Search Results - "Acta pharmacologica Sinica"

Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19 by Huang, Yuan, Yang, Chan, Xu, Xin-feng, Xu, Wei, Liu, Shu-wen

“…Coronavirus disease 2019 is a newly emerging infectious disease currently spreading across the world. It is caused by a novel coronavirus, severe acute…”
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CB-Dock: a web server for cavity detection-guided protein–ligand blind docking by Liu, Yang, Grimm, Maximilian, Dai, Wen-tao, Hou, Mu-chun, Xiao, Zhi-Xiong, Cao, Yang

“…As the number of elucidated protein structures is rapidly increasing, the growing data call for methods to efficiently exploit the structural information for…”
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Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients by Su, Hai-xia, Yao, Sheng, Zhao, Wen-feng, Li, Min-jun, Liu, Jia, Shang, Wei-juan, Xie, Hang, Ke, Chang-qiang, Hu, Hang-chen, Gao, Mei-na, Yu, Kun-qian, Liu, Hong, Shen, Jing-shan, Tang, Wei, Zhang, Lei-ke, Xiao, Geng-fu, Ni, Li, Wang, Dao-wen, Zuo, Jian-ping, Jiang, Hua-liang, Bai, Fang, Wu, Yan, Ye, Yang, Xu, Ye-chun

“…Human infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19) and there is no cure currently…”
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Endothelial dysfunction in COVID-19: an overview of evidence, biomarkers, mechanisms and potential therapies by Xu, Suo-wen, Ilyas, Iqra, Weng, Jian-ping

“…The fight against coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection is still raging. However, the pathophysiology of acute and post-acute…”
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Engineering exosomes as refined biological nanoplatforms for drug delivery by Luan, Xin, Sansanaphongpricha, Kanokwan, Myers, Ila, Chen, Hongwei, Yuan, Hebao, Sun, Duxin

“…Exosomes, a subgroup of extracellular vesicles (EVs), have been recognized as important mediators of long distance intercellular communication and are involved…”
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Natural products: potential treatments for cisplatin-induced nephrotoxicity by Fang, Chun-yan, Lou, Da-yong, Zhou, Li-qin, Wang, Jin-cheng, Yang, Bo, He, Qiao-jun, Wang, Jia-jia, Weng, Qin-jie

“…Cisplatin is a clinically advanced and highly effective anticancer drug used in the treatment of a wide variety of malignancies, such as head and neck, lung,…”
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miRNAS in cardiovascular diseases: potential biomarkers, therapeutic targets and challenges by Zhou, Shan-shan, Jin, Jing-peng, Wang, Ji-qun, Zhang, Zhi-guo, Freedman, Jonathan H, Zheng, Yang, Cai, Lu

“…Cardiovascular diseases (CVD) are the leading cause of morbidity and mortality in the world. Although considerable progress has been made in the diagnosis,…”
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Artesunate synergizes with sorafenib to induce ferroptosis in hepatocellular carcinoma by Li, Zhong-jie, Dai, Hui-qi, Huang, Xiao-wei, Feng, Ji, Deng, Jing-huan, Wang, Zi-xuan, Yang, Xiao-mei, Liu, Yu-jia, Wu, Yong, Chen, Pan-hong, Shi, Huan, Wang, Ji-gang, Zhou, Jing, Lu, Guo-dong

“…Sorafenib is the first-line medication for advanced hepatocellular carcinoma (HCC), but it can only extend limited survival. It is imperative to find a…”
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Small molecule inhibitors targeting the PD-1/PD-L1 signaling pathway by Wu, Qian, Jiang, Li, Li, Si-cheng, He, Qiao-jun, Yang, Bo, Cao, Ji

“…Tumor cells form immune escape and subsequently obtain unlimited proliferation ability due to the abnormal immune surveillance mediated by immune checkpoints…”
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Drp1-dependent mitochondrial fission in cardiovascular disease by Jin, Jia-yu, Wei, Xiang-xiang, Zhi, Xiu-ling, Wang, Xin-hong, Meng, Dan

“…Mitochondria are highly dynamic organelles undergoing cycles of fusion and fission to modulate their morphology, distribution, and function, which are referred…”
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Salvia miltiorrhizaBurge (Danshen): a golden herbal medicine in cardiovascular therapeutics by Li, Zhuo-ming, Xu, Suo-wen, Liu, Pei-qing

“…Salvia miltiorrhiza Burge (Danshen) is an eminent medicinal herb that possesses broad cardiovascular and cerebrovascular protective actions and has been used…”
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Exosomes: new molecular targets of diseases by Samanta, Saheli, Rajasingh, Sheeja, Drosos, Nicholas, Zhou, Zhigang, Dawn, Buddhadeb, Rajasingh, Johnson

“…Extracellular vesicles (EVs) comprise apoptotic bodies, microvesicles and exosomes, and they perform as key regulators in cell-to-cell communication in normal…”
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Exosomal cargo-loading and synthetic exosome-mimics as potential therapeutic tools by Li, Song-pei, Lin, Zhong-xiao, Jiang, Xue-yan, Yu, Xi-yong

“…Exosomes are nano-sized vesicles that serve as mediators for intercellular communication through the delivery of cargo, including protein, lipids, nucleic…”
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Mitochondrial-derived damage-associated molecular patterns amplify neuroinflammation in neurodegenerative diseases by Lin, Miao-miao, Liu, Na, Qin, Zheng-hong, Wang, Yan

“…Both mitochondrial dysfunction and neuroinflammation are implicated in neurodegeneration and neurodegenerative diseases. Accumulating evidence shows multiple…”
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Zinc deficiency and cellular oxidative stress: prognostic implications in cardiovascular diseases by Choi, Sangyong, Liu, Xian, Pan, Zui

“…Zinc is an essential nutrient for human health and has anti-oxidative stress and anti-inflammatory functions. The association between zinc deficiency and the…”
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Hypoxia, HIF-1α, and COVID-19: from pathogenic factors to potential therapeutic targets by Serebrovska, Zoya O., Chong, Elisa Y., Serebrovska, Tetiana V., Tumanovska, Lesia V., Xi, Lei

“…The pandemic of coronavirus disease 2019 (COVID-19) and its pathogen, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have become the greatest…”
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Growth factors-based therapeutic strategies and their underlying signaling mechanisms for peripheral nerve regeneration by Li, Rui, Li, Duo-hui, Zhang, Hong-yu, Wang, Jian, Li, Xiao-kun, Xiao, Jian

“…Peripheral nerve injury (PNI), one of the most common concerns following trauma, can result in a significant loss of sensory or motor function. Restoration of…”
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Vascular endothelial dysfunction, a major mediator in diabetic cardiomyopathy by Knapp, Maura, Tu, Xin, Wu, Rongxue

“…Diabetes mellitus is currently a major public health problem. A common complication of diabetes is cardiac dysfunction, which is recognized as a microvascular…”
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Regulation of microglial activation in stroke by Zhao, Shou-cai, Ma, Ling-song, Chu, Zhao-hu, Xu, Heng, Wu, Wen-qian, Liu, Fudong

“…When ischemic stroke occurs, oxygen and energy depletion triggers a cascade of events, including inflammatory responses, glutamate excitotoxicity, oxidative…”
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Caspase-11/4 and gasdermin D-mediated pyroptosis contributes to podocyte injury in mouse diabetic nephropathy by Cheng, Qian, Pan, Jing, Zhou, Zhuan-li, Yin, Fan, Xie, Hong-yan, Chen, Pan-pan, Li, Jing-yao, Zheng, Pei-qing, Zhou, Li, Zhang, Wei, Liu, Jun, Lu, Li-min

“…Diabetic nephropathy (DN) is characterized by sterile inflammation with continuous injury and loss of renal inherent parenchyma cells. Podocyte is an essential…”
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