Search Results - "Adams, Erin J."

The Intracellular B30.2 Domain of Butyrophilin 3A1 Binds Phosphoantigens to Mediate Activation of Human Vγ9Vδ2 T Cells by Sandstrom, Andrew, Peigné, Cassie-Marie, Léger, Alexandra, Crooks, James E., Konczak, Fabienne, Gesnel, Marie-Claude, Breathnach, Richard, Bonneville, Marc, Scotet, Emmanuel, Adams, Erin J.

“…In humans, Vγ9Vδ2 T cells detect tumor cells and microbial infections, including Mycobacterium tuberculosis, through recognition of small pyrophosphate…”
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The Adaptable Major Histocompatibility Complex (MHC) Fold: Structure and Function of Nonclassical and MHC Class I-Like Molecules by Adams, Erin J, Luoma, Adrienne M

“…The MHC fold is found in proteins that have a range of functions in the maintenance of an organism's health, from immune regulation to fat metabolism. Well…”
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Crystal Structure of Vδ1 T Cell Receptor in Complex with CD1d-Sulfatide Shows MHC-like Recognition of a Self-Lipid by Human γδ T Cells by Luoma, Adrienne M., Castro, Caitlin D., Mayassi, Toufic, Bembinster, Leslie A., Bai, Li, Picard, Damien, Anderson, Brian, Scharf, Louise, Kung, Jennifer E., Sibener, Leah V., Savage, Paul B., Jabri, Bana, Bendelac, Albert, Adams, Erin J.

“…The nature of the antigens recognized by γδ T cells and their potential recognition of major histocompatibility complex (MHC)-like molecules has remained…”
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RhoB Mediates Phosphoantigen Recognition by Vγ9Vδ2 T Cell Receptor by Sebestyen, Zsolt, Scheper, Wouter, Vyborova, Anna, Gu, Siyi, Rychnavska, Zuzana, Schiffler, Marleen, Cleven, Astrid, Chéneau, Coraline, van Noorden, Martje, Peigné, Cassie-Marie, Olive, Daniel, Lebbink, Robert Jan, Oostvogels, Rimke, Mutis, Tuna, Schuurhuis, Gerrit Jan, Adams, Erin J., Scotet, Emmanuel, Kuball, Jürgen

“…Human Vγ9Vδ2 T cells respond to tumor cells by sensing elevated levels of phosphorylated intermediates of the dysregulated mevalonate pathway, which is…”
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The Role of Mucosal Associated Invariant T Cells in Antimicrobial Immunity by Napier, Ruth J, Adams, Erin J, Gold, Marielle C, Lewinsohn, David M

“…Mucosal associated invariant T (MAIT) cells are an innate-like T cell subset prevalent in humans and distributed throughout the blood and mucosal sites. Human…”
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MAIT recognition of a stimulatory bacterial antigen bound to MR1 by López-Sagaseta, Jacinto, Dulberger, Charles L, McFedries, Amanda, Cushman, Mark, Saghatelian, Alan, Adams, Erin J

“…MR1-restricted mucosal-associated invariant T (MAIT) cells represent a subpopulation of αβ T cells with innate-like properties and limited TCR diversity. MAIT…”
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Sensing of Pyrophosphate Metabolites by Vγ9Vδ2 T Cells by Gu, Siyi, Nawrocka, Wioletta, Adams, Erin J

“…The predominant population of γδ T cells in human blood express a T cell receptor (TCR) composed of a Vγ9 (Vγ2 in an alternate nomenclature) and Vδ2 domains…”
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Ligand-induced segregation from large cell-surface phosphatases is a critical step in γδ TCR triggering by Li, Fenglei, Roy, Sobhan, Niculcea, Jacob, Gould, Keith, Adams, Erin J., Anton van der Merwe, P., Choudhuri, Kaushik

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Ligand-induced segregation from large cell-surface phosphatases is a critical step in γδ TCR triggering by Li, Fenglei, Roy, Sobhan, Niculcea, Jacob, Gould, Keith, Adams, Erin J., van der Merwe, P. Anton, Choudhuri, Kaushik

“…Gamma/delta (γδ) T cells are unconventional lymphocytes that recognize diverse ligands via somatically recombined T cell antigen receptors (γδ TCRs). The…”
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Biochemical patterns of antibody polyreactivity revealed through a bioinformatics-based analysis of CDR loops by Boughter, Christopher T, Borowska, Marta T, Guthmiller, Jenna J, Bendelac, Albert, Wilson, Patrick C, Roux, Benoit, Adams, Erin J

“…Antibodies are critical components of adaptive immunity, binding with high affinity to pathogenic epitopes. Antibodies undergo rigorous selection to achieve…”
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molecular basis for Mucosal-Associated Invariant T cell recognition of MR1 proteins by López-Sagaseta, Jacinto, Dulberger, Charles L, Crooks, James E, Parks, Chelsea D, Luoma, Adrienne M, McFedries, Amanda, Van Rhijn, Ildiko, Saghatelian, Alan, Adams, Erin J

“…Mucosal-associated invariant T (MAIT) cells are an evolutionarily conserved αβ T-cell lineage that express a semi-invariant T-cell receptor (TCR) restricted to…”
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Molecular basis of mycobacterial lipid antigen presentation by CD1c and its recognition by αβ T cells by Roy, Sobhan, Ly, Dalam, Li, Nan-Sheng, Altman, John D, Piccirilli, Joseph A, Moody, D Branch, Adams, Erin J

“…CD1c is a member of the group 1 CD1 family of proteins that are specialized for lipid antigen presentation. Despite high cell surface expression of CD1c on key…”
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Deaza-modification of MR1 ligands modulates recognition by MR1-restricted T cells by Jin, Haihong, Ladd, Nicole A., Peev, Andrew M., Swarbrick, Gwendolyn M., Cansler, Meghan, Null, Megan, Boughter, Christopher T., McMurtrey, Curtis, Nilsen, Aaron, Dobos, Karen M., Hildebrand, William H., Lewinsohn, Deborah A., Adams, Erin J., Lewinsohn, David M., Harriff, Melanie J.

“…MR1-restricted T (MR1T) cells recognize microbial small molecule metabolites presented on the MHC Class I-like molecule MR1 and have been implicated in early…”
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Recognition of lyso-phospholipids by human natural killer T lymphocytes by Fox, Lisa M, Cox, Daryl G, Lockridge, Jennifer L, Wang, Xiaohua, Chen, Xiuxu, Scharf, Louise, Trott, David L, Ndonye, Rachel M, Veerapen, Natacha, Besra, Gurdyal S, Howell, Amy R, Cook, Mark E, Adams, Erin J, Hildebrand, William H, Gumperz, Jenny E

“…Natural killer T (NKT) cells are a subset of T lymphocytes with potent immunoregulatory properties. Recognition of self-antigens presented by CD1d molecules is…”
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Molecular mechanism for differential recognition of membrane phosphatidylserine by the immune regulatory receptor Tim4 by Tietjen, Gregory T, Gong, Zhiliang, Chen, Chiu-Hao, Vargas, Ernesto, Crooks, James E, Cao, Kathleen D, Heffern, Charles T R, Henderson, J Michael, Meron, Mati, Lin, Binhua, Roux, Benot, Schlossman, Mark L, Steck, Theodore L, Lee, Ka Yee C, Adams, Erin J

“…Recognition of phosphatidylserine (PS) lipids exposed on the extracellular leaflet of plasma membranes is implicated in both apoptotic cell removal and immune…”
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The CD3 Conformational Change in the γδ T Cell Receptor Is Not Triggered by Antigens but Can Be Enforced to Enhance Tumor Killing by Dopfer, Elaine P., Hartl, Frederike A., Oberg, Hans-Heinrich, Siegers, Gabrielle M., Yousefi, O. Sascha, Kock, Sylvia, Fiala, Gina J., Garcillán, Beatriz, Sandstrom, Andrew, Alarcón, Balbino, Regueiro, Jose R., Kabelitz, Dieter, Adams, Erin J., Minguet, Susana, Wesch, Daniela, Fisch, Paul, Schamel, Wolfgang W.A.

“…Activation of the T cell receptor (TCR) by antigen is the key step in adaptive immunity. In the αβTCR, antigen induces a conformational change at the CD3…”
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The molecular basis for recognition of CD1d/α-galactosylceramide by a human non-Vα24 T cell receptor by López-Sagaseta, Jacinto, Kung, Jennifer E, Savage, Paul B, Gumperz, Jenny, Adams, Erin J

“…CD1d-mediated presentation of glycolipid antigens to T cells is capable of initiating powerful immune responses that can have a beneficial impact on many…”
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The Immutable Recognition of CD1d by Adams, Erin J., López-Sagaseta, Jacinto

“…CD1d presents lipid antigens to natural killer T cells. In this issue of Immunity, Wun et al. (2011) and Mallevaey et al. (2011) explore the molecular details…”
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Human gamma delta T cells: Evolution and ligand recognition by Adams, Erin J., Gu, Siyi, Luoma, Adrienne M.

“…•We review work on the evolution of primate V, D and J gene segments of γδ T cells.•We also review CD1d-lipid recognition of Vδ1+ γδ and αβ T cells.•Lastly we…”
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Structural elucidation of the m157 mouse cytomegalovirus ligand for Ly49 natural killer cell receptors by Adams, Erin J, Juo, Z. Sean, Venook, Rayna Takaki, Boulanger, Martin J, Arase, Hisashi, Lanier, Lewis L, Garcia, K. Christopher

“…Natural killer (NK) cells express activating and inhibitory receptors that, in concert, survey cells for proper expression of cell surface major…”
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