Search Results - "Adams, Hillary L."

Developmental exposure to 2,3,7,8-tetrachlorodibenzo- p -dioxin may alter LH release patterns by abolishing sex differences in GABA/glutamate cell number and modifying the transcriptome of the male anteroventral periventricular nucleus by Sans, Javier Del Pino, Clements, Kelsey J, Suvorov, Alexander, Krishnan, Sudha, Adams, Hillary L, Petersen, Sandra L

“…Highlights • Neonatal TCDD exposure abolishes sex differences in AVPV GABA/Glutamate neuronal population. • TCDD likely regulates genes important for neuron…”
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A CD117-Amanitin Antibody Drug Conjugate (ADC) Effectively Depletes Human and Non-Human Primate Hematopoietic Stem and Progenitor Cells (HSPCs): targeted Non-Genotoxic Conditioning for Bone Marrow Transplant by Pearse, Bradley R., McDonough, Sean M., Proctor, Jennifer L., Panwar, Rajiv, Sarma, Ganapathy N, Kien, Lena, Dushime, Junia, Adams, Hillary L., Hyzy, Sharon L., Brooks, Melissa, Palchaudhuri, Rahul, Li, Qing, Sawant, Pranoti, Lamothe, Tahirih L, Jain, Nidhi, McDonagh, Charlotte F, Boitano, Anthony E., Cooke, Michael P.

“…Current regimens for patient preparation, or conditioning, prior to bone marrow transplantation (BMT) limit the use of this curative procedure due to…”
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Phenotype Does Not Always Equal Function: HDAC Inhibitors and UM171, but Not SR1, Lead to Rapid Upregulation of CD90 on Non-Engrafting CD34+CD90-Negative Human Cells by Goncalves, Kevin A., Hoban, Megan D., Proctor, Jennifer L., Adams, Hillary L., Hyzy, Sharon L., Boitano, Anthony E., Cooke, Michael P.

“…Background. The ability to expand human hematopoietic stem cells (HSCs) has the potential to improve outcomes in HSC transplantation and increase the dose of…”
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Aryl Hydrocarbon Receptor Antagonists Expand Adult Hematopoietic Stem Cells from Mobilized Peripheral Blood and Bone Marrow and Increase the Dose of CRISPR/Cas9 Gene-Edited NSG-Repopulating Cells by Hoban, Megan D., Goncalves, Kevin A., Proctor, Jennifer L., Adams, Hillary L., Hyzy, Sharon L., George, Katia S., Boitano, Anthony E., Cooke, Michael P.

“…Background. Gene modified hematopoietic stem cell (HSC) transplant is emerging as a promising approach to treat a variety of inherited genetic diseases, but…”
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Antibody Drug Conjugates Targeted to CD45 or CD117 Enable Allogeneic Hematopoietic Stem Cell Transplantation in Animal Models by Palchaudhuri, Rahul, Hyzy, Sharon L., Proctor, Jennifer L, Adams, Hillary L, Pearse, Bradley R, Sarma, Ganapathy, Aslanian, Sharon, Gillard, Geoff, Lamothe, Tahirih L, Burenkova, Olga, Brooks, Melissa L., Gabros, Andrew D, McDonagh, Charlotte F, Boitano, Anthony E., Cooke, Michael P.

“…Introduction Targeted antibody drug conjugates (ADCs) to mouse CD45 or mouse CD117 have recently been shown to effectively prepare immunocompetent mice for…”
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Non-Genotoxic Conditioning for Hematopoietic Stem Cell Transplant Using a Human Antibody Drug Conjugate Targeting C-KIT by Hartigan, Adam J., Pearse, Bradley R., McDonough, Sean M., Proctor, Jennifer L., Adams, Hillary L., McShea, Molly A., Hoban, Megan D., Panwar, Rajiv, Hyzy, Sharon L., Goncalves, Kevin A., Palchaudhuri, Rahul, Boitano, Anthony E., Cooke, Michael P.

“…For patients undergoing hematopoietic stem cell transplantation (HSCT), conditioning remains a primary source of transplant related morbidity and mortality and…”
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CD117-Amanitin Antibody Drug Conjugates Effectively Deplete Human and Non-Human Primate HSCs: Proof of Concept As a Targeted Strategy for Conditioning Patients for Bone Marrow Transplant by Pearse, Bradley R, McDonough, Sean M, Proctor, Jennifer L, Panwar, Rajiv, Sarma, Ganapathy, McShea, Molly A, Kien, Lena, Dushime, Junia, Adams, Hillary L, Hyzy, Sharon L., Brooks, Melissa L., Palchaudhuri, Rahul, Li, Qing, Kallen, Nathan M, Sawant, Pranoti, McDonagh, Charlotte F, Boitano, Anthony E., Cooke, Michael P.

“…Background: Genotoxic conditioning prior to allogeneic and autologous bone marrow transplantation (BMT) limits the use of these potentially curative treatments…”
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Single Doses of Antibody Drug Conjugates (ADCs) Targeted to CD117 or CD45 Have Potent In Vivo Anti-Leukemia Activity and Survival Benefit in Patient Derived AML Models by Proctor, Jennifer L, Hyzy, Sharon L., Adams, Hillary L, Brooks, Melissa L., Gabros, Andrew D, McDonough, Sean M, Kien, Lena, Aslanian, Sharon, Pearse, Bradley R, Palchaudhuri, Rahul, Li, Qing, Kallen, Nathan M, Sarma, Ganapathy, McShea, Molly A, Ladwig, Danielle, Dushime, Junia, Panwar, Rajiv, McDonagh, Charlotte F, Boitano, Anthony E., Cooke, Michael P.

“…Background. Allogeneic bone marrow transplant (BMT) is a potentially curative approach in patients with refractory or high risk hematologic malignancies, such…”
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Targeting CD45 with an Amanitin Antibody-Drug Conjugate Effectively Depletes Human HSCs and Immune Cells for Transplant Conditioning by Palchaudhuri, Rahul, Pearse, Bradley R, Proctor, Jennifer L, Hyzy, Sharon L., Aslanian, Sharon, McDonough, Sean M, Sarma, Ganapathy, Brooks, Melissa L., Bhat, Anjali, Ladwig, Danielle, McShea, Molly A, Kallen, Nathan M, Li, Qing, Panwar, Rajiv, Dushime, Junia, Sawant, Pranoti, Adams, Hillary L, Falahee, Patrick C., Lamothe, Tahirih L, Gabros, Andrew D, Kien, Lena, Gillard, Geoff, McDonagh, Charlotte F, Boitano, Anthony E., Cooke, Michael P.

“…Introduction Bone Marrow Transplant (BMT) is a potentially curative treatment for malignant and non-malignant blood disorders and has demonstrated impressive…”
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CD45-Targeted Antibody Drug Conjugate Plus Post Transplant Cytoxan Is Sufficient to Enable Allogeneic Bone Marrow Transplant in a Minor Mismatch Mouse Model by Hyzy, Sharon L., Palchaudhuri, Rahul, Proctor, Jennifer L., Pearse, Brad R., Sarma, Ganapathy N., Adams, Hillary L., Aslanian, Sharon, Gillard, Geoff O., Lamothe, Tahirih L., Burenkova, Olga, Brooks, Melissa, Gabros, Andrew D., McDonagh, Charlotte F., Boitano, Anthony E., Cooke, Michael P.

“…Bone Marrow Transplant (BMT) is a potentially curative treatment for malignant and non-malignant blood disorders. Current regimens for patient preparation, or…”
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Phenotype Does not Always Equal Function: HDAC Inhibitors and UM171, but not SR1, Lead to Rapid Upregulation of CD90 on Non-Engrafting CD34+CD90-Negative Human Cells by Goncalves, Kevin A., Hoban, Megan D., Proctor, Jennifer L., Adams, Hillary L., Hyzy, Sharon L., Boitano, Anthony E., Cooke, Michael P.

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632 - Phenotype Does not Always Equal Function: HDAC Inhibitors and UM171, but not SR1, Lead to Rapid Upregulation of CD90 on Non-Engrafting CD34+CD90-Negative Human Cells by Goncalves, Kevin A., Hoban, Megan D., Proctor, Jennifer L., Adams, Hillary L., Hyzy, Sharon L., Boitano, Anthony E., Cooke, Michael P.

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628 - Aryl Hydrocarbon Receptor Antagonists Expand Adult Hematopoietic Stem Cells From Mobilized Peripheral Blood and Bone Marrow and Increase the Dose of CRISPR/Cas9 Gene-Edited NSG-Repopulating Cells by Hoban, Megan D., Goncalves, Kevin A., Proctor, Jennifer L., George, Katia S., Adams, Hillary L., Hyzy, Sharon L., Boitano, Anthony E., Cooke, Michael P.

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Aryl Hydrocarbon Receptor Antagonists Expand Adult Hematopoietic Stem Cells From Mobilized Peripheral Blood and Bone Marrow and Increase the Dose of CRISPR/Cas9 Gene-Edited NSG-Repopulating Cells by Hoban, Megan D., Goncalves, Kevin A., Proctor, Jennifer L., George, Katia S., Adams, Hillary L., Hyzy, Sharon L., Boitano, Anthony E., Cooke, Michael P.

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Non-Genotoxic Conditioning Using Amanitin Antibody-Drug Conjugates Targeting CD45 Effectively Deplete Human and Non-Human Primate Hematopoietic Stem Cells and Immune Cells by Palchaudhuri, Rahul, Pearse, Brad R., Proctor, Jennifer L., Hyzy, Sharon L., Aslanian, Sharon, Bhat, Anjali, Gillard, Geoff O, McDonough, Sean M., Sarma, Ganapathy N, Ladwig, Danielle, Li, Qing, Jain, Nidhi, Panwar, Rajiv, Sawant, Pranoti, Dushime, Junia, Falahee, Patrick C., Kien, Lena, Lamothe, Tahirih L, Gabros, Andrew D, Adams, Hillary L., McDonagh, Charlotte F, Boitano, Anthony E., Cooke, Michael P.

“…Bone Marrow Transplant (BMT) is a potentially curative treatment for malignant and non-malignant blood disorders. Current regimens for patient preparation, or…”
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Single Doses of Antibody Drug Conjugates (ADCs) Targeted to CD117 or CD45 Have Potent In Vivo Anti-Leukemia Activity and Survival Benefit in Patient Derived AML Models by Proctor, Jennifer L., Hyzy, Sharon L., Adams, Hillary L., Brooks, Melissa, Gabros, Andrew D., McDonough, Sean M., Kien, Lena, Aslanian, Sharon, Pearse, Bradley R., Palchaudhuri, Rahul, Li, Qing, Sarma, Ganapathy N., Ladwig, Danielle, Dushime, Junia, Panwar, Rajiv, McDonagh, Charlotte F., Boitano, Anthony E., Cooke, Michael P.

“…Allogeneic bone marrow transplant (BMT) is a potentially curative approach in patients with refractory or high-risk hematologic malignancies, like acute…”
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Single Doses of Antibody Drug Conjugates (ADCs) Targeted to CD117 or CD45 Have Potent In Vivo Anti-Leukemia Activity and Survival Benefit in Patient Derived AML Models by Proctor, Jennifer L., Hyzy, Sharon L., Adams, Hillary L., Brooks, Melissa, Gabros, Andrew D., McDonough, Sean M., Kien, Lena, Aslanian, Sharon, Pearse, Bradley R., Palchaudhuri, Rahul, Li, Qing, Sarma, Ganapathy N., Ladwig, Danielle, Dushime, Junia, Panwar, Rajiv, McDonagh, Charlotte F., Boitano, Anthony E., Cooke, Michael P.

“…Allogeneic bone marrow transplant (BMT) is a potentially curative approach in patients with refractory or high-risk hematologic malignancies, like acute…”
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A Non-Genotoxic Antibody Drug Conjugate Targeting C-Kit for Hematopoietic Stem Cell Transplant Conditioning by Hartigan, Adam J., Pearse, Brad R., McDonough, Sean M., Proctor, Jennifer L., Adams, Hillary L., McShea, Molly A., Hoban, Megan D., Panwar, Rajiv, Hyzy, Sharon L., Goncalves, Kevin A., Palchaudhuri, Rahul, Boitano, Anthony E., Cooke, Michael P.

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23 - A Non-Genotoxic Antibody Drug Conjugate Targeting C-Kit for Hematopoietic Stem Cell Transplant Conditioning by Hartigan, Adam J., Pearse, Brad R., McDonough, Sean M., Proctor, Jennifer L., Adams, Hillary L., McShea, Molly A., Hoban, Megan D., Panwar, Rajiv, Hyzy, Sharon L., Goncalves, Kevin A., Palchaudhuri, Rahul, Boitano, Anthony E., Cooke, Michael P.

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