Search Results - "Ackerman, Steven J."

Contributions of Eosinophils to Human Health and Disease by Klion, Amy D, Ackerman, Steven J, Bochner, Bruce S

“…The human eosinophil has long been thought to favorably influence innate mucosal immunity but at times has also been incriminated in disease pathophysiology…”
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Eosinophils in Health and Disease: A State-of-the-Art Review by Wechsler, Michael E., Munitz, Ariel, Ackerman, Steven J., Drake, Matthew G., Jackson, David J., Wardlaw, Andrew J., Dougan, Stephanie K., Berdnikovs, Sergejs, Schleich, Florence, Matucci, Andrea, Chanez, Pascal, Prazma, Charlene M., Howarth, Peter, Weller, Peter F., Merkel, Peter A.

“…Eosinophils play a homeostatic role in the body’s immune responses. These cells are involved in combating some parasitic, bacterial, and viral infections and…”
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Recruited alveolar macrophages, in response to airway epithelial-derived monocyte chemoattractant protein 1/CCl2, regulate airway inflammation and remodeling in allergic asthma by Lee, Yong Gyu, Jeong, Jong Jin, Nyenhuis, Sharmilee, Berdyshev, Evgeny, Chung, Sangwoon, Ranjan, Ravi, Karpurapu, Manjula, Deng, Jing, Qian, Feng, Kelly, Elizabeth A B, Jarjour, Nizar N, Ackerman, Steven J, Natarajan, Viswanathan, Christman, John W, Park, Gye Young

“…Although alveolar macrophages (AMs) from patients with asthma are known to be functionally different from those of healthy individuals, the mechanism by which…”
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Novel peptide nanoparticle–biased antagonist of CCR3 blocks eosinophil recruitment and airway hyperresponsiveness by Grozdanovic, Milica, Laffey, Kimberly G., Abdelkarim, Hazem, Hitchinson, Ben, Harijith, Anantha, Moon, Hyung-Geon, Park, Gye Young, Rousslang, Lee K., Masterson, Joanne C., Furuta, Glenn T., Tarasova, Nadya I., Gaponenko, Vadim, Ackerman, Steven J.

“…Chemokine signaling through CCR3 is a key regulatory pathway for eosinophil recruitment into tissues associated with allergic inflammation and asthma. To date,…”
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Noninvasive biomarkers identify eosinophilic esophagitis: A prospective longitudinal study in children by Wechsler, Joshua B., Ackerman, Steven J., Chehade, Mirna, Amsden, Katie, Riffle, Mary E., Wang, Ming‐Yu, Du, Jian, Kleinjan, Matt L., Alumkal, Preeth, Gray, Elizabeth, Kim, Kwang‐Youn A., Wershil, Barry K., Kagalwalla, Amir F.

“…ABSTRACT Background Esophageal histology is critical for diagnosis and surveillance of disease activity in eosinophilic esophagitis (EoE). A validated…”
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Airway Epithelial Cell-Derived Colony Stimulating Factor-1 Promotes Allergen Sensitization by Moon, Hyung-Geun, Kim, Seung-jae, Jeong, Jong Jin, Han, Seon-Sook, Jarjour, Nizar N., Lee, Hyun, Abboud-Werner, Sherry L., Chung, Sangwoon, Choi, Hak Soo, Natarajan, Viswanathan, Ackerman, Steven J., Christman, John W., Park, Gye Young

“…Airway epithelial cells (AECs) secrete innate immune cytokines that regulate adaptive immune effector cells. In allergen-sensitized humans and mice, the airway…”
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CCAAT/Enhancer-Binding Protein ε27 Antagonism of GATA-1 Transcriptional Activity in the Eosinophil Is Mediated by a Unique N-Terminal Repression Domain, Is Independent of Sumoylation and Does Not Require DNA Binding by Stankiewicz, Monika J., Du, Jian, Martinico, Dominick, Ackerman, Steven J.

“…CCAAT/enhancer binding protein epsilon (C/EBPε) is required for eosinophil differentiation, lineage-specific gene transcription, and expression of C/EBPε32 and…”
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Esophageal microbiome in eosinophilic esophagitis by Harris, J Kirk, Fang, Rui, Wagner, Brandie D, Choe, Ha Na, Kelly, Caleb J, Schroeder, Shauna, Moore, Wendy, Stevens, Mark J, Yeckes, Alyson, Amsden, Katie, Kagalwalla, Amir F, Zalewski, Angelika, Hirano, Ikuo, Gonsalves, Nirmala, Henry, Lauren N, Masterson, Joanne C, Robertson, Charles E, Leung, Donald Y, Pace, Norman R, Ackerman, Steven J, Furuta, Glenn T, Fillon, Sophie A

“…The microbiome has been implicated in the pathogenesis of a number of allergic and inflammatory diseases. The mucosa affected by eosinophilic esophagitis (EoE)…”
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Eosinophilic esophagitis: Epithelial mesenchymal transition contributes to esophageal remodeling and reverses with treatment by Kagalwalla, Amir F., MD, Akhtar, Noorain, MD, Woodruff, Samantha A., MD, Rea, Bryan A., BA, Masterson, Joanne C., PhD, Mukkada, Vincent, MD, Parashette, Kalyan R., MD, Du, Jian, MD, Fillon, Sophie, PhD, Protheroe, Cheryl A., BA, Lee, James J., PhD, Amsden, Katie, BS, Melin-Aldana, Hector, MD, Capocelli, Kelley E., MD, Furuta, Glenn T., MD, Ackerman, Steven J., PhD

“…Background Mechanisms underlying esophageal remodeling with subepithelial fibrosis in subjects with eosinophilic esophagitis (EoE) have not been delineated…”
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Novel device to sample the esophageal microbiome--the esophageal string test by Fillon, Sophie A, Harris, J Kirk, Wagner, Brandie D, Kelly, Caleb J, Stevens, Mark J, Moore, Wendy, Fang, Rui, Schroeder, Shauna, Masterson, Joanne C, Robertson, Charles E, Pace, Norman R, Ackerman, Steven J, Furuta, Glenn T

“…A growing number of studies implicate the microbiome in the pathogenesis of intestinal inflammation. Previous work has shown that adults with esophagitis…”
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Transcriptional Regulation of the Human IL5RA Gene through Alternative Promoter Usage during Eosinophil Development by Laffey, Kimberly G., Du, Jian, Schrum, Adam G., Ackerman, Steven J.

“…Regulation of the IL-5 receptor alpha (IL5RA) gene is complicated, with two known promoters (P1 and P2) driving transcription, and two known isoforms…”
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Charcot–Leyden crystal protein/galectin-10 is a surrogate biomarker of eosinophilic airway inflammation in asthma by Nyenhuis, Sharmilee M, Alumkal, Preeth, Du, Jian, Maybruck, Brian T, Vinicky, Mark, Ackerman, Steven J

“…Eosinophilic asthma is associated with more exacerbations and differential responses to treatment. The aim of this study was to assess if CLC/Gal-10 and MBP-1…”
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Autotaxin Production of Lysophosphatidic Acid Mediates Allergic Asthmatic Inflammation by GYE YOUNG PARK, YONG GYU LEE, JING DENG, RANJAN, Ravi, LEI XIAO, ARI JAFFE, H, CORBRIDGE, Susan J, KELLY, Elizabeth A. B, JARJOUR, Nizar N, CHUN, Jerold, PRESTWICH, Glenn D, KAFFE, Eleanna, BERDYSHEV, Evgeny, NINOU, Ioanna, AIDINIS, Vassilis, MORRIS, Andrew J, SMYTH, Susan S, ACKERMAN, Steven J, NATARAJAN, Viswanathan, CHRISTMAN, John W, SHARMILEE NYENHUIS, JIAN DU, PANFENG FU, GORSHKOVA, Irina A, YONGCHAO LI, SANGWOON CHUNG, KARPURAPU, Manjula

“…Bioactive lipid mediators, derived from membrane lipid precursors, are released into the airway and airspace where they bind high-affinity cognate receptors…”
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Revisiting the NIH Taskforce on the Research needs of Eosinophil‐Associated Diseases (RE‐TREAD) by Khoury, Paneez, Akuthota, Praveen, Ackerman, Steven J., Arron, Joseph R., Bochner, Bruce S., Collins, Margaret H., Kahn, Jean‐Emmanuel, Fulkerson, Patricia C., Gleich, Gerald J., Gopal‐Srivastava, Rashmi, Jacobsen, Elizabeth A., Leiferman, Kristen M., Francesca, Levi‐Schaffer, Mathur, Sameer K., Minnicozzi, Michael, Prussin, Calman, Rothenberg, Marc E., Roufosse, Florence, Sable, Kathleen, Simon, Dagmar, Simon, Hans‐Uwe, Spencer, Lisa A., Steinfeld, Jonathan, Wardlaw, Andrew J., Wechsler, Michael E., Weller, Peter F., Klion, Amy D.

“…Eosinophil‐associated diseases (EADs) are rare, heterogeneous disorders characterized by the presence of eosinophils in tissues and/or peripheral blood…”
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Relationships Between Eosinophilic Inflammation, Tissue Remodeling, and Fibrosis in Eosinophilic Esophagitis by Aceves, Seema S., MD, PhD, Ackerman, Steven J., PhD

“…The clinical and pathologic features of eosinophilic esophagitis (EE) include extensive tissue remodeling. Increasing evidence supports a key role for the…”
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Race is associated with differences in airway inflammation in patients with asthma by Nyenhuis, Sharmilee M., MD, Krishnan, Jerry A., MD, PhD, Berry, Alalia, MD, Calhoun, William J., MD, Chinchilli, Vernon M., PhD, Engle, Linda, BS, Grossman, Nicole, MD, Holguin, Fernando, MD, MPH, Israel, Elliot, MD, Kittles, Rick A., PhD, Kraft, Monica, MD, Lazarus, Stephen C., MD, Lehman, Erik B., MS, Mauger, David T., PhD, Moy, James N., MD, Peters, Stephen P., MD, PhD, Phipatanakul, Wanda, MD, MS, Smith, Lewis J., MD, Sumino, Kaharu, MD, MPH, Szefler, Stanley J., MD, Wechsler, Michael E., MD, MMSc, Wenzel, Sally, MD, White, Steven R., MD, Ackerman, Steven J., PhD

“…Background African American subjects have a greater burden from asthma compared with white subjects. Whether the pattern of airway inflammation differs between…”
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Sputum eosinophil peroxidase: Building a better biomarker for eosinophilic asthma by Ackerman, Steven J.

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Biomarkers of the involvement of mast cells, basophils and eosinophils in asthma and allergic diseases by Metcalfe, Dean D., Pawankar, Ruby, Ackerman, Steven J., Akin, Cem, Clayton, Frederic, Falcone, Franco H., Gleich, Gerald J., Irani, Anne-Marie, Johansson, Mats W., Klion, Amy D., Leiferman, Kristin M., Levi-Schaffer, Francesca, Nilsson, Gunnar, Okayama, Yoshimichi, Prussin, Calman, Schroeder, John T., Schwartz, Lawrence B., Simon, Hans-Uwe, Walls, Andrew F., Triggiani, Massimo

“…Biomarkers of disease activity have come into wide use in the study of mechanisms of human disease and in clinical medicine to both diagnose and predict…”
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Polyunsaturated lysophosphatidic acid as a potential asthma biomarker by Ackerman, Steven J, Park, Gye Young, Christman, John W, Nyenhuis, Sharmilee, Berdyshev, Evgeny, Natarajan, Viswanathan

“…Lysophosphatidic acid (LPA), a lipid mediator in biological fluids and tissues, is generated mainly by autotaxin that hydrolyzes lysophosphatidylcholine to LPA…”
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Eosinophil Granule Proteins: Form and Function by Acharya, K. Ravi, Ackerman, Steven J.

“…Experimental and clinical data strongly support a role for the eosinophil in the pathogenesis of asthma, allergic and parasitic diseases, and hypereosinophilic…”
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