Search Results - "Acton, P. D."

Limbic selectivity of clozapine by Pilowsky, L S, Mulligan, R S, Acton, P D, Ell, P J, Costa, D C, Kerwin, R W

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Quantification of Serotonin Transporters in Nonhuman Primates Using [123I]ADAM and SPECT by Acton, Paul D, Choi, Seok-Rye, Hou, Catherine, Plossl, Karl, Kung, Hank F

“…We reported recently a highly selective radioligand, 2-([2-([dimethylamino]methyl)phenyl]thio)-5-[(123)I]iodophenylamine (ADAM), for SPECT imaging of serotonin…”
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Binding of [99mTc]TRODAT-1 to Dopamine Transporters in Patients with Parkinson's Disease and in Healthy Volunteers by Mozley, P. David, Schneider, Jay S, Acton, Paul D, Plossl, Karl, Stern, Matthew B, Siderowf, Andrew, Leopold, Norman A, Li, Pei Yong, Alavi, Abass, Kung, Hank F

“…[99mTc]TRODAT-1 is a radiolabeled tropane that binds dopamine transporters. The primary goal of this study was to determine whether its regional cerebral…”
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Striatal and extra-striatal D2/D3 dopamine receptor occupancy by quetiapine in vivo: [123I]-epidepride single photon emission tomography(SPET) study by STEPHENSON, C. M. E, BIGLIANI, V, JONES, H. M, MULLIGAN, R. S, ACTON, P. D, VISVIKIS, D, ELL, P. J, KERWIN, R. W, PILOWSKY, L. S

“…BackgroundSelective action at limbic cortical dopamine D2-like receptors could mediate atypical antipsychotic efficacy with few extrapyramidal…”
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Striatal and temporal cortical D2/D3 receptor occupancy by olanzapine and sertindole in vivo : a [123I]epidepride single photon emission tomography (SPET) study by BIGLIANI, V, MULLIGAN, R. S, ACTON, P. D, OHLSEN, R. I, PIKE, V. W, ELL, P. J, GACINOVIC, S, KERWIN, R. W, PILOWSKY, L. S

“…Previous work suggests clozapine preferentially targets limbic cortical dopamine systems, which could help account for its lack of extrapyramidal side effects…”
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Effects of Age on Dopamine Transporters in Healthy Humans by Mozley, P. David, Acton, Paul D, Barraclough, Eleathea D, Plossl, Karl, Gur, Ruben C, Alavi, Abass, Mathur, Ajit, Saffer, Janet, Kung, Hank F

“…99mTc-TRODAT-1 is a new radiopharmaceutical that selectively binds the dopamine transporters. This study characterized the effects of aging on its regional…”
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Logistic discriminant parametric mapping: a novel method for the pixel-based differential diagnosis of Parkinson's disease by Acton, P D, Mozley, P D, Kung, H F

“…Positron emission tomography (PET) and single-photon emission tomography (SPET) imaging of the dopaminergic system is a powerful tool for distinguishing groups…”
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Reduced levels of GABA-benzodiazepine receptor in alcohol dependency in the absence of grey matter atrophy by Lingford-Hughes, A R, Acton, P D, Gacinovic, S, Suckling, J, Busatto, G F, Boddington, S J, Bullmore, E, Woodruff, P W, Costa, D C, Pilowsky, L S, Ell, P J, Marshall, E J, Kerwin, R W

“…We tested the hypothesis that reduced levels of the GABA-benzodiazepine receptor occur in alcohol dependency using single photon emission tomography (SPET) and…”
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Characterization of [(123)I]IDAM as a novel single-photon emission tomography tracer for serotonin transporters by Kung, M P, Hou, C, Oya, S, Mu, M, Acton, P D, Kung, H F

“…Development of selective serotonin transporter (SERT) tracers for single-photon emission tomography (SPET) is important for studying the underlying…”
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PET imaging using gamma camera systems: a review by Jarritt, P H, Acton, P D

“…Optimized positron emission tomographs have begun to demonstrate an ever widening range of clinical applications for positron labelled pharmaceuticals. This…”
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Simplified reference region model for the kinetic analysis of [99mTc]TRODAT-1 binding to dopamine transporters in nonhuman primates using single-photon emission tomography by Acton, P D, Kushner, S A, Kung, M P, Mozley, P D, Plössl, K, Kung, H F

“…Accurate quantification of neuroreceptors requires full kinetic modeling of the dynamic single-photon emission tomography (SPET) or positron emission…”
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Imaging reporter genes for cell tracking with PET and SPECT by Acton, P D, Zhou, R

“…Transplantation of cells into damaged tissue has tremendous therapeutic potential in a number of disorders, such as Parkinson's disease and myocardial…”
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Automatic segmentation of dynamic neuroreceptor single-photon emission tomography images using fuzzy clustering by Acton, P D, Pilowsky, L S, Kung, H F, Ell, P J

“…The segmentation of medical images is one of the most important steps in the analysis and quantification of imaging data. However, partial volume artefacts…”
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Single-photon emission tomography imaging of serotonin transporters in the non-human primate brain with the selective radioligand [(123)I]IDAM by Acton, P D, Kung, M P, Mu, M, Plössl, K, Hou, C, Siciliano, M, Oya, S, Kung, H F

“…A new radioligand, 5-iodo-2-[[2-2-[(dimethylamino)methyl]phenyl]thio]benzyl alcohol ([(123)I]IDAM), has been developed for selective single-photon emission…”
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Feasibility of imaging photodynamic injury to tumours by high-resolution positron emission tomography by Moore, J V, Waller, M L, Zhao, S, Dodd, N J, Acton, P D, Jeavons, A P, Hastings, D L

“…One early effect of the treatment of tumours by the new modality photodynamic therapy (PDT) is a reduction in tumour glucose levels. We have employed the…”
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Single-photon emission tomography imaging of serotonin transporters in the nonhuman primate brain with [(123)I]ODAM by Acton, P D, Mu, M, Plössl, K, Hou, C, Siciliano, M, Zhuang, Z P, Oya, S, Choi, S R, Kung, H F

“…We have described previously a selective serotonin transporter (SERT) radioligand, [(123)I]IDAM. We now report a similarly potent, but more stable IDAM…”
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Statistical parametric mapping in functional neuroimaging: beyond PET and fMRI activation studies by Acton, P D, Friston, K J

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Levels of γ-Aminobutyric Acid-Benzodiazepine Receptors in Abstinent, Alcohol-Dependent Women: Preliminary Findings From an 123I-Iomazenil Single Photon Emission Tomography Study by Lingford-Hughes, A. R., Acton, P. D., Gacinovic, S., Boddington, S. J. A., Costa, D. C., Pilowsky, L. S., Ell, P. J., Marshall, E. J., Kerwin, R. W.

“…Background: Although alcohol dependence in women is an increasing problem, little is known about the effects of alcohol on the female brain. Evidence from a…”
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Diagnosis of Parkinsonian disorders using a channelized Hotelling observer model: Proof of principle by Bal, H., Bal, G., Acton, P. D.

“…Imaging dopamine transporters using PET and SPECT probes is a powerful technique for the early diagnosis of Parkinsonian disorders. In order to perform…”
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2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine (ADAM): an improved serotonin transporter ligand by Oya, Shunichi, Choi, Seok-Rye, Hou, Catherine, Mu, Mu, Kung, Mei-Ping, Acton, Paul D, Siciliano, Michael, Kung, Hank F

“…Serotonin transporters (SERT) are target-sites for commonly used antidepressants, such as fluoxetine, paroxetine, sertraline, and so on. Imaging of these sites…”
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