Search Results - "Ackerman, Joseph J.H."

Specificity of vascular endothelial growth factor treatment for radiation necrosis by Perez-Torres, Carlos J, Yuan, Liya, Schmidt, Robert E, Rich, Keith M, Drzymala, Robert E, Hallahan, Dennis E, Ackerman, Joseph J.H, Garbow, Joel R

“…Abstract Recently, radiation induced necrosis in the brain has been treated using bevacizumab, an anti-VEGF antibody. We validated the VEGF specificity by…”
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Intracellular water preexchange lifetime in neurons and astrocytes by Yang, Donghan M., Huettner, James E., Bretthorst, G. Larry, Neil, Jeffrey J., Garbow, Joel R., Ackerman, Joseph J.H.

“…Purpose To determine the intracellular water preexchange lifetime, τi, the “average residence time” of water, in the intracellular milieu of neurons and…”
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Impaired prostate tumorigenesis in Egr1-deficient mice by Milbrandt, Jeffrey, Abdulkadir, Sarki A, Qu, Zhican, Garabedian, Emily, Song, Sheng-Kwei, Peters, Thomas J, Svaren, John, Carbone, Joseph M, Naughton, Cathy K, Catalona, William J, Ackerman, Joseph J.H, Gordon, Jeffrey I, Humphrey, Peter A

“…The transcription factor early growth response protein 1 (EGR1) is overexpressed in a majority of human prostate cancers and is implicated in the regulation of…”
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Late Effects of Radiation Prime the Brain Microenvironment for Accelerated Tumor Growth by Duan, Chong, Yang, Ruimeng, Yuan, Liya, Engelbach, John A., Tsien, Christina I., Rich, Keith M., Dahiya, Sonika M., Johanns, Tanner M., Ackerman, Joseph J.H., Garbow, Joel R.

“…Glioblastoma (GBM) remains incurable, despite state-of-the-art treatment involving surgical resection, chemotherapy, and radiation. GBM invariably recurs as a…”
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Anti-VEGF Antibodies Mitigate the Development of Radiation Necrosis in Mouse Brain by XIAOYU JIANG, ENGELBACH, John A, GARBOW, Joel R, LIYA YUAN, CATES, Jeremy, FENG GAO, DRZYMALA, Robert E, HALLAHAN, Dennis E, RICH, Keith M, SCHMIDT, Robert E, ACKERMAN, Joseph J. H

“…To quantify the effectiveness of anti-VEGF antibodies (bevacizumab and B20-4.1.1) as mitigators of radiation-induced, central nervous system (brain) necrosis…”
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Magnetic resonance diffusion characteristics of histologically defined prostate cancer in humans by Xu, Junqian, Humphrey, Peter A., Kibel, Adam S., Snyder, Abraham Z., Narra, Vamsidhar R., Ackerman, Joseph J.H., Song, Sheng-Kwei

“…The contrast provided by diffusion‐sensitive magnetic resonance offers the promise of improved tumor localization in organ‐confined human prostate cancer…”
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Statistical model for diffusion attenuated MR signal by Yablonskiy, Dmitriy A., Bretthorst, G. Larry, Ackerman, Joseph J.H.

“…A general statistical model that can describe a rather large number of experimental results related to the structure of the diffusion‐attenuated MR signal in…”
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Toward Distinguishing Recurrent Tumor From Radiation Necrosis: DWI and MTC in a Gamma Knife–Irradiated Mouse Glioma Model by Perez-Torres, Carlos J., PhD, Engelbach, John A., AS, Cates, Jeremy, PhD, Thotala, Dinesh, PhD, Yuan, Liya, PhD, Schmidt, Robert E., MD, PhD, Rich, Keith M., MD, Drzymala, Robert E., PhD, Ackerman, Joseph J.H., PhD, Garbow, Joel R., PhD

“…Purpose Accurate noninvasive diagnosis is vital for effective treatment planning. Presently, standard anatomical magnetic resonance imaging (MRI) is incapable…”
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On the nature of the NAA diffusion attenuated MR signal in the central nervous system by Kroenke, Christopher D., Ackerman, Joseph J.H., Yablonskiy, Dmitriy A.

“…In the brain, on a macroscopic scale, diffusion of the intraneuronal constituent N‐acetyl‐L‐aspartate (NAA) appears to be isotropic. In contrast, on a…”
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Quantification and compensation of eddy-current-induced magnetic-field gradients by Spees, William M., Buhl, Niels, Sun, Peng, Ackerman, Joseph J.H., Neil, Jeffrey J., Garbow, Joel R.

“…[Display omitted] ► Two techniques for quantification of MRI system eddy-current effects are described. ► Bayesian approaches using freely available software…”
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A GSK-3β Inhibitor Protects Against Radiation Necrosis in Mouse Brain by Jiang, Xiaoyu, PhD, Perez-Torres, Carlos J., PhD, Thotala, Dinesh, PhD, Engelbach, John A., AS, Yuan, Liya, PhD, Cates, Jeremy, BS, Gao, Feng, MD, PhD, Drzymala, Robert E., PhD, Rich, Keith M., MD, Schmidt, Robert E., MD, PhD, Ackerman, Joseph J.H., PhD, Hallahan, Dennis E., MD, Garbow, Joel R., PhD

“…Purpose To quantify the effectiveness of SB415286, a specific inhibitor of GSK-3β, as a neuroprotectant against radiation-induced central nervous system…”
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Equilibrium water exchange between the intra- and extracellular spaces of mammalian brain by Quirk, James D., Bretthorst, G. Larry, Duong, Timothy Q., Snyder, Avi Z., Springer Jr, Charles S., Ackerman, Joseph J.H., Neil, Jeffrey J.

“…This report describes the measurement of water preexchange lifetimes and intra/extracellular content in intact, functioning mammalian brain. Intra‐ and…”
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Imaging Primary Lung Cancers in Mice to Study Radiation Biology: In Regard to Kirsch et al. ( Int J Radiat Oncol Biol Phys 2010;76:973–977) by Garbow, Joel R., Ph.D, Ackerman, Joseph J.H., Ph.D

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Observation and identification of 2-C-methyl-d-erythritol-2,4-cyclopyrophosphate in horseweed and ryegrass treated with glyphosate by Ge, Xia, d’Avignon, D. André, Ackerman, Joseph J.H., Sammons, R. Douglas

“…[Display omitted] ► In vivo31P NMR of glyphosate treated weeds. ► Glyphosate treatment leads to accumulation of MEcPP, a key intermediate of the non-mevalonate…”
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Importance of Intracellular Water Apparent Diffusion to the Measurement of Membrane Permeability by Sehy, Jonathan V., Banks, Alison A., Ackerman, Joseph J.H., Neil, Jeffrey J.

“…The exchange of water across biological membranes is of fundamental significance to both animal and plant physiology. Diffusional membrane permeability ( P d)…”
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Protein-induced water 1H MR frequency shifts: Contributions from magnetic susceptibility and exchange effects by Luo, Jie, He, Xiang, d’Avignon, D. Andre’, Ackerman, Joseph J.H., Yablonskiy, Dmitriy A.

“…Defining the biophysics underlying the remarkable MRI phase contrast reported in high field MRI studies of human brain would lead to more quantitative image…”
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Rat Brain Global Ischemia–Induced Diffusion Changes Revisited: Biophysical Modeling of the Water and NAA MR “Diffusion Signal” by Spees, William M., Sukstanskii, Alex L., Bretthorst, G. Larry, Neil, Jeffrey J., Ackerman, Joseph J.H.

“…Purpose To assess changes in intracellular diffusion as a mechanism for the reduction in water ADC that accompanies brain injury. Using NAA as a marker of…”
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Subcutaneous deuterated substrate administration in mice: An alternative to tail vein infusion by Song, Kyu‐Ho, Ge, Xia, Engelbach, John A., Thio, Liu Lin, Neil, Jeffrey J., Ackerman, Joseph J. H., Garbow, Joel R.

“…Purpose Tail‐vein catheterization and subsequent in‐magnet infusion is a common route of administration of deuterium (2H)‐labeled substrates in small‐animal…”
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Are complex DCE‐MRI models supported by clinical data? by Duan, Chong, Kallehauge, Jesper F., Bretthorst, G. Larry, Tanderup, Kari, Ackerman, Joseph J.H., Garbow, Joel R.

“…Purpose To ascertain whether complex dynamic contrast enhanced (DCE) MRI tracer kinetic models are supported by data acquired in the clinic and to determine…”
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Modeling dendrite density from magnetic resonance diffusion measurements by Jespersen, Sune N., Kroenke, Christopher D., Østergaard, Leif, Ackerman, Joseph J.H., Yablonskiy, Dmitriy A.

“…Diffusion-weighted imaging (DWI) provides a noninvasive tool to probe tissue microstructure. We propose a simplified model of neural cytoarchitecture intended…”
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