Search Results - "Acton, Oliver"
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Structural basis for broad coronavirus neutralization
Published in Nature structural & molecular biology (01-06-2021)“…Three highly pathogenic β-coronaviruses have crossed the animal-to-human species barrier in the past two decades: SARS-CoV, MERS-CoV and SARS-CoV-2. To…”
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Journal Article -
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Quadrivalent influenza nanoparticle vaccines induce broad protection
Published in Nature (London) (22-04-2021)“…Influenza vaccines that confer broad and durable protection against diverse viral strains would have a major effect on global health, as they would lessen the…”
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Journal Article -
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Platform-directed allostery and quaternary structure dynamics of SAMHD1 catalysis
Published in Nature communications (06-05-2024)“…SAMHD1 regulates cellular nucleotide homeostasis, controlling dNTP levels by catalysing their hydrolysis into 2’-deoxynucleosides and triphosphate. In…”
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Journal Article -
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Structure-based design of stabilized recombinant influenza neuraminidase tetramers
Published in Nature communications (05-04-2022)“…Influenza virus neuraminidase (NA) is a major antiviral drug target and has recently reemerged as a key target of antibody-mediated protective immunity. Here…”
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Journal Article -
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Mapping Neutralizing and Immunodominant Sites on the SARS-CoV-2 Spike Receptor-Binding Domain by Structure-Guided High-Resolution Serology
Published in Cell (12-11-2020)“…Analysis of the specificity and kinetics of neutralizing antibodies (nAbs) elicited by SARS-CoV-2 infection is crucial for understanding immune protection and…”
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Journal Article -
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Structural basis for Fullerene geometry in a human endogenous retrovirus capsid
Published in Nature communications (20-12-2019)“…The HML2 (HERV-K) group constitutes the most recently acquired family of human endogenous retroviruses, with many proviruses less than one million years old…”
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Structural analysis of retrovirus assembly and restriction factors by electron cryomicroscopy
Published 01-01-2019“…In order to better understand and combat retroviral infection, molecular structures of complexes involved in the life cycle are required. Two important areas…”
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Dissertation -
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Defining the conformation of human mincle that interacts with mycobacterial trehalose dimycolate
Published in Glycobiology (Oxford) (01-12-2014)“…Trehalose dimycolate, an unusual glycolipid in the outer membrane of Mycobacterium tuberculosis, stimulates macrophages by binding to the macrophage receptor…”
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Frequency Response Function Based Damage Identification for Aerospace Structures
Published 01-01-2015“…Structural health monitoring technologies continue to be pursued for aerospace structures in the interests of increased safety and, when combined with health…”
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Dissertation -
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Frequency Response Function Based Damage Identification for Aerospace Structures
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Dissertation