Search Results - "Adami, Antonella"

Use of gene-modified regulatory T-cells to control autoimmune and alloimmune pathology: Is now the right time? by Jethwa, Hannah, Adami, Antonella A, Maher, John

“…Abstract Adoptive immunotherapy using genetically targeted T-cells has recently begun to achieve impressive clinical impact in selected tumor types…”
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Antitumor Immunity: Easy as 1, 2, 3 with Monoclonal Bispecific Trifunctional Antibodies? by MAHER, John, ADAMI, Antonella A

“…Monoclonal antibodies occupy an increasing niche in the arsenal available to treat cancer. Several developments have rendered this the fastest growing sector…”
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Development and Validation of a Good Manufacturing Process for IL-4-Driven Expansion of Chimeric Cytokine Receptor-Expressing CAR T-Cells by van Schalkwyk, May C. I., van der Stegen, Sjoukje J. C., Bosshard-Carter, Leticia, Graves, Helen, Papa, Sophie, Parente-Pereira, Ana C., Farzaneh, Farzin, Fisher, Christopher D., Hope, Andrew, Adami, Antonella, Maher, John

“…Adoptive cancer immunotherapy using chimeric antigen receptor (CAR) engineered T-cells holds great promise, although several obstacles hinder the efficient…”
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An overview of CAR T-cell clinical trial activity to 2021 by Adami, Antonella, Maher, John

“…Immunotherapy of cancer using chimeric antigen receptor-engineered T-cells has transformed the management of selected haematological malignancies, triggering…”
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Relationships between homocysteine, factor VIIa, and thrombin generation in acute coronary syndromes by AL-OBAIDI, M. K, PHILIPPOU, H, STUBBS, P. J, ADAMI, A, AMERSEY, R, NOBLE, M. M, LANE, D. A

“…It has been suggested by clinical, epidemiological, and experimental in vitro studies that homocysteine potentiates thrombin generation. This prothrombotic…”
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Tissue factor is rapidly elevated in plasma collected from the pericardial cavity during cardiopulmonary bypass by Philippou, H, Adami, A, Davidson, S J, Pepper, J R, Burman, J F, Lane, D A

“…There is growing evidence that the tissue factor/factor VIIa pathway of coagulation is enhanced during cardiopulmonary bypass. Hitherto, available evidence has…”
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A phase I trial of T4 CAR T-cell immunotherapy in head and neck squamous cancer (HNSCC) by Papa, Sophie, Adami, Antonella, Metoudi, Michael, Achkova, Daniela, van Schalkwyk, May, Parente Pereira, Ana, Bosshard-Carter, Leticia, Whilding, Lynsey, van der Stegen, Sjoukie, Davies, David, Farzaneh, Farzin, Guerrero Urbano, Teresa, Jeannon, Jean-Pierre, Spicer, James F., Maher, John

“…Abstract only…”
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Intratumoral pan-ErbB targeted CAR-T for head and neck squamous cell carcinoma: interim analysis of the T4 immunotherapy study by Papa, Sophie, Adami, Antonella, Metoudi, Michael, Beatson, Richard, George, Molly Sarah, Achkova, Daniela, Williams, Evangelia, Arif, Sefina, Reid, Fiona, Elstad, Maria, Beckley-Hoelscher, Nicholas, Douri, Abdel, Delord, Marc, Lyne, Mike, Shivapatham, Dharshene, Fisher, Christopher, Hope, Andrew, Gooljar, Sakina, Mitra, Arindam, Gomm, Linda, Morton, Cienne, Henley-Smith, Rhonda, Thavaraj, Selvam, Santambrogio, Alice, Andoniadou, Cynthia, Allen, Sarah, Gibson, Victoria, Cook, Gary J R, Parente-Pereira, Ana C, Davies, David M, Farzaneh, Farzin, Schurich, Anna, Guerrero-Urbano, Teresa, Jeannon, Jean-Pierre, Spicer, James, Maher, John

“…BackgroundLocally advanced/recurrent head and neck squamous cell carcinoma (HNSCC) is associated with significant morbidity and mortality. To target…”
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Abstract CT118: T4 immunotherapy of head and neck squamous cell carcinoma using pan-ErbB targeted CAR T-cells by Papa, Sophie, Adami, Antonella, Metoudi, Michael, Achkova, Daniela, Schalkwyk, May van, Pereira, Ana Parente, Bosshard-Carter, Leticia, Whilding, Lynsey, Stegen, Sjoukje van der, Davies, David M., Guerrero-Urbano, Teresa, Jeannon, Jean Pierre, Spicer, James, Maher, John

“…Striking progress has been achieved in CD19+ hematologic malignancies using chimeric antigen receptor (CAR) T-cells following lymphodepletion. Nonetheless,…”
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TGF-β1 potentiates Vγ9Vδ2 T cell adoptive immunotherapy of cancer by Beatson, Richard E., Parente-Pereira, Ana C., Halim, Leena, Cozzetto, Domenico, Hull, Caroline, Whilding, Lynsey M., Martinez, Olivier, Taylor, Chelsea A., Obajdin, Jana, Luu Hoang, Kim Ngan, Draper, Benjamin, Iqbal, Ayesha, Hardiman, Tom, Zabinski, Tomasz, Man, Francis, de Rosales, Rafael T.M., Xie, Jinger, Aswad, Fred, Achkova, Daniela, Joseph, Chung-Yang Ricardo, Ciprut, Sara, Adami, Antonella, Roider, Helge G., Hess-Stumpp, Holger, Győrffy, Balázs, Quist, Jelmar, Grigoriadis, Anita, Sommer, Anette, Tutt, Andrew N.J., Davies, David M., Maher, John

“…Despite its role in cancer surveillance, adoptive immunotherapy using γδ T cells has achieved limited efficacy. To enhance trafficking to bone marrow,…”
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Naturally occurring mutations in the thrombomodulin gene leading to impaired expression and function by Kunz, Gabriella, Öhlin, Ann-Kristin, Adami, Antonella, Zöller, Bengt, Svensson, Peter, Lane, David A.

“…Sporadic mutations in the thrombomodulin (TM) gene occur in patients with both arterial and venous thrombosis, but the effects of these mutations on expression…”
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A novel specific immunoassay for plasma two-chain factor VIIa : Investigation of FVIIa levels in normal individuals and in patients with acute coronary syndromes by PHILIPPOU, H, ADAMI, A, AMERSEY, R. A, STUBBS, P. J, LANE, D. A

“…We report the development of an enzyme-linked immunosorbent assay (ELISA) that is specific for factor VIIa (FVIIa). This assay uses a neoantigen specific…”
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