DNA Aptamers for the Functionalisation of DNA Origami Nanostructures

DNA Aptamers for the Functionalisation of DNA Origami Nanostructures

DNA origami has emerged in recent years as a powerful technique for designing and building 2D and 3D nanostructures. While the breadth of structures that have been produced is impressive, one of the remaining challenges, especially for DNA origami structures that are intended to carry out useful bio...

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Bibliographic Details
Published in:Genes Vol. 9; no. 12; p. 571
Main Authors: Sakai, Yusuke, Islam, Md Sirajul, Adamiak, Martyna, Shiu, Simon Chi-Chin, Tanner, Julian Alexander, Heddle, Jonathan Gardiner
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 23-11-2018
MDPI
Subjects:
Antibodies
Aptamers
Biosensors
Cancer therapies
Cell surface
Deoxyribonucleic acid
Design
DNA
Immobilization
Integration
Ligands
Microscopy
Nanoparticles
Nanotechnology
Review
targeted therapy
biosensor
aptamer
molecular robotics
DNA nanotechnology
DNA origami
drug delivery system
enzyme cascade
logic gate
protein nano array
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Summary:DNA origami has emerged in recent years as a powerful technique for designing and building 2D and 3D nanostructures. While the breadth of structures that have been produced is impressive, one of the remaining challenges, especially for DNA origami structures that are intended to carry out useful biomedical tasks in vivo, is to endow them with the ability to detect and respond to molecules of interest. Target molecules may be disease indicators or cell surface receptors, and the responses may include conformational changes leading to the release of therapeutically relevant cargo. Nucleic acid aptamers are ideally suited to this task and are beginning to be used in DNA origami designs. In this review, we consider examples of uses of DNA aptamers in DNA origami structures and summarise what is currently understood regarding aptamer-origami integration. We review three major roles for aptamers in such applications: protein immobilisation, triggering of structural transformation, and cell targeting. Finally, we consider future perspectives for DNA aptamer integration with DNA origami.
ISSN:2073-4425
2073-4425
DOI:10.3390/genes9120571