Search Results - "Acuña‐Castroviejo, Darío"

Extrapineal melatonin: analysis of its subcellular distribution and daily fluctuations by Venegas, Carmen, García, José A., Escames, Germaine, Ortiz, Francisco, López, Ana, Doerrier, Carolina, García-Corzo, Laura, López, Luis C., Reiter, Russel J., Acuña-Castroviejo, Darío

“…:  We studied the subcellular levels of melatonin in cerebral cortex and liver of rats under several conditions. The results show that melatonin levels in the…”
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Combination of melatonin and rapamycin for head and neck cancer therapy: Suppression of AKT/mTOR pathway activation, and activation of mitophagy and apoptosis via mitochondrial function regulation by Shen, Ying‐Qiang, Guerra‐Librero, Ana, Fernandez‐Gil, Beatriz I., Florido, Javier, García‐López, Sergio, Martinez‐Ruiz, Laura, Mendivil‐Perez, Miguel, Soto‐Mercado, Viviana, Acuña‐Castroviejo, Darío, Ortega‐Arellano, Hector, Carriel, Victor, Diaz‐Casado, María E., Reiter, Russel J., Rusanova, Iryna, Nieto, Ana, López, Luis C., Escames, Germaine

“…Head and neck squamous cell carcinoma (HNSCC) clearly involves activation of the Akt mammalian target of rapamycin (mTOR) signalling pathway. However, the…”
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The NLRP3 inflammasome: contributions to inflammation-related diseases by Chen, Ying, Ye, Xingyan, Escames, Germaine, Lei, Wangrui, Zhang, Xin, Li, Meng, Jing, Tong, Yao, Yu, Qiu, Zhenye, Wang, Zheng, Acuña-Castroviejo, Darío, Yang, Yang

“…The NOD-like receptor protein 3 (NLRP3) inflammasome is a protein complex that regulates innate immune responses by activating caspase-1 and the inflammatory…”
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The Zebrafish, an Outstanding Model for Biomedical Research in the Field of Melatonin and Human Diseases by Aranda-Martínez, Paula, Fernández-Martínez, José, Ramírez-Casas, Yolanda, Guerra-Librero, Ana, Rodríguez-Santana, César, Escames, Germaine, Acuña-Castroviejo, Darío

“…The zebrafish has become an excellent model for the study of human diseases because it offers many advantages over other vertebrate animal models. The pineal…”
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Same molecule but different expression: aging and sepsis trigger NLRP3 inflammasome activation, a target of melatonin by Volt, Huayqui, García, José A., Doerrier, Carolina, Díaz-Casado, María E., Guerra-Librero, Ana, López, Luis C., Escames, Germaine, Tresguerres, Jesús A., Acuña-Castroviejo, Darío

“…The connection between the innate immune system, clock genes, and mitochondrial bioenergetics was analyzed during aging and sepsis in mouse heart. Our results…”
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Melatonin drives apoptosis in head and neck cancer by increasing mitochondrial ROS generated via reverse electron transport by Florido, Javier, Martinez‐Ruiz, Laura, Rodriguez‐Santana, César, López‐Rodríguez, Alba, Hidalgo‐Gutiérrez, Agustín, Cottet‐Rousselle, Cécile, Lamarche, Frédéric, Schlattner, Uwe, Guerra‐Librero, Ana, Aranda‐Martínez, Paula, Acuña‐Castroviejo, Darío, López, Luis C., Escames, Germaine

“…The oncostatic effects of melatonin correlate with increased reactive oxygen species (ROS) levels, but how melatonin induces this ROS generation is unknown. In…”
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Melatonin blunts the mitochondrial/NLRP3 connection and protects against radiation-induced oral mucositis by Ortiz, Francisco, Acuña-Castroviejo, Darío, Doerrier, Carolina, Dayoub, José C., López, Luis C., Venegas, Carmen, García, José A., López, Ana, Volt, Huayqui, Luna-Sánchez, Marta, Escames, Germaine

“…Mucositis is a common and distressing side effect of chemotherapy or radiotherapy that has potentially severe consequences, and no treatment is available. The…”
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Melatonin enhances neural stem cell differentiation and engraftment by increasing mitochondrial function by Mendivil‐Perez, Miguel, Soto‐Mercado, Viviana, Guerra‐Librero, Ana, Fernandez‐Gil, Beatriz I., Florido, Javier, Shen, Ying‐Qiang, Tejada, Miguel A., Capilla‐Gonzalez, Vivian, Rusanova, Iryna, Garcia‐Verdugo, José M., Acuña‐Castroviejo, Darío, López, Luis Carlos, Velez‐Pardo, Carlos, Jimenez‐Del‐Rio, Marlene, Ferrer, José M., Escames, Germaine

“…Neural stem cells (NSCs) are regarded as a promising therapeutic approach to protecting and restoring damaged neurons in neurodegenerative diseases (NDs) such…”
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Melatonin protects rats from radiotherapy-induced small intestine toxicity by Fernández-Gil, Beatriz, Moneim, Ahmed E Abdel, Ortiz, Francisco, Shen, Ying-Qiang, Soto-Mercado, Viviana, Mendivil-Perez, Miguel, Guerra-Librero, Ana, Acuña-Castroviejo, Darío, Molina-Navarro, María M, García-Verdugo, José M, Sayed, Ramy K A, Florido, Javier, Luna, Juan D, López, Luis Carlos, Escames, Germaine

“…Radiotherapy-induced gut toxicity is among the most prevalent dose-limiting toxicities following radiotherapy. Prevention of radiation enteropathy requires…”
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Age and Chronodisruption in Mouse Heart: Effect of the NLRP3 Inflammasome and Melatonin Therapy by Fernández-Ortiz, Marisol, Sayed, Ramy K. A., Román-Montoya, Yolanda, de Lama, María Ángeles Rol, Fernández-Martínez, José, Ramírez-Casas, Yolanda, Florido-Ruiz, Javier, Rusanova, Iryna, Escames, Germaine, Acuña-Castroviejo, Darío

“…Age and age-dependent inflammation are two main risk factors for cardiovascular diseases. Aging can also affect clock gene-related impairments such as…”
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Melatonin mitigates mitochondrial malfunction by León, Josefa, Acuña-Castroviejo, Darío, Escames, Germane, Tan, Dun-Xian, Reiter, Russel J.

“…:  Melatonin, or N‐acetyl‐5‐methoxytryptamine, is a compound derived from tryptophan that is found in all organisms from unicells to vertebrates. This…”
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Analysis of the daily changes of melatonin receptors in the rat liver by Venegas, Carmen, García, José A., Doerrier, Carolina, Volt, Huayqui, Escames, Germaine, López, Luis C., Reiter, Russel J., Acuña-Castroviejo, Darío

“…Melatonin membrane (MT1 and MT2) and nuclear (RORα) receptors have been identified in several mammalian tissues, including the liver. The mechanisms regulating…”
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Melatonin rescues zebrafish embryos from the parkinsonian phenotype restoring the parkin/PINK1/DJ-1/MUL1 network by Díaz-Casado, María E., Lima, Elena, García, José A, Doerrier, Carolina, Aranda, Paula, Sayed, Ramy KA, Guerra-Librero, Ana, Escames, Germaine, López, Luis C, Acuña-Castroviejo, Darío

“…Multiple studies reporting mitochondrial impairment in Parkinson's disease (PD) involve knockout or knockdown models to inhibit the expression of…”
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CoQ deficiency causes disruption of mitochondrial sulfide oxidation, a new pathomechanism associated with this syndrome by Luna‐Sánchez, Marta, Hidalgo‐Gutiérrez, Agustín, Hildebrandt, Tatjana M, Chaves‐Serrano, Julio, Barriocanal‐Casado, Eliana, Santos‐Fandila, Ángela, Romero, Miguel, Sayed, Ramy KA, Duarte, Juan, Prokisch, Holger, Schuelke, Markus, Distelmaier, Felix, Escames, Germaine, Acuña‐Castroviejo, Darío, López, Luis C

“…Coenzyme Q (CoQ) is a key component of the mitochondrial respiratory chain, but it also has several other functions in the cellular metabolism. One of them is…”
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A review of the melatonin functions in zebrafish physiology by Lima-Cabello, Elena, Díaz-Casado, María E., Guerrero, Jose A., Otalora, Beatriz B., Escames, Germaine, López, Luis C., Reiter, Russel J., Acuña-Castroviejo, Darío

“…Melatonin is part of the evolutionary conserved highly functional network in vertebrates. It plays a central role in the adaptative behavior of the animal to…”
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Identification of morphological markers of sarcopenia at early stage of aging in skeletal muscle of mice by Sayed, Ramy K.A., de Leonardis, Erika Chacin, Guerrero-Martínez, José A., Rahim, Ibtissem, Mokhtar, Doaa M., Saleh, Abdelmohaimen M., Abdalla, Kamal E.H., Pozo, María J., Escames, Germaine, López, Luis C., Acuña-Castroviejo, Darío

“…The gastrocnemius muscle (GM) of young (3months) and aged (12months) female wild-type C57/BL6 mice was examined by light and electron microscopy, looking for…”
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The Melatonin Analog IQM316 May Induce Adult Hippocampal Neurogenesis and Preserve Recognition Memories in Mice by Figueiro-Silva, Joana, Antequera, Desireé, Pascual, Consuelo, de la Fuente Revenga, Mario, Volt, Huayqui, Acuña-Castroviejo, Darío, Rodríguez-Franco, María Isabel, Carro, Eva

“…Neurogenesis in the adult hippocampus is a unique process in neurobiology that requires functional integration of newly generated neurons, which may disrupt…”
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Identification of PIK3CG as a hub in septic myocardial injury using network pharmacology and weighted gene co‐expression network analysis by Liu, Qiong, Dong, Yushu, Escames, Germaine, Wu, Xue, Ren, Jun, Yang, Wenwen, Zhang, Shaofei, Zhu, Yanli, Tian, Ye, Acuña‐Castroviejo, Darío, Yang, Yang

“…Sepsis causes multiple organ injuries, among which the heart is one most severely damaged organ. Melatonin (MEL) alleviates septic myocardial injury, although…”
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Mitochondrial impairment and melatonin protection in parkinsonian mice do not depend of inducible or neuronal nitric oxide synthases by López, Ana, Ortiz, Francisco, Doerrier, Carolina, Venegas, Carmen, Fernández-Ortiz, Marisol, Aranda, Paula, Díaz-Casado, María E, Fernández-Gil, Beatriz, Barriocanal-Casado, Eliana, Escames, Germaine, López, Luis C, Acuña-Castroviejo, Darío

“…MPTP-mouse model constitutes a well-known model of neuroinflammation and mitochondrial failure occurring in Parkinson's disease (PD). Although it has been…”
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Attenuation of cardiac mitochondrial dysfunction by melatonin in septic mice by Escames, Germaine, López, Luis C., Ortiz, Francisco, López, Ana, García, José A., Ros, Eduardo, Acuña‐Castroviejo, Darío

“…The existence of an inducible mitochondrial nitric oxide synthase has been recently related to the nitrosative/oxidative damage and mitochondrial dysfunction…”
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