Search Results - "Ackley, D."

Bright lights, big synapses: fluorescent proteins let neurons shine by Ackley, Brian D

“…The availability of fluorescent proteins to visualize neurons and synapses has revolutionized our understanding of these key structures in brains. Here, I will…”
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Wild-type Caenorhabditis elegans isolates exhibit distinct gene expression profiles in response to microbial infection by Lansdon, Patrick, Carlson, Maci, Ackley, Brian D

“…The soil-dwelling nematode Caenorhabditis elegans serves as a model system to study innate immunity against microbial pathogens. C. elegans have been collected…”
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The Afterglow and Kilonova of the Short GRB 160821B by Troja, E., Castro-Tirado, A. J., Gonzalez, J Becerra, Hu, Y., Ryan, G. S., Cenko, S. B., Ricci, R., Novara, G., Sanchez-Ramirez, R., Acosta-Pulido, J. A., Ackley, K. D., Garcıa, M. D. Caballero, Eikenberry, S. S., Guziy, S., Jeong, S., Lien, A. Y., Marquez, I., Pandey, S. B., Park, I. H., Sakamoto, T., Tello, J. C., Sokolov, I. V., Tiengo, A., Valeev, A. F., Zhang, B. B., Veilleux, S.

“…GRB 160821B is a short duration gamma-ray burst (GRB) detected and localized by the Neil Gehrels Swift Observatory in the outskirts of a spiral galaxy at z =…”
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Wnt‐signaling and planar cell polarity genes regulate axon guidance along the anteroposterior axis in C. elegans by Ackley, Brian D.

“…ABSTRACT During the development of the nervous system, neurons encounter signals that inform their outgrowth and polarization. Understanding how these signals…”
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Optical trapping of sub-millimeter sized particles and microorganisms by Lialys, Laurynas, Lialys, Justinas, Salandrino, Alessandro, Ackley, Brian D., Fardad, Shima

“…While optical tweezers (OT) are mostly used for confining smaller size particles, the counter-propagating (CP) dual-beam traps have been a versatile method for…”
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Vitamin B12 Regulates Glial Migration and Synapse Formation through Isoform-Specific Control of PTP-3/LAR PRTP Expression by Zhang, Albert, Ackley, Brian D., Yan, Dong

“…Vitamin B12 is known to play critical roles during the development and aging of the brain, and vitamin B12 deficiency has been linked to neurodevelopmental and…”
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Familial Alzheimer mutations stabilize synaptotoxic γ-secretase-substrate complexes by Devkota, Sujan, Zhou, Rui, Nagarajan, Vaishnavi, Maesako, Masato, Do, Hung, Noorani, Arshad, Overmeyer, Caitlin, Bhattarai, Sanjay, Douglas, Justin T., Saraf, Anita, Miao, Yinglong, Ackley, Brian D., Shi, Yigong, Wolfe, Michael S.

“…Mutations that cause familial Alzheimer’s disease (FAD) are found in amyloid precursor protein (APP) and presenilin, the catalytic component of γ-secretase,…”
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Distinct roles for two Caenorhabditis elegans acid-sensing ion channels in an ultradian clock by Kaulich, Eva, Carroll, Trae, Ackley, Brian D, Tang, Yi-Quan, Hardege, Iris, Nehrke, Keith, Schafer, William R, Walker, Denise S

“…Biological clocks are fundamental to an organism's health, controlling periodicity of behaviour and metabolism. Here, we identify two acid-sensing ion…”
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The C. elegans CHP1 homolog, pbo-1, functions in innate immunity by regulating the pH of the intestinal lumen by Benomar, Saida, Lansdon, Patrick, Bender, Aaron M, Peterson, Blake R, Chandler, Josephine R, Ackley, Brian D

“…Caenorhabditis elegans are soil-dwelling nematodes and models for understanding innate immunity and infection. Previously, we developed a novel fluorescent dye…”
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Advances in ET-based landscape irrigation management by Snyder, R.L., Pedras, C., Montazar, A., Henry, J.M., Ackley, D.

“…•Techniques to determine landscape ET are compatible and useful in agriculture.•Surface renewal permits ET estimation in locations with less fetch.•The ratio…”
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Reevaluating safety pharmacology respiratory studies within the ICH S7A core battery: A multi-company evaluation of preclinical utility and clinical translation by Friedrichs, G.S., Abernathy, M.M., Ackley, D., Clark, M., DaSilva, J.K., Foley, C.M., Greiter-Wilke, A., Henderson, K.A, Kremer, J.J., Morimoto, B.H., Paglialunga, S., Pugsley, M.K., Regan, C.P., Rossman, E.I., Segretti, J.A., Traebert, M., Vargas, H.M., Wisialowski, T.A.

“…Optimization of ICH safety guideline studies for inclusion into regulatory submissions is critical for resource conservation, animal use reduction, and…”
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Age-dependent accumulation of tau aggregation in Caenorhabditis elegans by Aquino Nunez, Wendy, Combs, Benjamin, Gamblin, T Chris, Ackley, Brian D

“…Aging is the primary risk factor for Alzheimer's disease (AD) and related disorders (ADRDs). Tau aggregation is a hallmark of AD and other tauopathies. Even in…”
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High strength, acid‐resistant composites from canola, sunflower, or linseed oils: Influence of triglyceride unsaturation on material properties by Lopez, Claudia V., Karunarathna, Menisha S., Lauer, Moira K., Maladeniya, Charini P., Thiounn, Timmy, Ackley, Edward D., Smith, Rhett C.

“…Here are reported composites made by crosslinking unsaturated units in canola, sunflower, or linseed oil with sulfur to yield CanS, SunS, and LinS,…”
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C. elegans RPM-1 Regulates Axon Termination and Synaptogenesis through the Rab GEF GLO-4 and the Rab GTPase GLO-1 by Grill, Brock, Bienvenut, Willy V., Brown, Heather M., Ackley, Brian D., Quadroni, Manfredo, Jin, Yishi

“…C. elegans RPM-1 (for Regulator of Presynaptic Morphology) is a member of a conserved protein family that includes Drosophila Highwire and mammalian Pam and…”
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Hydrophobic analogues of rhodamine B and rhodamine 101: potent fluorescent probes of mitochondria in living C. elegans by Mottram, Laurie F, Forbes, Safiyyah, Ackley, Brian D, Peterson, Blake R

“…Mitochondria undergo dynamic fusion and fission events that affect the structure and function of these critical energy-producing cellular organelles. Defects…”
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The Immunoglobulin Superfamily Members syg-2 and syg-1 Regulate Neurite Development in C. elegans by Tucker, Dana K, Adams, Chloe S, Prasad, Gauri, Ackley, Brian D

“…Neurons form elaborate networks by guiding axons and dendrites to appropriate destinations. Neurites require information about the relative body axes during…”
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The Hox Gene egl-5 Acts as a Terminal Selector for VD13 Development via Wnt Signaling by Kurland, Meagan, O'Meara, Bryn, Tucker, Dana K, Ackley, Brian D

“…Nervous systems are comprised of diverse cell types that differ functionally and morphologically. During development, extrinsic signals, e.g., growth factors,…”
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Tomosyn inhibits synaptic vesicle priming in Caenorhabditis elegans by Gracheva, Elena O, Burdina, Anna O, Holgado, Andrea M, Berthelot-Grosjean, Martine, Ackley, Brian D, Hadwiger, Gayla, Nonet, Michael L, Weimer, Robby M, Richmond, Janet E

“…Caenorhabditis elegans TOM-1 is orthologous to vertebrate tomosyn, a cytosolic syntaxin-binding protein implicated in the modulation of both constitutive and…”
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A Synthetic Lethal Screen Identifies a Role for Lin-44/Wnt in C. elegans Embryogenesis by Hartin, Samantha N, Hudson, Martin L, Yingling, Curtis, Ackley, Brian D

“…The C. elegans proteins PTP-3/LAR-RPTP and SDN-1/Syndecan are conserved cell adhesion molecules. Loss-of-function (LOF) mutations in either ptp-3 or sdn-1…”
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The Caenorhabditis elegans voltage-gated calcium channel subunits UNC-2 and UNC-36 and the calcium-dependent kinase UNC-43/CaMKII regulate neuromuscular junction morphology by Caylor, Raymond C, Jin, Yishi, Ackley, Brian D

“…The conserved Caenorhabditis elegans proteins NID-1/nidogen and PTP-3A/LAR-RPTP function to efficiently localize the presynaptic scaffold protein…”
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