Search Results - "Ackerman, Allan W"

Role of TLR4 signaling in the nephrotoxicity of heme and heme proteins by Nath, Karl A, Belcher, John D, Nath, Meryl C, Grande, Joseph P, Croatt, Anthony J, Ackerman, Allan W, Katusic, Zvonimir S, Vercellotti, Gregory M

“…Destabilized heme proteins release heme, and free heme is toxic. Heme is now recognized as an agonist for the Toll-like receptor-4 (TLR4) receptor. This study…”
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The murine dialysis fistula model exhibits a senescence phenotype: pathobiological mechanisms and therapeutic potential by Nath, Karl A, O'Brien, Daniel R, Croatt, Anthony J, Grande, Joseph P, Ackerman, Allan W, Nath, Meryl C, Yamada, Satsuki, Terzic, Andre, Tchkonia, Tamara, Kirkland, James L, Katusic, Zvonimir S

“…There is no therapy that promotes maturation and functionality of a dialysis arteriovenous fistula (AVF). The search for such therapies largely relies on…”
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Increased production of superoxide anion contributes to dysfunction of the arteriovenous fistula by Tsapenko, Mykola V, d'Uscio, Livius V, Grande, Joseph P, Croatt, Anthony J, Hernandez, Melissa C, Ackerman, Allan W, Katusic, Zvonimir S, Nath, Karl A

“…Vascular access dysfunction causes morbidity in hemodialysis patients. This study examined the generation and pathobiological significance of superoxide anion…”
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Renal Hemodynamic, Inflammatory, and Apoptotic Responses to Lipopolysaccharide in HO-1−/− Mice by Tracz, Michal J, Juncos, Julio P, Grande, Joseph P, Croatt, Anthony J, Ackerman, Allan W, Rajagopalan, Govindarajan, Knutson, Keith L, Badley, Andrew D, Griffin, Matthew D, Alam, Jawed, Nath, Karl A

“…Lipopolysaccharide (LPS) induces the stress-responsive gene heme oxygenase-1 (HO-1). The present study examined the significance of HO-1 in response to LPS. In…”
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Induction of Heme Oxygenase-1 is a Beneficial Response in a Murine Model of Venous Thrombosis by Tracz, Michal J, Juncos, Julio P, Grande, Joseph P, Croatt, Anthony J, Ackerman, Allan W, Katusic, Zvonimir S, Nath, Karl A

“…The induction of heme oxygenase-1 (HO-1) may protect against tissue injury. The present study examines the induction of HO-1 in a murine model of venous…”
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L-4F, an apolipoprotein A-1 mimetic, dramatically improves vasodilation in hypercholesterolemia and sickle cell disease by JINGSONG OU, ZHIJUN OU, HILLERY, Cheryl A, PRITCHARD, Kirkwood A, JONES, Deron W, HOLZHAUER, Sandra, HATOUM, Ossama A, ACKERMAN, Allan W, WEIHRAUCH, Dorothee W, GUTTERMAN, David D, GUICE, Karen, OLDHAM, Keith T

“…Hypercholesterolemia and sickle cell disease (SCD) impair endothelium-dependent vasodilation by dissimilar mechanisms. Hypercholesterolemia impairs…”
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Renal upregulation of HO-1 reduces albumin-driven MCP-1 production: implications for chronic kidney disease by Murali, Narayana S, Ackerman, Allan W, Croatt, Anthony J, Cheng, Jingfei, Grande, Joseph P, Sutor, Shari L, Bram, Richard J, Bren, Gary D, Badley, Andrew D, Alam, Jawed, Nath, Karl A

“…Proteinuria contributes to chronic kidney disease by stimulating renal tubular epithelial cells to produce cytokines such as monocyte chemoattractant protein-1…”
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The Role of Interleukin-10 in the Pathophysiology of Preeclampsia by Cubro, Hajrunisa, Kashyap, Sonu, Nath, Meryl C., Ackerman, Allan W., Garovic, Vesna D.

“…Purpose of Review The pathophysiology of preeclampsia is complex and not entirely understood. A key feature in preeclampsia development is an immunological…”
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The spike protein of SARS-CoV-2 induces heme oxygenase-1: Pathophysiologic implications by Singh, Raman Deep, Barry, Michael A, Croatt, Anthony J, Ackerman, Allan W, Grande, Joseph P, Diaz, Rosa M, Vile, Richard G, Agarwal, Anupam, Nath, Karl A

“…Acute kidney injury (AKI) is both a consequence and determinant of outcomes in COVID-19. The kidney is one of the major organs infected by the causative virus,…”
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Characterization of a Model of an Arteriovenous Fistula in the Rat by Croatt, Anthony J, Grande, Joseph P, Hernandez, Melissa C, Ackerman, Allan W, Katusic, Zvonimir S, Nath, Karl A

“…Vascular access dysfunction contributes to the mortality of patients undergoing chronic hemodialysis. The present study analyzed the changes that evolve in a…”
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Heme oxygenase-2 protects against ischemic acute kidney injury: influence of age and sex by Nath, Karl A, Garovic, Vesna D, Grande, Joseph P, Croatt, Anthony J, Ackerman, Allan W, Farrugia, Gianrico, Katusic, Zvonimir S, Belcher, John D, Vercellotti, Gregory M

“…Heme oxygenase (HO) activity is exhibited by inducible (HO-1) and constitutive (HO-2) proteins. HO-1 protects against ischemic and nephrotoxic acute kidney…”
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MCP-1 Contributes to Arteriovenous Fistula Failure by JUNCOS, Julio P, GRANDE, Joseph P, LU KANG, ACKERMAN, Allan W, CROATT, Anthony J, KATUSIC, Zvonimir S, NATH, Karl A

“…Vascular access dysfunction compromises the care of patients on chronic hemodialysis. Elucidating the mechanisms of such dysfunction and devising strategies…”
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Native low-density lipoprotein induces endothelial nitric oxide synthase dysfunction: role of heat shock protein 90 and caveolin-1 by Pritchard, Kirkwood A, Ackerman, Allan W, Ou, Jingsong, Curtis, Michelle, Smalley, David M, Fontana, Jason T, Stemerman, Michel B, Sessa, William C

“…Although native LDL (n-LDL) is well recognized for inducing endothelial cell (EC) dysfunction, the mechanisms remain unclear. One hypothesis is n-LDL increases…”
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Expression of ACE2 in the Intact and Acutely Injured Kidney by Nath, Karl A, Singh, Raman Deep, Grande, Joseph P, Garovic, Vesna D, Croatt, Anthony J, Ackerman, Allan W, Barry, Michael A, Agarwal, Anupam

“…The actions of angiotensin-converting enzyme 2 (ACE2) oppose those of the renin-angiotensin-aldosterone system. ACE2 may be a cytoprotectant in some tissues…”
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The Occurrence of Senescence in the Arteriovenous Fistula in the Rat by Nath, Karl A, Juncos, Luis A, Singh, Raman Deep, Grande, Joseph P, Croatt, Anthony J, Ackerman, Allan W, Kanamori, Karina S, Adams, Christopher M, Tchkonia, Tamara, Kirkland, James L, Katusic, Zvonimir S

“…Maturational failure of dialysis arteriovenous fistulas (AVFs) not uncommonly occurs and is of considerable and timely importance. Our prior studies…”
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Characterization of a Model of an Arteriovenous Fistula in the Rat: The Effect of L-NAME by CROATT, Anthony J, GRANDE, Joseph P, HERNANDEZ, Melissa C, ACKERMAN, Allan W, KATUSIC, Zvonimir S, NATH, Karl A

“…Vascular access dysfunction contributes to the mortality of patients undergoing chronic hemodialysis. The present study analyzed the changes that evolve in a…”
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KLF11 Is a Novel Endogenous Protectant against Renal Ischemia-Reperfusion Injury by Nath, Karl A, Singh, Raman Deep, Croatt, Anthony J, Ackerman, Allan W, Grande, Joseph P, Khazaie, Khasayarsha, Chen, Y Eugene, Zhang, Jifeng

“…Discovering new nephroprotectants may provide therapeutic strategies in AKI.This study provides the first evidence that KLF11, a member of the Krüppel-like…”
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Induction of p16Ink4a Gene Expression in Heme Protein-Induced AKI and by Heme: Pathophysiologic Implications by Nath, Karl A, Singh, Raman Deep, Croatt, Anthony J, Ackerman, Allan W, Grande, Joseph P, O'Brien, Daniel R, Garovic, Vesna D, Adams, Christopher M, Tchkonia, Tamara, Kirkland, James L

“…Key Points In heme protein–mediated AKI (HP-AKI), a senescence phenotype promptly occurs, and increased expression of p16 Ink4a contributes to HP-AKI. Renal…”
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Prominent Mitochondrial Injury as an Early Event in Heme Protein-Induced Acute Kidney Injury by Singh, Raman Deep, Croatt, Anthony J, Ackerman, Allan W, Grande, Joseph P, Trushina, Eugenia, Salisbury, Jeffrey L, Christensen, Trace A, Adams, Christopher M, Tchkonia, Tamara, Kirkland, James L, Nath, Karl A

“…Mitochondrial injury occurs in and underlies acute kidney injury (AKI) caused by ischemia-reperfusion and other forms of renal injury. However, to date, a…”
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Heat Shock Protein 90 Mediates the Balance of Nitric Oxide and Superoxide Anion from Endothelial Nitric-oxide Synthase by Pritchard, Kirkwood A., Ackerman, Allan W., Gross, Eric R., Stepp, David W., Shi, Yang, Fontana, Jason T., Baker, John E., Sessa, William C.

“…The balance of nitric oxide (·NO) and superoxide anion (O⨪2) plays an important role in vascular biology. The association of heat shock protein 90 (Hsp90) with…”
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