biosynthesis is catalysed by magnesium chelatase (E.C. 6.6.1.1), which uses the free energy of ATP hydrolysis to insert…”
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Spray drying siRNA-lipid nanoparticles for dry powder pulmonary delivery by Zimmermann, Christoph M., Baldassi, Domizia, Chan, Karen, Adams, Nathan B.P., Neumann, Alina, Porras-Gonzalez, Diana Leidy, Wei, Xin, Kneidinger, Nikolaus, Stoleriu, Mircea Gabriel, Burgstaller, Gerald, Witzigmann, Dominik, Luciani, Paola, Merkel, Olivia M.

“…While all the siRNA drugs on the market target the liver, the lungs offer a variety of currently undruggable targets which could potentially be treated with…”
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Synthesis and Evaluation of Anticancer Natural Product Analogues Based on Angelmarin: Targeting the Tolerance towards Nutrient Deprivation by Magolan, Jakob, Adams, Nathan B. P., Onozuka, Hiroko, Hungerford, Natasha L., Esumi, Hiroyasu, Coster, Mark J.

“…Inspired by nature: Angelmarin is an anticancer natural product with potent antiausterity activity, that is, selective cytotoxicity towards nutrient‐deprived,…”
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The ChlD subunit links the motor and porphyrin binding subunits of magnesium chelatase by Farmer, David A, Brindley, Amanda A, Hitchcock, Andrew, Jackson, Philip J, Johnson, Bethany, Dickman, Mark J, Hunter, C Neil, Reid, James D, Adams, Nathan B P

“…Magnesium chelatase initiates chlorophyll biosynthesis, catalysing the MgATP -dependent insertion of a Mg ion into protoporphyrin IX. The catalytic core of…”
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Chlorophyll biosynthesis under the control of arginine metabolism by Kiss, Éva, Talbot, Jana, Adams, Nathan B.P., Opekar, Stanislav, Moos, Martin, Pilný, Jan, Kvasov, Tatjana, Schneider, Emilia, Koník, Peter, Šimek, Petr, Sobotka, Roman

“…In natural environments, photosynthetic organisms adjust their metabolism to cope with the fluctuating availability of combined nitrogen sources, a…”
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Phosphite binding by the HtxB periplasmic binding protein depends on the protonation state of the ligand by Adams, Nathan B. P., Robertson, Angus J., Hunter, C. Neil, Hitchcock, Andrew, Bisson, Claudine

“…Phosphorus acquisition is critical for life. In low phosphate conditions, some species of bacteria have evolved mechanisms to import reduced phosphorus…”
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Probing the quality control mechanism of the Escherichia coli twin-arginine translocase with folding variants of a de novo–designed heme protein by Sutherland, George A., Grayson, Katie J., Adams, Nathan B.P., Mermans, Daphne M.J., Jones, Alexander S., Robertson, Angus J., Auman, Dirk B., Brindley, Amanda A., Sterpone, Fabio, Tuffery, Pierre, Derreumaux, Philippe, Dutton, P. Leslie, Robinson, Colin, Hitchcock, Andrew, Hunter, C. Neil

“…Protein transport across the cytoplasmic membrane of bacterial cells is mediated by either the general secretion (Sec) system or the twin-arginine translocase…”
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The catalytic power of magnesium chelatase: a benchmark for the AAA+ ATPases by Adams, Nathan B. P., Brindley, Amanda A., Hunter, C. Neil, Reid, James D.

“…In the first committed reaction of chlorophyll biosynthesis, magnesium chelatase couples ATP hydrolysis to the thermodynamically unfavorable Mg2+ insertion…”
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Porphyrin Binding to Gun4 Protein, Facilitated by a Flexible Loop, Controls Metabolite Flow through the Chlorophyll Biosynthetic Pathway by Kopečná, Jana, Cabeza de Vaca, Israel, Adams, Nathan B.P., Davison, Paul A., Brindley, Amanda A., Hunter, C. Neil, Guallar, Victor, Sobotka, Roman

“…In oxygenic phototrophs, chlorophylls, hemes, and bilins are synthesized by a common branched pathway. Given the phototoxic nature of tetrapyrroles, this…”
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Five Glutamic Acid Residues in the C‑Terminal Domain of the ChlD Subunit Play a Major Role in Conferring Mg2+ Cooperativity upon Magnesium Chelatase by Brindley, Amanda A, Adams, Nathan B. P, Hunter, C. Neil, Reid, James D

“…Magnesium chelatase catalyzes the first committed step in chlorophyll biosynthesis by inserting a Mg2+ ion into protoporphyrin IX in an ATP-dependent manner…”
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Efficient and Targeted siRNA Delivery to M2 Macrophages by Smart Polymer Blends for M1 Macrophage Repolarization as a Promising Strategy for Future Cancer Treatment by Jürgens, David C., Winkeljann, Benjamin, Kolog Gulko, Miriam, Jin, Yao, Möller, Judith, Winkeljann, Joshua, Sheshachala, Sahana, Anger, Alina, Hörner, Andreas, Adams, Nathan B. P., Urbanetz, Nora, Merkel, Olivia M.

“…Cancer remains an issue on a global scale. It is estimated that nearly 10 million people succumbed to cancer worldwide in 2020. New treatment options are…”
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How the O 2 -dependent Mg-protoporphyrin monomethyl ester cyclase forms the fifth ring of chlorophylls by Chen, Guangyu E, Adams, Nathan B P, Jackson, Philip J, Dickman, Mark J, Hunter, C Neil

“…Mg-protoporphyrin IX monomethyl ester (MgPME) cyclase catalyses the formation of the isocyclic ring, producing protochlorophyllide a and contributing…”
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