Search Results - "Adams, Christopher M."

Proteomics of Primary Cilia by Proximity Labeling by Mick, David U., Rodrigues, Rachel B., Leib, Ryan D., Adams, Christopher M., Chien, Allis S., Gygi, Steven P., Nachury, Maxence V.

“…While cilia are recognized as important signaling organelles, the extent of ciliary functions remains unknown because of difficulties in cataloguing proteins…”
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A Spatial Interactome Reveals the Protein Organization of the Algal CO2-Concentrating Mechanism by Mackinder, Luke C.M., Chen, Chris, Leib, Ryan D., Patena, Weronika, Blum, Sean R., Rodman, Matthew, Ramundo, Silvia, Adams, Christopher M., Jonikas, Martin C.

“…Approximately one-third of global CO2 fixation is performed by eukaryotic algae. Nearly all algae enhance their carbon assimilation by operating a…”
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Subunit order of eukaryotic TRiC/CCT chaperonin by cross-linking, mass spectrometry, and combinatorial homology modeling by Kalisman, Nir, Adams, Christopher M, Levitt, Michael

“…The TRiC/CCT chaperonin is a 1-MDa hetero-oligomer of 16 subunits that assists the folding of proteins in eukaryotes. Low-resolution structural studies…”
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Role of the Transcription Factor ATF4 in the Anabolic Actions of Insulin and the Anti-anabolic Actions of Glucocorticoids by Adams, Christopher M.

“…In most mammalian cells, insulin and glucocorticoids promote anabolism and catabolism, respectively. Whereas the opposing effects of insulin and…”
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Control of skeletal muscle atrophy in response to disuse: clinical/preclinical contentions and fallacies of evidence by Atherton, Philip J, Greenhaff, Paul L, Phillips, Stuart M, Bodine, Sue C, Adams, Christopher M, Lang, Charles H

“…Muscle wasting resulting wholly or in part from disuse represents a serious medical complication that, when prolonged, can increase morbidity and mortality…”
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Transcription factor ATF4 directs basal and stress-induced gene expression in the unfolded protein response and cholesterol metabolism in the liver by Fusakio, Michael E, Willy, Jeffrey A, Wang, Yongping, Mirek, Emily T, Al Baghdadi, Rana J T, Adams, Christopher M, Anthony, Tracy G, Wek, Ronald C

“…Disturbances in protein folding and membrane compositions in the endoplasmic reticulum (ER) elicit the unfolded protein response (UPR). Each of three UPR…”
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Ursolic acid increases skeletal muscle and brown fat and decreases diet-induced obesity, glucose intolerance and fatty liver disease by Kunkel, Steven D, Elmore, Christopher J, Bongers, Kale S, Ebert, Scott M, Fox, Daniel K, Dyle, Michael C, Bullard, Steven A, Adams, Christopher M

“…Skeletal muscle Akt activity stimulates muscle growth and imparts resistance to obesity, glucose intolerance and fatty liver disease. We recently found that…”
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mRNA Expression Signatures of Human Skeletal Muscle Atrophy Identify a Natural Compound that Increases Muscle Mass by Kunkel, Steven D., Suneja, Manish, Ebert, Scott M., Bongers, Kale S., Fox, Daniel K., Malmberg, Sharon E., Alipour, Fariborz, Shields, Richard K., Adams, Christopher M.

“…Skeletal muscle atrophy is a common and debilitating condition that lacks a pharmacologic therapy. To develop a potential therapy, we identified 63 mRNAs that…”
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Architecture of an RNA Polymerase II Transcription Pre-Initiation Complex by Murakami, Kenji, Elmlund, Hans, Kalisman, Nir, Bushnell, David A., Adams, Christopher M., Azubel, Maia, Elmlund, Dominika, Levi-Kalisman, Yael, Liu, Xin, Gibbons, Brian J., Levitt, Michael, Kornberg, Roger D.

“…The protein density and arrangement of subunits of a complete, 32-protein, RNA polymerase II (pol II) transcription pre-initiation complex (PIC) were…”
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Methods Matter: Standard Production Platforms for Recombinant AAV Produce Chemically and Functionally Distinct Vectors by Rumachik, Neil G., Malaker, Stacy A., Poweleit, Nicole, Maynard, Lucy H., Adams, Christopher M., Leib, Ryan D., Cirolia, Giana, Thomas, Dennis, Stamnes, Susan, Holt, Kathleen, Sinn, Patrick, May, Andrew P., Paulk, Nicole K.

“…Different approaches are used in the production of recombinant adeno-associated virus (rAAV). The two leading approaches are transiently transfected human…”
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Identification and Small Molecule Inhibition of an Activating Transcription Factor 4 (ATF4)-dependent Pathway to Age-related Skeletal Muscle Weakness and Atrophy by Ebert, Scott M., Dyle, Michael C., Bullard, Steven A., Dierdorff, Jason M., Murry, Daryl J., Fox, Daniel K., Bongers, Kale S., Lira, Vitor A., Meyerholz, David K., Talley, John J., Adams, Christopher M.

“…Aging reduces skeletal muscle mass and strength, but the underlying molecular mechanisms remain elusive. Here, we used mouse models to investigate molecular…”
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The proteome of cholesteryl-ester-enriched versus triacylglycerol-enriched lipid droplets by Khor, Victor K, Ahrends, Robert, Lin, Ye, Shen, Wen-Jun, Adams, Christopher M, Roseman, Ann Nomoto, Cortez, Yuan, Teruel, Mary N, Azhar, Salman, Kraemer, Fredric B

“…Within cells, lipids are stored in the form of lipid droplets (LDs), consisting of a neutral lipid core, surrounded by a phospholipid monolayer and an outer…”
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Biology of Activating Transcription Factor 4 (ATF4) and Its Role in Skeletal Muscle Atrophy by Ebert, Scott M, Rasmussen, Blake B, Judge, Andrew R, Judge, Sarah M, Larsson, Lars, Wek, Ronald C, Anthony, Tracy G, Marcotte, George R, Miller, Matthew J, Yorek, Mark A, Vella, Adrian, Volpi, Elena, Stern, Jennifer I, Strub, Matthew D, Ryan, Zachary, Talley, John J, Adams, Christopher M

“…Activating transcription factor 4 (ATF4) is a multifunctional transcription regulatory protein in the basic leucine zipper superfamily. ATF4 can be expressed…”
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p53 and ATF4 mediate distinct and additive pathways to skeletal muscle atrophy during limb immobilization by Fox, Daniel K, Ebert, Scott M, Bongers, Kale S, Dyle, Michael C, Bullard, Steven A, Dierdorff, Jason M, Kunkel, Steven D, Adams, Christopher M

“…Immobilization causes skeletal muscle atrophy via complex signaling pathways that are not well understood. To better understand these pathways, we investigated…”
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Atf4 Regulates Obesity, Glucose Homeostasis, and Energy Expenditure by Seo, Jin, Fortuno, 3rd, Edgardo S, Suh, Jae Myoung, Stenesen, Drew, Tang, Wei, Parks, Elizabeth J, Adams, Christopher M, Townes, Tim, Graff, Jonathan M

“…Atf4 Regulates Obesity, Glucose Homeostasis, and Energy Expenditure Jin Seo 1 , Edgardo S. Fortuno III 1 , Jae Myoung Suh 1 , Drew Stenesen 1 , Wei Tang 1 ,…”
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OPA1 deletion in brown adipose tissue improves thermoregulation and systemic metabolism via FGF21 by Pereira, Renata O, Marti, Alex, Olvera, Angela Crystal, Tadinada, Satya Murthy, Bjorkman, Sarah Hartwick, Weatherford, Eric Thomas, Morgan, Donald A, Westphal, Michael, Patel, Pooja H, Kirby, Ana Karina, Hewezi, Rana, Bùi Trân, William, García-Peña, Luis Miguel, Souvenir, Rhonda A, Mittal, Monika, Adams, Christopher M, Rahmouni, Kamal, Potthoff, Matthew J, Abel, E Dale

“…Adrenergic stimulation of brown adipocytes alters mitochondrial dynamics, including the mitochondrial fusion protein optic atrophy 1 (OPA1). However, direct…”
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Thbs1 regulates skeletal muscle mass in a TGFβ-Smad2/3-ATF4-dependent manner by Vanhoutte, Davy, Schips, Tobias G., Minerath, Rachel A., Huo, Jiuzhou, Kavuri, Naga Swathi Sree, Prasad, Vikram, Lin, Suh-Chin, Bround, Michael J., Sargent, Michelle A., Adams, Christopher M., Molkentin, Jeffery D.

“…Loss of muscle mass is a feature of chronic illness and aging. Here, we report that skeletal muscle-specific thrombospondin-1 transgenic mice (Thbs1 Tg) have…”
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ULK2 is essential for degradation of ubiquitinated protein aggregates and homeostasis in skeletal muscle by Fuqua, Jordan D., Mere, Caleb P., Kronemberger, Ana, Blomme, Jay, Bae, Dam, Turner, Kristen D., Harris, Matthew P., Scudese, Estevão, Edwards, Mitchell, Ebert, Scott M., Sousa, Luís G. O., Bodine, Sue C., Yang, Ling, Adams, Christopher M., Lira, Vitor A.

“…Basal protein turnover, which largely relies on the degradation of ubiquitinated substrates, is instrumental for maintenance of muscle mass and function…”
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Absence of anti-hypocretin receptor 2 autoantibodies in post pandemrix narcolepsy cases by Luo, Guo, Lin, Ling, Jacob, Louis, Bonvalet, Mélodie, Ambati, Aditya, Plazzi, Giuseppe, Pizza, Fabio, Leib, Ryan, Adams, Christopher M, Partinen, Markku, Mignot, Emmanuel Jean-Marie

“…A recent publication suggested molecular mimicry of a nucleoprotein (NP) sequence from A/Puerto Rico/8/1934 (PR8) strain, the backbone used in the construction…”
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ATF4 expression in thermogenic adipocytes is required for cold-induced thermogenesis in mice via FGF21-independent mechanisms by Bjorkman, Sarah H., Marti, Alex, Jena, Jayashree, García-Peña, Luis Miguel, Weatherford, Eric T., Kato, Kevin, Koneru, Jivan, Chen, Jason, Sood, Ayushi, Potthoff, Matthew J., Adams, Christopher M., Abel, E. Dale, Pereira, Renata O.

“…In brown adipose tissue (BAT), short-term cold exposure induces the activating transcription factor 4 (ATF4), and its downstream target fibroblast growth…”
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