Association between plasma homocysteine levels and coronary artery disease: a population-based study in northern Greece

Association between plasma homocysteine levels and coronary artery disease: a population-based study in northern Greece

SUMMARY Objective: Elevated plasma total homocysteine (tHcy) levels constitute a risk factor for coronary artery disease (CAD). We prospectively examined the association of fasting tHcy levels in patients in Northern Greece who had established CAD. Patients and methods: Plasma fasting tHcy levels we...

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Published in:Current medical research and opinion Vol. 20; no. 2; pp. 175 - 180
Main Authors: Boufidou, Amalia I., Makedou, Areti D., Adamidis, Dimitrios N., Karvounis, Haralampos I., Gourassas, John T., Kesidis, Haralampos T., Makedou, Kali G., Papadopoulos, Christodoulos E., Parharidis, Georgios E., Louridas, Georgios E.
Format: Journal Article
Language:English
Published: England Informa UK Ltd 01-01-2004
Taylor & Francis
Informa Healthcare
Subjects:
Adult
Aged
Biomarkers
Case-Control Studies
Coronary artery disease
Coronary Disease - blood
Coronary Disease - epidemiology
Female
Greece - epidemiology
Homocysteine
Homocysteine - blood
Humans
Logistic Models
Male
Matched-Pair Analysis
Middle Aged
Multivariate Analysis
Prospective Studies
Risk factor
Risk Factors
Greece
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Summary:SUMMARY Objective: Elevated plasma total homocysteine (tHcy) levels constitute a risk factor for coronary artery disease (CAD). We prospectively examined the association of fasting tHcy levels in patients in Northern Greece who had established CAD. Patients and methods: Plasma fasting tHcy levels were measured in 42 patients with angiographically documented CAD and compared to 42 age-, sex-, BMI- and smoking habit-matched control subjects. We also determined the plasma vitamin B12, folic acid and lipoprotein levels in all patients and controls. Conventional risk factors for CAD were also estimated. Results: In a univariate analysis, tHcy (jumol/l) levels were higher in patients compared to controls almost reaching statistical significance (13 (7-41) vs 11.3 (4-39); p = 0.07). Multivariate analysis of conventional risk factors showed that tHcy levels were not an independent risk factor for CAD. However, tHcy levels were significantly higher in patients with a previous history of myocardial infarction compared to patients without such a history and to controls (15 (8.8-29) vs 11.7 (7-41); p = 0.007 and 15 (8.8-29) vs 11.3 (4-39); p = 0.002, respectively). Hyperhomocysteinaemia (> 15|imol/l) was detected in 35.7% of patients and 11.9% of controls (p < 0.05). Conclusions: In Northern Greece, plasma tHcy levels may not be an independent risk factor for CAD in patients with angiographically documented CAD. However, patients with CAD have a trend towards higher tHcy levels. Additionally, plasma tHcy levels may be associated with the development of myocardial infarction.
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ISSN:0300-7995
1473-4877
DOI:10.1185/030079903125002856