Can a Biohybrid Patch Salvage Ventricular Function at a Late Time Point in the Post-Infarction Remodeling Process?

[Display omitted] •A simple, biohybrid patch made of polymer (PECUU) and ECM, without cellular components, was able to induce positive remodeling features when applied over chronic infarcts with severely dilated hearts and high cardiac function impairment in rats.•The remodeling benefit was particul...

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Bibliographic Details
Published in:	JACC. Basic to translational science Vol. 6; no. 5; pp. 447 - 463
Main Authors:	Silveira-Filho, Lindemberg M., Coyan, Garrett N., Adamo, Arianna, Luketich, Samuel K., Menallo, Giorgio, D’Amore, Antonio, Wagner, William R.
Format:	Journal Article
Language:	English
Published:	Elsevier Inc 01-05-2021 Elsevier
Subjects:	biomaterial cardiac patch left ventricular remodeling myocardial infarction Preclinical Research PBS cardiac patch EF EDA biomaterial M1 M2 SMA myocardial infarction MT LVEF LVdd PECUU AT1R LV FS ECM PEUU ESA LVFW LVsd left ventricular remodeling MI HF
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Summary:	[Display omitted] •A simple, biohybrid patch made of polymer (PECUU) and ECM, without cellular components, was able to induce positive remodeling features when applied over chronic infarcts with severely dilated hearts and high cardiac function impairment in rats.•The remodeling benefit was particularly notable in a subgroup of the sickest rats with very low initial ejection fraction in which the echocardiographic endpoints were found to improve after treatment.•This technological approach may hold promise for future translation to patients in a chronic scenario. A biohybrid patch without cellular components was implanted over large infarcted areas in severely dilated hearts. Nonpatched animals were assigned to control or losartan therapy. Patch-implanted animals responded with better morphological and functional echocardiographic endpoints, which were more evident in a subgroup of animals with very low pre-treatment ejection fraction (<35%). Patched animals also had smaller infarcts than both nonpatched groups. This simple approach could hold promise for clinical translation and be applied using minimally invasive procedures over the epicardium in a large set of patients to induce better ventricular remodeling, especially among those who are especially frail.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2452-302X 2452-302X
DOI:	10.1016/j.jacbts.2021.01.004