Search Results - "Adam, M Gordian"

Inactivation of the serine protease HTRA1 inhibits tumor growth by deregulating angiogenesis by Klose, Ralph, Adam, M. Gordian, Weis, Eva-Maria, Moll, Iris, Wüstehube-Lausch, Joycelyn, Tetzlaff, Fabian, Oka, Chio, Ehrmann, Michael, Fischer, Andreas

“…The serine protease HTRA1 is involved in several vascular diseases and its expression is often deregulated in cancer. We aimed at identifying how HTRA1 in the…”
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Identification and validation of a multivariable prediction model based on blood plasma and serum metabolomics for the distinction of chronic pancreatitis subjects from non-pancreas disease control subjects by Adam, M Gordian, Beyer, Georg, Christiansen, Nicole, Kamlage, Beate, Pilarsky, Christian, Distler, Marius, Fahlbusch, Tim, Chromik, Ansgar, Klein, Fritz, Bahra, Marcus, Uhl, Waldemar, Grützmann, Robert, Mahajan, Ujjwal M, Weiss, Frank U, Mayerle, Julia, Lerch, Markus M

“…Chronic pancreatitis (CP) is a fibroinflammatory syndrome leading to organ dysfunction, chronic pain, an increased risk for pancreatic cancer and considerable…”
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Independent Validation and Assay Standardization of Improved Metabolic Biomarker Signature to Differentiate Pancreatic Ductal Adenocarcinoma From Chronic Pancreatitis by Mahajan, Ujjwal M., Oehrle, Bettina, Sirtl, Simon, Alnatsha, Ahmed, Goni, Elisabetta, Regel, Ivonne, Beyer, Georg, Vornhülz, Marlies, Vielhauer, Jakob, Chromik, Ansgar, Bahra, Markus, Klein, Fritz, Uhl, Waldemar, Fahlbusch, Tim, Distler, Marius, Weitz, Jürgen, Grützmann, Robert, Pilarsky, Christian, Weiss, Frank Ulrich, Adam, M. Gordian, Neoptolemos, John P., Kalthoff, Holger, Rad, Roland, Christiansen, Nicole, Bethan, Bianca, Kamlage, Beate, Lerch, Markus M., Mayerle, Julia

“…Pancreatic ductal adenocarcinoma cancer (PDAC) is a highly lethal malignancy requiring efficient detection when the primary tumor is still resectable. We…”
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MPDZ promotes DLL4-induced Notch signaling during angiogenesis by Tetzlaff, Fabian, Adam, M Gordian, Feldner, Anja, Moll, Iris, Menuchin, Amitai, Rodriguez-Vita, Juan, Sprinzak, David, Fischer, Andreas

“…Angiogenesis is coordinated by VEGF and Notch signaling. DLL4-induced Notch signaling inhibits tip cell formation and vessel branching. To ensure proper Notch…”
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Loss of Mpdz impairs ependymal cell integrity leading to perinatal‐onset hydrocephalus in mice by Feldner, Anja, Adam, M Gordian, Tetzlaff, Fabian, Moll, Iris, Komljenovic, Dorde, Sahm, Felix, Bäuerle, Tobias, Ishikawa, Hiroshi, Schroten, Horst, Korff, Thomas, Hofmann, Ilse, Wolburg, Hartwig, von Deimling, Andreas, Fischer, Andreas

“…Hydrocephalus is a common congenital anomaly. LCAM1 and MPDZ ( MUPP1 ) are the only known human gene loci associated with non‐syndromic hydrocephalus. To…”
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Human Metabolome Reference Database in a Biracial Cohort across the Adult Lifespan by Tian, Qu, Adam, M Gordian, Ozcariz, Enrique, Fantoni, Giovanna, Shehadeh, Nader M, Turek, Lisa M, Collingham, Victoria L, Kaileh, Mary, Moaddel, Ruin, Ferrucci, Luigi

“…As one of the OMICS in systems biology, metabolomics defines the metabolome and simultaneously quantifies numerous metabolites that are final or intermediate…”
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New Onset of DiabetEs in aSsociation with pancreatic ductal adenocarcinoma (NODES Trial): protocol of a prospective, multicentre observational trial by Illés, Dóra, Ivány, Emese, Holzinger, Gábor, Kosár, Klára, Adam, M Gordian, Kamlage, Beate, Zsóri, Gábor, Tajti, Máté, Svébis, Márk M, Horváth, Viktor, Oláh, Ilona, Márta, Katalin, Váncsa, Szilárd, Zádori, Noémi, Szentesi, Andrea, Czakó, Bálint, Hegyi, Péter, Czakó, László

“…IntroductionPancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis with an overall 5-year survival of approximately 8%. The success in reducing the…”
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Integrin Cytoplasmic Domain–Associated Protein-1 Attenuates Sprouting Angiogenesis by Brütsch, René, Liebler, Sven S, Wüstehube, Joycelyn, Bartol, Arne, Herberich, Stefanie E, Adam, M. Gordian, Telzerow, Anja, Augustin, Hellmut G, Fischer, Andreas

“…RATIONALE:The ICAP1 (integrin cytoplasmic domain–associated protein-1) is a specific intracellular binding protein of β1-integrins and the cerebral cavernous…”
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No evidence for a functional role of bi-directional Notch signaling during angiogenesis by Liebler, Sven S, Feldner, Anja, Adam, M Gordian, Korff, Thomas, Augustin, Hellmut G, Fischer, Andreas

“…The Delta-Notch pathway is a signal exchanger between adjacent cells to regulate numerous differentiation steps during embryonic development. Blood vessel…”
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Treatment With Hydrolyzed Diet Supplemented With Prebiotics and Glycosaminoglycans Alters Lipid Metabolism in Canine Inflammatory Bowel Disease by Ambrosini, Yoko M., Neuber, Sebastian, Borcherding, Dana, Seo, Yeon-Jung, Segarra, Sergi, Glanemann, Barbara, Garden, Oliver A., Müller, Udo, Adam, M. Gordian, Dang, Viet, Borts, David, Atherly, Todd, Willette, Auriel A., Jergens, Albert, Mochel, Jonathan P., Allenspach, Karin

“…Canine inflammatory bowel disease (IBD) is a chronic, immunologically mediated intestinal disorder, resulting from the complex interaction of genetic,…”
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Soluble Notch ligand and receptor peptides act antagonistically during angiogenesis by Klose, Ralph, Berger, Caroline, Moll, Iris, Adam, M Gordian, Schwarz, Frank, Mohr, Kerstin, Augustin, Hellmut G, Fischer, Andreas

“…Notch signalling is essential for blood vessel formation. During angiogenesis, the Notch ligand DLL4 on the leading tip cell activates Notch receptors on the…”
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SIAH ubiquitin ligases regulate breast cancer cell migration and invasion independent of the oxygen status by Adam, M Gordian, Matt, Sonja, Christian, Sven, Hess-Stumpp, Holger, Haegebarth, Andrea, Hofmann, Thomas G, Algire, Carolyn

“…Seven-in-absentia homolog (SIAH) proteins are evolutionary conserved RING type E3 ubiquitin ligases responsible for the degradation of key molecules regulating…”
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Synaptojanin-2 Binding Protein Stabilizes the Notch Ligands DLL1 and DLL4 and Inhibits Sprouting Angiogenesis by Adam, M Gordian, Berger, Caroline, Feldner, Anja, Yang, Wan-Jen, Wüstehube-Lausch, Joycelyn, Herberich, Stefanie E, Pinder, Marcel, Gesierich, Sabine, Hammes, Hans-Peter, Augustin, Hellmut G, Fischer, Andreas

“…RATIONALE:The formation of novel blood vessels is initiated by vascular endothelial growth factor. Subsequently, DLL4-Notch signaling controls the selection of…”
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SIAH ubiquitin ligases regulate breast cancer cell migration and invasion independent of the oxygen status by Adam, M Gordian, Matt, Sonja, Christian, Sven, Hess-Stumpp, Holger, Haegebarth, Andrea, Hofmann, Thomas G, Algire, Carolyn

“…Seven-in-absentia homolog (SIAH) proteins are evolutionary conserved RING type E3 ubiquitin ligases responsible for the degradation of key molecules regulating…”
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