Search Results - "Acta pharmaceutica Sinica. B"

Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods by Wu, Canrong, Liu, Yang, Yang, Yueying, Zhang, Peng, Zhong, Wu, Wang, Yali, Wang, Qiqi, Xu, Yang, Li, Mingxue, Li, Xingzhou, Zheng, Mengzhu, Chen, Lixia, Li, Hua

“…SARS-CoV-2 has caused tens of thousands of infections and more than one thousand deaths. There are currently no registered therapies for treating coronavirus…”
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Why 90% of clinical drug development fails and how to improve it? by Sun, Duxin, Gao, Wei, Hu, Hongxiang, Zhou, Simon

“…Ninety percent of clinical drug development fails despite implementation of many successful strategies, which raised the question whether certain aspects in…”
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Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain reveals potential unique drug targeting sites by Kang, Sisi, Yang, Mei, Hong, Zhongsi, Zhang, Liping, Huang, Zhaoxia, Chen, Xiaoxue, He, Suhua, Zhou, Ziliang, Zhou, Zhechong, Chen, Qiuyue, Yan, Yan, Zhang, Changsheng, Shan, Hong, Chen, Shoudeng

“…The outbreak of coronavirus disease (COVID-19) caused by SARS-CoV-2 virus continually lead to worldwide human infections and deaths. Currently, there is no…”
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Gasdermin D in pyroptosis by Burdette, Brandon E., Esparza, Ashley N., Zhu, Hua, Wang, Shanzhi

“…Pyroptosis is the process of inflammatory cell death. The primary function of pyroptosis is to induce strong inflammatory responses that defend the host…”
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Recent progress in drug delivery by Li, Chong, Wang, Jiancheng, Wang, Yiguang, Gao, Huile, Wei, Gang, Huang, Yongzhuo, Yu, Haijun, Gan, Yong, Wang, Yongjun, Mei, Lin, Chen, Huabing, Hu, Haiyan, Zhang, Zhiping, Jin, Yiguang

“…Drug delivery systems (DDS) are defined as methods by which drugs are delivered to desired tissues, organs, cells and subcellular organs for drug release and…”
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The biology, function, and applications of exosomes in cancer by Liu, Jinyi, Ren, Liwen, Li, Sha, Li, Wan, Zheng, Xiangjin, Yang, Yihui, Fu, Weiqi, Yi, Jie, Wang, Jinhua, Du, Guanhua

“…Exosomes are cell-derived nanovesicles with diameters from 30 to 150 nm, released upon fusion of multivesicular bodies with the cell surface. They can…”
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Metabolic dysregulation and emerging therapeutical targets for hepatocellular carcinoma by Du, Danyu, Liu, Chan, Qin, Mengyao, Zhang, Xiao, Xi, Tao, Yuan, Shengtao, Hao, Haiping, Xiong, Jing

“…Hepatocellular carcinoma (HCC) is an aggressive human cancer with increasing incidence worldwide. Multiple efforts have been made to explore pharmaceutical…”
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Ferroptosis is essential for diabetic cardiomyopathy and is prevented by sulforaphane via AMPK/NRF2 pathways by Wang, Xiang, Chen, Xinxin, Zhou, Wenqian, Men, Hongbo, Bao, Terigen, Sun, Yike, Wang, Quanwei, Tan, Yi, Keller, Bradley B., Tong, Qian, Zheng, Yang, Cai, Lu

“…Herein, we define the role of ferroptosis in the pathogenesis of diabetic cardiomyopathy (DCM) by examining the expression of key regulators of ferroptosis in…”
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Metal-organic frameworks for advanced drug delivery by He, Siyu, Wu, Li, Li, Xue, Sun, Hongyu, Xiong, Ting, Liu, Jie, Huang, Chengxi, Xu, Huipeng, Sun, Huimin, Chen, Weidong, Gref, Ruxandra, Zhang, Jiwen

“…Metal-organic frameworks (MOFs), comprised of organic ligands and metal ions/metal clusters via coordinative bonds are highly porous, crystalline materials…”
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Red blood cell membrane-camouflaged nanoparticles: a novel drug delivery system for antitumor application by Xia, Qing, Zhang, Yongtai, Li, Zhe, Hou, Xuefeng, Feng, Nianping

“…Erythrocytes (red blood cells, RBCs) are the most abundant circulating cells in the blood and have been widely used in drug delivery systems (DDS) because of…”
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New opportunities and challenges of natural products research: When target identification meets single-cell multiomics by Zhu, Yuyu, Ouyang, Zijun, Du, Haojie, Wang, Meijing, Wang, Jiaojiao, Sun, Haiyan, Kong, Lingdong, Xu, Qiang, Ma, Hongyue, Sun, Yang

“…Natural products, and especially the active ingredients found in traditional Chinese medicine (TCM), have a thousand-year-long history of clinical use and a…”
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Adapting liposomes for oral drug delivery by He, Haisheng, Lu, Yi, Qi, Jianping, Zhu, Quangang, Chen, Zhongjian, Wu, Wei

“…Liposomes mimic natural cell membranes and have long been investigated as drug carriers due to excellent entrapment capacity, biocompatibility and safety…”
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Current trends in drug metabolism and pharmacokinetics by Li, Yuhua, Meng, Qiang, Yang, Mengbi, Liu, Dongyang, Hou, Xiangyu, Tang, Lan, Wang, Xin, Lyu, Yuanfeng, Chen, Xiaoyan, Liu, Kexin, Yu, Ai-Ming, Zuo, Zhong, Bi, Huichang

“…Pharmacokinetics (PK) is the study of the absorption, distribution, metabolism, and excretion (ADME) processes of a drug. Understanding PK properties is…”
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Mesoporous silica nanoparticles for drug and gene delivery by Zhou, Yixian, Quan, Guilan, Wu, Qiaoli, Zhang, Xiaoxu, Niu, Boyi, Wu, Biyuan, Huang, Ying, Pan, Xin, Wu, Chuanbin

“…Mesoporous silica nanoparticles (MSNs) are attracting increasing interest for potential biomedical applications. With tailored mesoporous structure, huge…”
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Mitochondrial quality control mechanisms as molecular targets in cardiac ischemia–reperfusion injury by Wang, Jin, Zhou, Hao

“…Mitochondrial damage is a critical contributor to cardiac ischemia/reperfusion (I/R) injury. Mitochondrial quality control (MQC) mechanisms, a series of…”
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Pharmaceutical amorphous solid dispersion: A review of manufacturing strategies by Bhujbal, Sonal V., Mitra, Biplob, Jain, Uday, Gong, Yuchuan, Agrawal, Anjali, Karki, Shyam, Taylor, Lynne S., Kumar, Sumit, (Tony) Zhou, Qi

“…Amorphous solid dispersions (ASDs) are popular for enhancing the solubility and bioavailability of poorly water-soluble drugs. Various approaches have been…”
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Crystal structure of SARS-CoV-2 papain-like protease by Gao, Xiaopan, Qin, Bo, Chen, Pu, Zhu, Kaixiang, Hou, Pengjiao, Wojdyla, Justyna Aleksandra, Wang, Meitian, Cui, Sheng

“…The pandemic of coronavirus disease 2019 (COVID-19) is changing the world like never before. This crisis is unlikely contained in the absence of effective…”
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The role of tumor-associated macrophages (TAMs) in tumor progression and relevant advance in targeted therapy by Yang, Qiyao, Guo, Ningning, Zhou, Yi, Chen, Jiejian, Wei, Qichun, Han, Min

“…Macrophages have a leading position in the tumor microenvironment (TME) which paves the way to carcinogenesis. Initially, monocytes and macrophages are…”
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An updated overview on the development of new photosensitizers for anticancer photodynamic therapy by Zhang, Juan, Jiang, Chengshi, Figueiró Longo, João Paulo, Azevedo, Ricardo Bentes, Zhang, Hua, Muehlmann, Luis Alexandre

“…Photodynamic therapy (PDT), based on the photoactivation of photosensitizers (PSs), has become a well-studied therapy for cancer. Photofrin®, belonging to the…”
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Evolution of blood–brain barrier in brain diseases and related systemic nanoscale brain-targeting drug delivery strategies by Han, Liang, Jiang, Chen

“…Blood–brain barrier (BBB) strictly controls matter exchange between blood and brain, and severely limits brain penetration of systemically administered drugs,…”
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