Search Results - "Ackerman, L L"

mRNA Translation Gone Awry: Translation Fidelity and Neurological Disease by Kapur, Mridu, Ackerman, Susan L.

“…Errors during mRNA translation can lead to a reduction in the levels of functional proteins and an increase in deleterious molecules. Advances in…”
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Regulation of mRNA Translation in Neurons—A Matter of Life and Death by Kapur, Mridu, Monaghan, Caitlin E., Ackerman, Susan L.

“…Dynamic regulation of mRNA translation initiation and elongation is essential for the survival and function of neural cells. Global reductions in translation…”
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Ribosome stalling induced by mutation of a CNS-specific tRNA causes neurodegeneration by Ishimura, Ryuta, Nagy, Gabor, Dotu, Ivan, Zhou, Huihao, Yang, Xiang-Lei, Schimmel, Paul, Senju, Satoru, Nishimura, Yasuharu, Chuang, Jeffrey H., Ackerman, Susan L.

“…In higher eukaryotes, transfer RNAs (tRNAs) with the same anticodon are encoded by multiple nuclear genes, and little is known about how mutations in these…”
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Promising precision medicine: how patients, clinicians and caregivers work to realize the potential of genomics-informed cancer care by Ackerman, Sara L.

“…This paper examines the emerging field of molecular oncology, in which targeted treatments are sought for patients who have exhausted standard cancer…”
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Mutation of a U2 snRNA Gene Causes Global Disruption of Alternative Splicing and Neurodegeneration by Jia, Yichang, Mu, John C., Ackerman, Susan L.

“…Although uridine-rich small nuclear RNAs (U-snRNAs) are essential for pre-mRNA splicing, little is known regarding their function in the regulation of…”
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Endothelial Unc5B controls blood-brain barrier integrity by Boyé, Kevin, Geraldo, Luiz Henrique, Furtado, Jessica, Pibouin-Fragner, Laurence, Poulet, Mathilde, Kim, Doyeun, Nelson, Bryce, Xu, Yunling, Jacob, Laurent, Maissa, Nawal, Agalliu, Dritan, Claesson-Welsh, Lena, Ackerman, Susan L., Eichmann, Anne

“…Blood-brain barrier (BBB) integrity is critical for proper function of the central nervous system (CNS). Here, we show that the endothelial Unc5B receptor…”
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Mechanisms controlling giant sea salt aerosol size distributions along a tropical orographic coastline by Ackerman, Katherine L, Nugent, Alison D, Taing, Chung

“…Sea salt aerosol (SSA) is a naturally occurring phenomenon that arises from the breaking of waves and consequent bubble bursting on the ocean's surface. The…”
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Regulation of ex-translational activities is the primary function of the multi-tRNA synthetase complex by Cui, Haissi, Kapur, Mridu, Diedrich, Jolene K, Yates, John R, Ackerman, Susan L, Schimmel, Paul

“…Abstract During mRNA translation, tRNAs are charged by aminoacyl-tRNA synthetases and subsequently used by ribosomes. A multi-enzyme aminoacyl-tRNA synthetase…”
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Activation of GCN2 kinase by ribosome stalling links translation elongation with translation initiation by Ishimura, Ryuta, Nagy, Gabor, Dotu, Ivan, Chuang, Jeffrey H, Ackerman, Susan L

“…Ribosome stalling during translation has recently been shown to cause neurodegeneration, yet the signaling pathways triggered by stalled elongation complexes…”
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Mutations in the microtubule-associated protein 1A (Map1a) gene cause Purkinje cell degeneration by Liu, Ye, Lee, Jeong Woong, Ackerman, Susan L

“…The structural microtubule-associated proteins (MAPs) are critical for the organization of neuronal microtubules (MTs). Microtubule-associated protein 1A…”
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Working Memory and Intelligence: The Same or Different Constructs? by Ackerman, Phillip L, Beier, Margaret E, Boyle, Mary O

“…Several investigators have claimed over the past decade that working memory (WM) and general intelligence ( g ) are identical, or nearly identical, constructs,…”
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A Role for the Endoplasmic Reticulum Protein Retrotranslocation Machinery during Crosspresentation by Dendritic Cells by Ackerman, Anne L., Giodini, Alessandra, Cresswell, Peter

“…Crosspresentation of exogenous antigens (Ags) to CD8 + T cells by dendritic cells generally requires their entry into the cytosol. Here we show that both…”
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Anomalous Dynamical Behavior of Freestanding Graphene Membranes by Ackerman, M L, Kumar, P, Neek-Amal, M, Thibado, P M, Peeters, F M, Singh, Surendra

“…We report subnanometer, high-bandwidth measurements of the out-of-plane (vertical) motion of atoms in freestanding graphene using scanning tunneling…”
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An Official American Thoracic Society Clinical Practice Guideline: Pediatric Chronic Home Invasive Ventilation by Sterni, Laura M, Collaco, Joseph M, Baker, Christopher D, Carroll, John L, Sharma, Girish D, Brozek, Jan L, Finder, Jonathan D, Ackerman, Veda L, Arens, Raanan, Boroughs, Deborah S, Carter, Jodi, Daigle, Karen L, Dougherty, Joan, Gozal, David, Kevill, Katharine, Kravitz, Richard M, Kriseman, Tony, MacLusky, Ian, Rivera-Spoljaric, Katherine, Tori, Alvaro J, Ferkol, Thomas, Halbower, Ann C

“…Children with chronic invasive ventilator dependence living at home are a diverse group of children with special health care needs. Medical oversight,…”
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Prenatal diagnosis of Down syndrome: a systematic review of termination rates (1995-2011) by Natoli, Jaime L., Ackerman, Deborah L., McDermott, Suzanne, Edwards, Janice G.

“…ABSTRACT Objective The objective of this study was to review the published literature on pregnancy termination following a prenatal diagnosis of Down syndrome…”
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Intelligence Process vs. Content and Academic Performance: A Trip through a House of Mirrors by Ackerman, Phillip L

“…The main purpose of modern intelligence tests has been to predict individual differences in academic performance, first of children, then adolescents, and…”
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Goals and motivation related to work in later adulthood: An organizing framework by Kanfer, Ruth, Beier, Margaret E., Ackerman, Phillip L.

“…Demographics of workforce aging in the developed world have spurred research on the determinants of older worker motivation to work, motivation to retire, and…”
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A deficiency of ceramide biosynthesis causes cerebellar purkinje cell neurodegeneration and lipofuscin accumulation by Zhao, Lihong, Spassieva, Stefka D, Jucius, Thomas J, Shultz, Leonard D, Shick, H Elizabeth, Macklin, Wendy B, Hannun, Yusuf A, Obeid, Lina M, Ackerman, Susan L

“…Sphingolipids, lipids with a common sphingoid base (also termed long chain base) backbone, play essential cellular structural and signaling functions…”
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Aging, Adult Development, and Work Motivation by Kanfer, Ruth, Ackerman, Phillip L.

“…We describe a framework for understanding how age-related changes in adult development affect work motivation, and, building on recent life-span theories and…”
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Notch signaling regulates UNC5B to suppress endothelial proliferation, migration, junction activity, and retinal plexus branching by Raza, Qanber, Nadeem, Taliha, Youn, Seock-Won, Swaminathan, Bhairavi, Gupta, Ahana, Sargis, Timothy, Du, Jing, Cuervo, Henar, Eichmann, Anne, Ackerman, Susan L., Naiche, L. A., Kitajewski, Jan

“…Notch signaling guides vascular development and function by regulating diverse endothelial cell behaviors, including migration, proliferation, vascular…”
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