Search Results - "Adam, Ryan J"

Assessing mucociliary transport of single particles in vivo shows variable speed and preference for the ventral trachea in newborn pigs by Hoegger, Mark J., Awadalla, Maged, Namati, Eman, Itani, Omar A., Fischer, Anthony J., Tucker, Alexander J., Adam, Ryan J., McLennan, Geoffrey, Hoffman, Eric A., Stoltz, David A., Welsh, Michael J.

“…Mucociliary transport (MCT) is an innate defense mechanism that removes particulates, noxious material, and microorganisms from the lung. Several airway…”
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Acid-Sensing Ion Channel 1a Contributes to Airway Hyperreactivity in Mice by Reznikov, Leah R, Meyerholz, David K, Adam, Ryan J, Abou Alaiwa, Mahmoud, Jaffer, Omar, Michalski, Andrew S, Powers, Linda S, Price, Margaret P, Stoltz, David A, Welsh, Michael J

“…Neurons innervating the airways contribute to airway hyperreactivity (AHR), a hallmark feature of asthma. Several observations suggested that acid-sensing ion…”
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Rescue of impaired sympatholysis in older adults by exogenous administration of endothelium‐dependent vasodilatory signal by Adam, Ryan J.

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Integrin α6β4 identifies human distal lung epithelial progenitor cells with potential as a cell-based therapy for cystic fibrosis lung disease by Li, Xiaopeng, Rossen, Nathan, Sinn, Patrick L, Hornick, Andrew L, Steines, Benjamin R, Karp, Philip H, Ernst, Sarah E, Adam, Ryan J, Moninger, Thomas O, Levasseur, Dana N, Zabner, Joseph

“…To develop stem/progenitor cell-based therapy for cystic fibrosis (CF) lung disease, it is first necessary to identify markers of human lung epithelial…”
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Comparison of the surgical resection and infarct 5/6 nephrectomy rat models of chronic kidney disease by Adam, Ryan J, Williams, Adaysha C, Kriegel, Alison J

“…The 5/6 nephrectomy rat remnant kidney model is commonly used to study chronic kidney disease (CKD). This model requires the removal of one whole kidney and…”
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Restoring Cystic Fibrosis Transmembrane Conductance Regulator Function Reduces Airway Bacteria and Inflammation in People with Cystic Fibrosis and Chronic Lung Infections by Hisert, Katherine B, Heltshe, Sonya L, Pope, Christopher, Jorth, Peter, Wu, Xia, Edwards, Rachael M, Radey, Matthew, Accurso, Frank J, Wolter, Daniel J, Cooke, Gordon, Adam, Ryan J, Carter, Suzanne, Grogan, Brenda, Launspach, Janice L, Donnelly, Seamas C, Gallagher, Charles G, Bruce, James E, Stoltz, David A, Welsh, Michael J, Hoffman, Lucas R, McKone, Edward F, Singh, Pradeep K

“…Previous work indicates that ivacaftor improves cystic fibrosis transmembrane conductance regulator (CFTR) activity and lung function in people with cystic…”
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The role of neuroestrogens in the estrogen‐induced gonadotropin surge in male monkeys by Biswas, Mohammad S., Gelman, Erica M., Alexopoulos, Daniel J., Keen, Kim L., Adam, Ryan J., Terasawa, Ei

“…Neuroestrogens locally synthesized in the brain are known to play a role in sexual behaviors. However, the question of whether neuroestrogens are involved in…”
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Ovarian Hormone‐Dependent miR‐146b‐5p Regulation of Plasminogen Activator Inhibitor‐1 in Renal Epithelial Cells by Adam, Ryan J., Paterson, Mark R., Grzybowski, Michael N., Geurts, Aron M., Kriegel, Alison J.

“…Chronic kidney disease (CKD) progression differs in males and females and the influence of gonadal hormones on pathology are incompletely understood. We…”
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The magnitude and frequency of storm surge in southern New Zealand by Adam, Ryan J., Hilton, Michael J., Jowett, Tim, Stephenson, Wayne J.

“…There is currently little understanding regarding storm surge in New Zealand, particularly in the southern region. To date, there has been no attempt to…”
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Early Lung Disease Exhibits Bacteria-Dependent and -Independent Abnormalities in Cystic Fibrosis Pigs by Bouzek, Drake C, Abou Alaiwa, Mahmoud H, Adam, Ryan J, Pezzulo, Alejandro A, Reznikov, Leah R, Cook, Daniel P, Aguilar Pescozo, Maria I, Ten Eyck, Patrick, Wu, Chaorong, Gross, Thomas J, Hornick, Douglas B, Hoffman, Eric A, Meyerholz, David K, Stoltz, David A

“…Although it is clear that cystic fibrosis (CF) airway disease begins at a very young age, the early and subsequent steps in disease pathogenesis and the…”
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Macrophage activation in stellate ganglia contributes to lung injury‐induced arrhythmogenesis in male rats by Hong, Juan, Adam, Ryan J., Gao, Lie, Hahka, Taija, Xia, Zhiqiu, Wang, Dong, Nicholas, Thomas A., Zucker, Irving H., Lisco, Steven J., Wang, Han‐Jun

“…Aim Patients suffering from acute lung injury (ALI) are at high risk of developing cardiac arrhythmias. We hypothesized that stellate ganglia (SG) neural…”
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Lack of cystic fibrosis transmembrane conductance regulator disrupts fetal airway development in pigs by Meyerholz, David K., Stoltz, David A., Gansemer, Nick D., Ernst, Sarah E., Cook, Daniel P., Strub, Matthew D., LeClair, Erica N., Barker, Carrie K., Adam, Ryan J., Leidinger, Mariah R., Gibson-Corley, Katherine N., Karp, Philip H., Welsh, Michael J., McCray, Paul B.

“…Loss of cystic fibrosis transmembrane conductance regulator (CFTR) function causes cystic fibrosis (CF), predisposing the lungs to chronic infection and…”
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Cystic Fibrosis Transmembrane Conductance Regulator Potentiation as a Therapeutic Strategy for Pulmonary Edema: A Proof-of-Concept Study in Pigs by Li, Xiaopeng, Vargas Buonfiglio, Luis G., Adam, Ryan J., Stoltz, David A., Zabner, Joseph, Comellas, Alejandro P.

“…To determine the feasibility of using a cystic fibrosis transmembrane conductance regulator potentiator, ivacaftor (VX-770/Kalydeco, Vertex Pharmaceuticals,…”
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Intestinal CFTR expression alleviates meconium ileus in cystic fibrosis pigs by Stoltz, David A, Rokhlina, Tatiana, Ernst, Sarah E, Pezzulo, Alejandro A, Ostedgaard, Lynda S, Karp, Philip H, Samuel, Melissa S, Reznikov, Leah R, Rector, Michael V, Gansemer, Nicholas D, Bouzek, Drake C, Abou Alaiwa, Mahmoud H, Hoegger, Mark J, Ludwig, Paula S, Taft, Peter J, Wallen, Tanner J, Wohlford-Lenane, Christine, McMenimen, James D, Chen, Jeng-Haur, Bogan, Katrina L, Adam, Ryan J, Hornick, Emma E, Nelson, 4th, George A, Hoffman, Eric A, Chang, Eugene H, Zabner, Joseph, McCray, Jr, Paul B, Prather, Randall S, Meyerholz, David K, Welsh, Michael J

“…Cystic fibrosis (CF) pigs develop disease with features remarkably similar to those in people with CF, including exocrine pancreatic destruction, focal biliary…”
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Air Trapping and Airflow Obstruction in Newborn Cystic Fibrosis Piglets by ADAM, Ryan J, MICHALSKI, Andrew S, DIWAKAR, Amit, OCHS, Matthias, REINHARDT, Joseph M, HOFFMAN, Eric A, BEICHEL, Reinhard R, MEYERHOLZ, David K, STOLTZ, David A, BAUER, Christian, ABOU ALAIWA, Mahmoud H, CROSS, Thomas J, AWADALLA, Maged S, BOUZEK, Drake C, GANSEMER, Nicholas D, TAFT, Peter J, HOEGGER, Mark J

“…Air trapping and airflow obstruction are being increasingly identified in infants with cystic fibrosis. These findings are commonly attributed to airway…”
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Sympathoexcitation in response to cardiac and pulmonary afferent stimulation of TRPA1 channels is attenuated in rats with chronic heart failure by Adam, Ryan J, Xia, Zhiqiu, Pravoverov, Kristina, Hong, Juan, Case, Adam J, Schultz, Harold D, Lisco, Steven J, Zucker, Irving H, Wang, Han-Jun

“…Excessive sympathoexcitation characterizes the chronic heart failure (CHF) state. An exaggerated cardiac sympathetic afferent reflex (CSAR) contributes to this…”
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Tracheomalacia is associated with lower FEV1 and Pseudomonas acquisition in children with CF by Fischer, Anthony J., Singh, Sachinkumar B., Adam, Ryan J., Stoltz, David A., Baranano, Christopher F., Kao, Simon, Weinberger, Miles M., McCray Jr, Paul B., Starner, Timothy D.

“…Summary Background Tracheomalacia (TM) occurs in approximately 1 in 2,100 children. Because the trachea develops abnormally in animal models of cystic fibrosis…”
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Sonographic evidence of abnormal tracheal cartilage ring structure in cystic fibrosis by Diwakar, Amit, Adam, Ryan J., Michalski, Andrew S., Tamegnon, Monelle M., Fischer, Anthony J., Launspach, Jan L., Horan, Rebecca A., Kao, Simon C., Chaloner, Kathryn, Meyerholz, David K., Stoltz, David A.

“…Objectives/Hypothesis Tracheal cartilage ring structural abnormalities have been reported in cystic fibrosis (CF) mice and pigs. Whether similar findings are…”
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Functionally Essential Tubular Proteins Are Lost to Urine-Excreted, Large Extracellular Vesicles during Chronic Renal Insufficiency by Adam, Ryan J, Paterson, Mark R, Wardecke, Lukus, Hoffmann, Brian R, Kriegel, Alison J

“…The 5/6 nephrectomy (5/6Nx) rat model recapitulates many elements of human CKD. Within weeks of surgery, 5/6Nx rats spontaneously exhibit proximal tubular…”
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Postnatal airway growth in cystic fibrosis piglets by Adam, Ryan J, Abou Alaiwa, Mahmoud H, Bouzek, Drake C, Cook, Daniel P, Gansemer, Nicholas D, Taft, Peter J, Powers, Linda S, Stroik, Mallory R, Hoegger, Mark J, McMenimen, James D, Hoffman, Eric A, Zabner, Joseph, Welsh, Michael J, Meyerholz, David K, Stoltz, David A

“…Mutations in the gene encoding the cystic fibrosis (CF) transmembrane conductance regulator (CFTR) anion channel cause CF. The leading cause of death in the CF…”
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