Search Results - "Acta neuropathologica"

Plasma p-tau231: a new biomarker for incipient Alzheimer’s disease pathology by Ashton, Nicholas J., Pascoal, Tharick A., Karikari, Thomas K., Benedet, Andréa L., Lantero-Rodriguez, Juan, Brinkmalm, Gunnar, Snellman, Anniina, Schöll, Michael, Troakes, Claire, Hye, Abdul, Gauthier, Serge, Vanmechelen, Eugeen, Zetterberg, Henrik, Rosa-Neto, Pedro, Blennow, Kaj

“…The quantification of phosphorylated tau in biofluids, either cerebrospinal fluid (CSF) or plasma, has shown great promise in detecting Alzheimer’s disease…”
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Neuropathology of COVID-19: a spectrum of vascular and acute disseminated encephalomyelitis (ADEM)-like pathology by Reichard, R. Ross, Kashani, Kianoush B., Boire, Nicholas A., Constantopoulos, Eleni, Guo, Yong, Lucchinetti, Claudia F.

“…We report the neuropathological findings of a patient who died from complications of COVID-19. The decedent was initially hospitalized for surgical management…”
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The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary by Louis, David N., Perry, Arie, Reifenberger, Guido, von Deimling, Andreas, Figarella-Branger, Dominique, Cavenee, Webster K., Ohgaki, Hiroko, Wiestler, Otmar D., Kleihues, Paul, Ellison, David W.

“…The 2016 World Health Organization Classification of Tumors of the Central Nervous System is both a conceptual and practical advance over its 2007 predecessor…”
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cIMPACT-NOW update 3: recommended diagnostic criteria for “Diffuse astrocytic glioma, IDH-wildtype, with molecular features of glioblastoma, WHO grade IV” by Brat, Daniel J., Aldape, Kenneth, Colman, Howard, Holland, Eric C., Louis, David N., Jenkins, Robert B., Kleinschmidt-DeMasters, B. K., Perry, Arie, Reifenberger, Guido, Stupp, Roger, von Deimling, Andreas, Weller, Michael

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cIMPACT-NOW update 5: recommended grading criteria and terminologies for IDH-mutant astrocytomas by Brat, Daniel J., Aldape, Kenneth, Colman, Howard, Figrarella-Branger, Dominique, Fuller, Gregory N., Giannini, Caterina, Holland, Eric C., Jenkins, Robert B., Kleinschmidt-DeMasters, Bette, Komori, Takashi, Kros, Johan M., Louis, David N., McLean, Catriona, Perry, Arie, Reifenberger, Guido, Sarkar, Chitra, Stupp, Roger, van den Bent, Martin J., von Deimling, Andreas, Weller, Michael

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Functional morphology of the blood–brain barrier in health and disease by Liebner, Stefan, Dijkhuizen, Rick M., Reiss, Yvonne, Plate, Karl H., Agalliu, Dritan, Constantin, Gabriela

“…The adult quiescent blood–brain barrier (BBB), a structure organised by endothelial cells through interactions with pericytes, astrocytes, neurons and…”
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Neurotoxicity of pesticides by Richardson, Jason R., Fitsanakis, Vanessa, Westerink, Remco H. S., Kanthasamy, Anumantha G.

“…Pesticides are unique environmental contaminants that are specifically introduced into the environment to control pests, often by killing them. Although…”
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Distribution patterns of tau pathology in progressive supranuclear palsy by Kovacs, Gabor G., Lukic, Milica Jecmenica, Irwin, David J., Arzberger, Thomas, Respondek, Gesine, Lee, Edward B., Coughlin, David, Giese, Armin, Grossman, Murray, Kurz, Carolin, McMillan, Corey T., Gelpi, Ellen, Compta, Yaroslau, van Swieten, John C., Laat, Laura Donker, Troakes, Claire, Al-Sarraj, Safa, Robinson, John L., Roeber, Sigrun, Xie, Sharon X., Lee, Virginia M.- Y., Trojanowski, John Q., Höglinger, Günter U.

“…Progressive supranuclear palsy (PSP) is a 4R-tauopathy predominated by subcortical pathology in neurons, astrocytes, and oligodendroglia associated with…”
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Current state of Alzheimer’s fluid biomarkers by Molinuevo, José Luis, Ayton, Scott, Batrla, Richard, Bednar, Martin M., Bittner, Tobias, Cummings, Jeffrey, Fagan, Anne M., Hampel, Harald, Mielke, Michelle M., Mikulskis, Alvydas, O’Bryant, Sid, Scheltens, Philip, Sevigny, Jeffrey, Shaw, Leslie M., Soares, Holly D., Tong, Gary, Trojanowski, John Q., Zetterberg, Henrik, Blennow, Kaj

“…Alzheimer’s disease (AD) is a progressive neurodegenerative disease with a complex and heterogeneous pathophysiology. The number of people living with AD is…”
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The physiological roles of tau and Aβ: implications for Alzheimer’s disease pathology and therapeutics by Kent, Sarah A., Spires-Jones, Tara L., Durrant, Claire S.

“…Tau and amyloid beta (Aβ) are the prime suspects for driving pathology in Alzheimer’s disease (AD) and, as such, have become the focus of therapeutic…”
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Post-stroke inflammation—target or tool for therapy? by Lambertsen, Kate Lykke, Finsen, Bente, Clausen, Bettina Hjelm

“…Inflammation is currently considered a prime target for the development of new stroke therapies. In the acute phase of ischemic stroke, microglia are activated…”
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Roles of tau protein in health and disease by Guo, Tong, Noble, Wendy, Hanger, Diane P.

“…Tau is well established as a microtubule-associated protein in neurons. However, under pathological conditions, aberrant assembly of tau into insoluble…”
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Ultrasensitive RT-QuIC assay with high sensitivity and specificity for Lewy body-associated synucleinopathies by Rossi, Marcello, Candelise, Niccolò, Baiardi, Simone, Capellari, Sabina, Giannini, Giulia, Orrù, Christina D., Antelmi, Elena, Mammana, Angela, Hughson, Andrew G., Calandra-Buonaura, Giovanna, Ladogana, Anna, Plazzi, Giuseppe, Cortelli, Pietro, Caughey, Byron, Parchi, Piero

“…The clinical diagnosis of synucleinopathies, including Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA), is…”
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Plasma p-tau181 accurately predicts Alzheimer’s disease pathology at least 8 years prior to post-mortem and improves the clinical characterisation of cognitive decline by Lantero Rodriguez, Juan, Karikari, Thomas K., Suárez-Calvet, Marc, Troakes, Claire, King, Andrew, Emersic, Andreja, Aarsland, Dag, Hye, Abdul, Zetterberg, Henrik, Blennow, Kaj, Ashton, Nicholas J.

“…The neuropathological confirmation of amyloid-β (Aβ) plaques and tau neurofibrillary tangles (NFT) remains the gold standard for a definitive diagnosis of…”
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The role of brain barriers in fluid movement in the CNS: is there a ‘glymphatic’ system? by Abbott, N. Joan, Pizzo, Michelle E., Preston, Jane E., Janigro, Damir, Thorne, Robert G.

“…Brain fluids are rigidly regulated to provide stable environments for neuronal function, e.g., low K + , Ca 2+ , and protein to optimise signalling and…”
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Distinct amyloid-β and tau-associated microglia profiles in Alzheimer’s disease by Gerrits, Emma, Brouwer, Nieske, Kooistra, Susanne M., Woodbury, Maya E., Vermeiren, Yannick, Lambourne, Mirjam, Mulder, Jan, Kummer, Markus, Möller, Thomas, Biber, Knut, Dunnen, Wilfred F. A. den, De Deyn, Peter P., Eggen, Bart J. L., Boddeke, Erik W. G. M.

“…Alzheimer’s disease (AD) is the most prevalent form of dementia and is characterized by abnormal extracellular aggregates of amyloid-β and intraneuronal…”
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Practical implementation of DNA methylation and copy-number-based CNS tumor diagnostics: the Heidelberg experience by Capper, David, Stichel, Damian, Sahm, Felix, Jones, David T. W., Schrimpf, Daniel, Sill, Martin, Schmid, Simone, Hovestadt, Volker, Reuss, David E., Koelsche, Christian, Reinhardt, Annekathrin, Wefers, Annika K., Huang, Kristin, Sievers, Philipp, Ebrahimi, Azadeh, Schöler, Anne, Teichmann, Daniel, Koch, Arend, Hänggi, Daniel, Unterberg, Andreas, Platten, Michael, Wick, Wolfgang, Witt, Olaf, Milde, Till, Korshunov, Andrey, Pfister, Stefan M., von Deimling, Andreas

“…Recently, we described a machine learning approach for classification of central nervous system tumors based on the analysis of genome-wide DNA methylation…”
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The pathology of central nervous system inflammatory demyelinating disease accompanying myelin oligodendrocyte glycoprotein autoantibody by Höftberger, Romana, Guo, Yong, Flanagan, Eoin P., Lopez-Chiriboga, A. Sebastian, Endmayr, Verena, Hochmeister, Sonja, Joldic, Damir, Pittock, Sean J., Tillema, Jan Mendelt, Gorman, Mark, Lassmann, Hans, Lucchinetti, Claudia F.

“…We sought to define the pathological features of myelin oligodendrocyte glycoprotein (MOG) antibody associated disorders (MOGAD) in an archival autopsy/biopsy…”
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TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis by Cignarella, Francesca, Filipello, Fabia, Bollman, Bryan, Cantoni, Claudia, Locca, Alberto, Mikesell, Robert, Manis, Melissa, Ibrahim, Adiljan, Deng, Li, Benitez, Bruno A., Cruchaga, Carlos, Licastro, Danilo, Mihindukulasuriya, Kathie, Harari, Oscar, Buckland, Michael, Holtzman, David M., Rosenthal, Arnon, Schwabe, Tina, Tassi, Ilaria, Piccio, Laura

“…Multiple sclerosis (MS) is an inflammatory, demyelinating, and neurodegenerative disease of the central nervous system (CNS) triggered by autoimmune…”
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Aggregated Tau activates NLRP3–ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded Tau pathology in vivo by Stancu, Ilie-Cosmin, Cremers, Niels, Vanrusselt, Hannah, Couturier, Julien, Vanoosthuyse, Alexandre, Kessels, Sofie, Lodder, Chritica, Brône, Bert, Huaux, François, Octave, Jean-Noël, Terwel, Dick, Dewachter, Ilse

“…Brains of Alzheimer’s disease patients are characterized by the presence of amyloid plaques and neurofibrillary tangles, both invariably associated with…”
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