Blood group AB increases risk for surgical necrotizing enterocolitis and focal intestinal perforation in preterm infants with very low birth weight

Blood group AB increases risk for surgical necrotizing enterocolitis and focal intestinal perforation in preterm infants with very low birth weight

Necrotizing enterocolitis (NEC) and focal intestinal perforation (FIP) are two of the most common emergencies of the gastrointestinal tract in preterm infants with very low birth weight (VLBW, birth weight < 1500 g). Identification of risk factors among these children is crucial for earlier diagn...

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Bibliographic Details
Published in:Scientific reports Vol. 11; no. 1; p. 13777
Main Authors: Martynov, I., Göpel, W., Rausch, T. K., Härtel, C., Franke, A., Franz, A. R., Viemann, D., Thome, U. H., Lacher, M., Ackermann, B. W.
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 02-07-2021
Nature Publishing Group
Nature Portfolio
Subjects:
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692/308/3187
ABO system
Birth weight
Blood group AB
Blood groups
Enterocolitis
Gastrointestinal diseases
Gastrointestinal tract
Humanities and Social Sciences
Infants
Intestine
Low birth weight
multidisciplinary
Necrosis
Necrotizing enterocolitis
Neonates
Newborn babies
Population studies
Premature babies
Risk factors
Science
Science (multidisciplinary)
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Summary:Necrotizing enterocolitis (NEC) and focal intestinal perforation (FIP) are two of the most common emergencies of the gastrointestinal tract in preterm infants with very low birth weight (VLBW, birth weight < 1500 g). Identification of risk factors among these children is crucial for earlier diagnosis and prompt intervention. In this study, we investigated a relationship between ABO blood groups and the risk for surgical NEC/FIP. We genotyped the ABO locus (rs8176746 and rs8176719) in VLBW infants enrolled in a prospective, population-based cohort study of the German Neonatal Network (GNN). Of the 10,257 VLBW infants, 441 (4.3%) had surgical NEC/FIP. In univariate analyses, the blood group AB was more prevalent in VLBW infants with surgical NEC/FIP compared to non-AB blood groups (OR 1.51, 95% CI 1.07–2.13, p = 0.017; absolute risk difference 2.01%, 95% CI 0.06–3.96%). The association between blood group AB and surgical NEC/FIP was observed in a multivariable logistic regression model (OR of 1.58, 95% CI 1.10–2.26, p = 0.013) as well. In summary, our study suggests that the risk of surgical NEC and FIP is higher in patients with blood group AB and lower in those having non-AB blood groups.
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-93195-8