Search Results - "Adam, Lucille"

Electroporation as a vaccine delivery system and a natural adjuvant to intradermal administration of plasmid DNA in macaques by Todorova, Biliana, Adam, Lucille, Culina, Slobodan, Boisgard, Raphaël, Martinon, Frédéric, Cosma, Antonio, Ustav, Mart, Kortulewski, Thierry, Le Grand, Roger, Chapon, Catherine

“…In vivo electroporation (EP) is used to enhance the uptake of nucleic acids and its association with DNA vaccination greatly stimulates immune responses to…”
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ß1-adrenergic blockers preserve neuromuscular function by inhibiting the production of extracellular traps during systemic inflammation in mice by Bourcier, Camille H., Michel-Flutot, Pauline, Emam, Laila, Adam, Lucille, Gasser, Adeline, Vinit, Stéphane, Mansart, Arnaud

“…Severe inflammation via innate immune system activation causes organ dysfunction. Among these, the central nervous system (CNS) is particularly affected by…”
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Strategies for Immunomonitoring after Vaccination and during Infection by Adam, Lucille, Rosenbaum, Pierre, Bonduelle, Olivia, Combadière, Behazine

“…Immunomonitoring is the study of an individual's immune responses over the course of vaccination or infection. In the infectious context, exploring the innate…”
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LOX-1-Expressing Immature Neutrophils Identify Critically-Ill COVID-19 Patients at Risk of Thrombotic Complications by Combadière, Behazine, Adam, Lucille, Guillou, Noëlline, Quentric, Paul, Rosenbaum, Pierre, Dorgham, Karim, Bonduelle, Olivia, Parizot, Christophe, Sauce, Delphine, Mayaux, Julien, Luyt, Charles-Edouard, Boissonnas, Alexandre, Amoura, Zahir, Pourcher, Valérie, Miyara, Makoto, Gorochov, Guy, Guihot, Amélie, Combadière, Christophe

“…BackgroundLymphopenia and the neutrophil/lymphocyte ratio may have prognostic value in COVID-19 severity. ObjectiveWe investigated neutrophil subsets and…”
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Amelioration of Compound 48/80-Mediated Itch and LL-37-Induced Inflammation by a Single-Stranded Oligonucleotide by Dondalska, Aleksandra, Rönnberg, Elin, Ma, Haisha, Pålsson, Sandra Axberg, Magnusdottir, Elin, Gao, Tianle, Adam, Lucille, Lerner, Ethan A, Nilsson, Gunnar, Lagerström, Malin, Spetz, Anna-Lena

“…Numerous inflammatory skin disorders display a high prevalence of itch. The Mas-related G protein coupled receptor X2 (MRGPRX2) has been shown to modulate itch…”
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Identification of skin immune cells in non-human primates by Adam, Lucille, Rosenbaum, Pierre, Cosma, Antonio, Le Grand, Roger, Martinon, Frédéric

“…The skin is a valuable target for vaccine delivery because it contains many immune cell populations, notably antigen presenting cells. Skin immune cells have…”
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Changes in the Immune Phenotype and Gene Expression Profile Driven by a Novel Tuberculosis Nanovaccine: Short and Long-Term Post-immunization by Martínez-Pérez, Amparo, Igea, Ana, Estévez, Olivia, Ferreira, Catarina M, Torrado, Egídio, Castro, António Gil, Fernández, Carmen, Spetz, Anna-Lena, Adam, Lucille, López González, Moisés, Singh, Mahavir, Reljic, Rajko, González-Fernández, África

“…Deciphering protection mechanisms against ( ) remains a critical challenge for the development of new vaccines and therapies. We analyze the phenotypic and…”
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Memory CD4+ T-Cell Lymphocytic Angiopathy in Fatal Forms of COVID-19 Pulmonary Infection by Guihot, Amélie, Plu, Isabelle, Soulié, Cathia, Rousseau, Alice, Nakid-Cordero, Cecilia, Dorgham, Karim, Parizot, Christophe, Litvinova, Elena, Mayaux, Julien, Malet, Isabelle, Quentric, Paul, Combadière, Béhazine, Combadière, Christophe, Bonduelle, Olivia, Adam, Lucille, Rosenbaum, Pierre, Beurton, Alexandra, Hémon, Patrice, Debré, Patrice, Vieillard, Vincent, Autran, Brigitte, Seilhean, Danielle, Charlotte, Frédéric, Marcelin, Anne-Geneviève, Gorochov, Guy, Luyt, Charles-Edouard

“…The immunopathological pulmonary mechanisms leading to Coronavirus Disease (COVID-19)-related death in adults remain poorly understood. Bronchoalveolar lavage…”
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CD8+PD-L1+CXCR3+ polyfunctional T cell abundances are associated with survival in critical SARS-CoV-2–infected patients by Adam, Lucille, Rosenbaum, Pierre, Quentric, Paul, Parizot, Christophe, Bonduelle, Olivia, Guillou, Noëlline, Corneau, Aurélien, Dorgham, Karim, Miyara, Makoto, Luyt, Charles-Edouard, Guihot, Amélie, Gorochov, Guy, Combadière, Christophe, Combadière, Behazine

“…The importance of the adaptive T cell response in the control and resolution of viral infection has been well established. However, the nature of T…”
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Early Resistance of Non-virulent Mycobacterial Infection in C57BL/6 Mice Is Associated With Rapid Up-Regulation of Antimicrobial Cathelicidin Camp by Adam, Lucille, López-González, Moisés, Björk, Albin, Pålsson, Sandra, Poux, Candice, Wahren-Herlenius, Marie, Fernández, Carmen, Spetz, Anna-Lena

“…Early clearance of tuberculosis is the successful eradication of inhaled bacteria before the development of an adaptive immune response. We previously showed,…”
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Modulation of neuromuscular function through extracellular traps in septic shock models by ADAM, Lucille, Bourcier, Camille, Emam, Laila, Vinit, Stéphane, Mansart, Arnaud

“…Sepsis via innate immune system activation causes organ dysfunction. Among these, the central nervous system (CNS) is particularly affected by…”
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B1-adrenergic blockers preserve motor function by inhibiting the production of extracellular traps by Bourcier, Camille, Michel-Flutot, Pauline, Emam, Laila, Adam, Lucille, Gasser, Adeline, Vinit, Stephane, Mansart, Arnaud

“…Abstract only Sepsis is characterized by a dysregulated host response to an infection, potentially leading to fatal organ dysfunctions. Among these organs, the…”
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B1-adrenergic blockers provide cardiac protection through extracellular traps inhibition during widespread inflammation by Mansart, Arnaud, Adam, Lucille, Gasser, Adeline, Bourcier, Camille, Vinit, Stephane, Annane, Djillali

“…Abstract only Sepsis is one of the leading causes of death worldwide, and no therapy is available other than intensive care treatments. Drug development…”
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ß1-adrenergic blockers preserve neuromuscular function by inhibiting the production of extracellular traps during systemic inflammation in mice by Bourcier, Camille H, Michel-Flutot, Pauline, Emam, Laila, Adam, Lucille, Gasser, Adeline, Vinit, Stéphane, Mansart, Arnaud

“…Severe inflammation via innate immune system activation causes organ dysfunction. Among these, the central nervous system (CNS) is particularly affected by…”
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Innate Molecular and Cellular Signature in the Skin Preceding Long-Lasting T Cell Responses after Electroporated DNA Vaccination by Adam, Lucille, Tchitchek, Nicolas, Todorova, Biliana, Rosenbaum, Pierre, Joly, Candie, Poux, Candice, Chapon, Catherine, Spetz, Anna-Lena, Ustav, Mart, Le Grand, Roger, Martinon, Frédéric

“…DNA vaccines delivered with electroporation (EP) have shown promising results in preclinical models and are evaluated in clinical trials. In this study, we aim…”
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The immunological effects of intradermal particle-based vaccine delivery using a novel microinjection needle studied in a human skin explant model by Beaujean, Manon, Uijen, Rienke F., Langereis, Jeroen D., Boccara, David, Dam, Denise, Soria, Angèle, Veldhuis, Gert, Adam, Lucille, Bonduelle, Olivia, van der Wel, Nicole N., Luirink, Joen, Pedruzzi, Eric, Wissink, Jeroen, de Jonge, Marien I., Combadière, Behazine

“…For intradermal (ID) immunisation, novel needle-based delivery systems have been proposed as a better alternative to the Mantoux method. However, the…”
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Innate Molecular and Cellular Signature in the Skin Preceding Long-Lasting T Cell Responses After Electroporated DNA Vaccination by Adam, Lucille, Tchitchek, Nicolas, Todorova, Biliana, Rosenbaum, Pierre, Joly, Candie, Poux, Candice, Chapon, Catherine, Spetz, Anna-Lena, Ustav, Mart, Le Grand, Roger, Martinon, Frédéric

“…DNA vaccines delivered with electroporation (EP) have shown promising results in preclinical models and are evaluated in clinical trials. In this study, we aim…”
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Innate Molecular and Cellular Signature in the Skin Preceding Long-Lasting T Cell Responses after Electroporated DNA Vaccination by Adam, Lucille, Tchitchek, Nicolas, Todorova, Biliana, Rosenbaum, Pierre, Joly, Candie, Poux, Candice, Chapon, Catherine, Spetz, Anna-Lena, Ustav, Mart, Le Grand, Roger, Martinon, Frédéric

“…Abstract DNA vaccines delivered with electroporation (EP) have shown promising results in preclinical models and are evaluated in clinical trials. In this…”
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Macrophage- and neutrophil-derived TNF-α instructs skin langerhans cells to prime antiviral immune responses by Epaulard, Olivier, Adam, Lucille, Poux, Candice, Zurawski, Gerard, Salabert, Nina, Rosenbaum, Pierre, Dereuddre-Bosquet, Nathalie, Zurawski, Sandra, Flamar, Anne-Laure, Oh, Sangkon, Romain, Gabrielle, Chapon, Catherine, Banchereau, Jacques, Lévy, Yves, Le Grand, Roger, Martinon, Frédéric

“…Dendritic cells are major APCs that can efficiently prime immune responses. However, the roles of skin-resident Langerhans cells (LCs) in eliciting immune…”
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CD34‐derived dendritic cells transfected ex vivo with HIV‐Gag mRNA induce polyfunctional T‐cell responses in nonhuman primates by Romain, Gabrielle, van Gulck, Ellen, Epaulard, Olivier, Oh, SangKon, Li, Dapeng, Zurawski, Gerard, Zurawski, Sandra, Cosma, Antonio, Adam, Lucille, Chapon, Catherine, Todorova, Biliana, Banchereau, Jacques, Dereuddre‐Bosquet, Nathalie, Vanham, Guido, Le Grand, Roger, Martinon, Frédéric

“…The pivotal role of DCs in initiating immune responses led to their use as vaccine vectors. However, the relationship between DC subsets involved in antigen…”
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