Search Results - "Adams, Gregory P."

Influence of Affinity and Antigen Internalization on the Uptake and Penetration of Anti-HER2 Antibodies in Solid Tumors by RUDNICK, Stephen I, JIANLONG LOU, SHALLER, Calvin C, YONG TANG, KLEIN-SZANTO, Andres J. P, WEINER, Louis M, MARKS, James D, ADAMS, Gregory P

“…Antibody drugs are widely used in cancer therapy, but conditions to maximize tumor penetration and efficacy have yet to be fully elucidated. In this study, we…”
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Impact of intrinsic affinity on functional binding and biological activity of EGFR antibodies by Zhou, Yu, Goenaga, Anne-Laure, Harms, Brian D, Zou, Hao, Lou, Jianlong, Conrad, Fraser, Adams, Gregory P, Schoeberl, Birgit, Nielsen, Ulrik B, Marks, James D

“…Aberrant expression and activation of EGF receptor (EGFR) has been implicated in the development and progression of many human cancers. As such, targeted…”
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Broadening of neutralization activity to directly block a dominant antibody-driven SARS-coronavirus evolution pathway by Sui, Jianhua, Aird, Daniel R, Tamin, Azaibi, Murakami, Akikazu, Yan, Meiying, Yammanuru, Anuradha, Jing, Huaiqi, Kan, Biao, Liu, Xin, Zhu, Quan, Yuan, Qing-An, Adams, Gregory P, Bellini, William J, Xu, Jianguo, Anderson, Larry J, Marasco, Wayne A

“…Phylogenetic analyses have provided strong evidence that amino acid changes in spike (S) protein of animal and human SARS coronaviruses (SARS-CoVs) during and…”
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Targeting C4-demethylating genes in the cholesterol pathway sensitizes cancer cells to EGF receptor inhibitors via increased EGF receptor degradation by Sukhanova, Anna, Gorin, Andrey, Serebriiskii, Ilya G, Gabitova, Linara, Zheng, Hui, Restifo, Diana, Egleston, Brian L, Cunningham, David, Bagnyukova, Tetyana, Liu, Hanqing, Nikonova, Anna, Adams, Gregory P, Zhou, Yan, Yang, Dong-Hua, Mehra, Ranee, Burtness, Barbara, Cai, Kathy Q, Klein-Szanto, Andres, Kratz, Lisa E, Kelley, Richard I, Weiner, Louis M, Herman, Gail E, Golemis, Erica A, Astsaturov, Igor

“…Persistent signaling by the oncogenic EGF receptor (EGFR) is a major source of cancer resistance to EGFR targeting. We established that inactivation of 2…”
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DeBouganin Diabody Fusion Protein Overcomes Drug Resistance to ADCs Comprised of Anti-Microtubule Agents by Chooniedass, Shilpa, Dillon, Rachelle L, Premsukh, Arjune, Hudson, Peter J, Adams, Gregory P, MacDonald, Glen C, Cizeau, Jeannick

“…Antibody drug conjugates (ADC), comprised of highly potent small molecule payloads chemically conjugated to a full-length antibody, represent a growing class…”
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Monoclonal Antibody Therapy for Cancer by Mehren, Margaret von, Adams, Gregory P, Weiner, Louis M

“…Monoclonal antibody therapy has emerged as an important therapeutic modality for cancer. Unconjugated antibodies show significant efficacy in the treatment of…”
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Anti-CD70 immunocytokines for exploitation of interferon-γ-induced RIP1-dependent necrosis in renal cell carcinoma by Chen, Peirong, Nogusa, Shoko, Thapa, Roshan J, Shaller, Calvin, Simmons, Heidi, Peri, Suraj, Adams, Gregory P, Balachandran, Siddharth

“…Metastatic renal cell carcinoma (RCC) is an incurable disease in clear need of new therapeutic interventions. In early-phase clinical trials, the cytokine…”
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Avidity-Mediated Enhancement of In vivo Tumor Targeting by Single-Chain Fv Dimers by ADAMS, Gregory P, TAI, Mei-Sheng, MCCARTNEY, John E, MARKS, James D, STAFFORD, Walter F, HOUSTON, L. L, HUSTON, James S, WEINER, Louis M

“…Radiolabeled single-chain Fv (sFv) molecules display highly specific tumor retention in the severe combined immunodeficient (SCID) mouse model; however, the…”
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Effective Treatment of Established Human Breast Tumor Xenografts in Immunodeficient Mice with a Single Dose of the α-Emitting Radioisotope Astatine-211 Conjugated to Anti-HER2/neu Diabodies by ROBINSON, Matthew K, SHALLER, Calvin, GARMESTANI, Kayhan, PLASCJAK, Paul S, HODGE, Kathryn M, YUAN, Qing-An, MARKS, James D, WALDMANN, Thomas A, BRECHBIE, Martin W, ADAMS, Gregory P

“…Purpose: Successful radioimmunotherapy strategies depend on selecting radioisotopes with physical properties complementary to the biological properties of the…”
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Monoclonal antibody therapy of cancer by Weiner, Louis M, Adams, Gregory P

“…The most significant recent advances in the application of monoclonal antibodies (mAbs) to oncology have been the introduction and approval of bevacizumab…”
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Cellular studies of binding, internalization and retention of a radiolabeled EGFR-binding affibody molecule by Nordberg, Erika, Friedman, Mikaela, Göstring, Lovisa, Adams, Gregory P, Brismar, Hjalmar, Nilsson, Fredrik Y, Ståhl, Stefan, Glimelius, Bengt, Carlsson, Jörgen

“…Abstract Introduction The cellular binding and processing of an epidermal growth factor receptor (EGFR) targeting affibody molecule, (ZEGFR:955 )2 , was…”
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A rapid method to regenerate piezoelectric microcantilever sensors (PEMS) by Loo, LiNa, Wu, Wei, Shih, Wan Y, Shih, Wei-Heng, Borghaei, Hossein, Pourrezaei, Kambiz, Adams, Gregory P

“…Piezoelectric microcantilever sensors (PEMS) can be sensitive tools for the detection of proteins and cells in biological fluids. However, currently available…”
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A single treatment of yttrium-90-labeled CHX-A-c6.5 diabody inhibits the growth of established human tumor xenografts in immunodeficient mice by ADAMS, Gregory P, SHALLER, Calvin C, DADACHOVA, Ekaterina, SIMMONS, Heidi H, HORAK, Eva M, TESFAYE, Abohawariat, KLEIN-SZANTO, Andres J. P, MARKS, James D, BRECHBIEL, Martin W, WEINER, Louis M

“…Antitumor diabody molecules are noncovalent single-chain Fv dimers that recapitulate the divalent binding properties of native IgG antibodies. Diabodies are…”
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Ultrasmall Folate Receptor Alpha Targeted Enzymatically Cleavable Silica Nanoparticle Drug Conjugates Augment Penetration and Therapeutic Efficacy in Models of Cancer by Wu, Fei, Chen, Pei-Ming, Gardinier, Thomas C., Turker, Melik Z., Venkatesan, Aranapakam M., Patel, Vaibhav, Khor, Tin, Bradbury, Michelle S., Wiesner, Ulrich B., Adams, Gregory P., Germano, Geno, Chen, Feng, Ma, Kai

“…To address the key challenges in the development of next-generation drug delivery systems (DDS) with desired physicochemical properties to overcome limitations…”
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Affinity and avidity in antibody-based tumor targeting by Rudnick, Stephen I, Adams, Gregory P

“…Many factors contribute to successful tumor targeting by antibodies. Besides properties of the tumor tissue and general antibody pharmacology, a relationship…”
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CAR T Cells Targeting MISIIR for the Treatment of Ovarian Cancer and Other Gynecologic Malignancies by Rodriguez-Garcia, Alba, Sharma, Prannda, Poussin, Mathilde, Boesteanu, Alina C., Minutolo, Nicholas G., Gitto, Sarah B., Omran, Dalia K., Robinson, Matthew K., Adams, Gregory P., Simpkins, Fiona, Powell, Daniel J.

“…The prognosis of patients diagnosed with advanced ovarian or endometrial cancer remains poor, and effective therapeutic strategies are limited. The Müllerian…”
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Interferon-γ-induced necrosis: an antitumor biotherapeutic perspective by Balachandran, Siddharth, Adams, Gregory P

“…Interferon (IFN)-γ-like the well-known antitumor biotherapeutic IFN-α-is a powerful antiproliferative and immune modulatory cytokine, but mixed results from…”
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Expression of single-chain Fv-Fc fusions in Pichia pastoris by Powers, David B., Amersdorfer, Peter, Poul, Marie-Alix, Nielsen, Ulrik B., Shalaby, M.Refaat, Adams, Gregory P., Weiner, Louis M., Marks, James D.

“…Phage display technology makes possible the direct isolation of monovalent single-chain Fv antibody fragments. For many applications, however, it is useful to…”
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Development of engineered antibodies specific for the Müllerian inhibiting substance type II receptor: a promising candidate for targeted therapy of ovarian cancer by Yuan, Qing-an, Simmons, Heidi H, Robinson, Matthew K, Russeva, Maria, Marasco, Wayne A, Adams, Gregory P

“…The Müllerian inhibiting substance type II receptor (MISIIR) is involved in Müllerian duct regression as part of the development of the male reproductive…”
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T Cell Activation by Antibody-Like Immunoreceptors: Increase in Affinity of the Single-Chain Fragment Domain above Threshold Does Not Increase T Cell Activation against Antigen-Positive Target Cells but Decreases Selectivity by Chmielewski, Markus, Hombach, Andreas, Heuser, Claudia, Adams, Gregory P, Abken, Hinrich

“…Chimeric TCRs with an Ab-derived binding domain confer predefined specificity and MHC-independent target binding to T cells for use in adoptive immunotherapy…”
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