Search Results - "Acker, P."

Endo-lysosomal dysregulations and late-onset Alzheimer's disease: impact of genetic risk factors by Van Acker, Zoë P, Bretou, Marine, Annaert, Wim

“…Increasing evidence supports that cellular dysregulations in the degradative routes contribute to the initiation and progression of neurodegenerative diseases,…”
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Mitochondrial dysfunction, cause or consequence in neurodegenerative diseases? by Van Acker, Zoë P, Leroy, Thomas, Annaert, Wim

“…Neurodegenerative diseases encompass a spectrum of conditions characterized by the gradual deterioration of neurons in the central and peripheral nervous…”
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The microglial lysosomal system in Alzheimer’s disease: Guardian against proteinopathy by Van Acker, Zoë P., Perdok, Anika, Bretou, Marine, Annaert, Wim

“…•Proteopathic inflammation arises in both neurodegenerative diseases and ageing.•Involvement of glial cells in Alzheimer-neurodegeneration is gaining…”
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Phospholipase D3 degrades mitochondrial DNA to regulate nucleotide signaling and APP metabolism by Van Acker, Zoë P., Perdok, Anika, Hellemans, Ruben, North, Katherine, Vorsters, Inge, Cappel, Cedric, Dehairs, Jonas, Swinnen, Johannes V., Sannerud, Ragna, Bretou, Marine, Damme, Markus, Annaert, Wim

“…Phospholipase D3 (PLD3) polymorphisms are linked to late-onset Alzheimer’s disease (LOAD). Being a lysosomal 5’-3’ exonuclease, its neuronal substrates…”
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Neuroglobin Expression in the Brain: a Story of Tissue Homeostasis Preservation by Van Acker, Zoë P., Luyckx, Evi, Dewilde, Sylvia

“…After its discovery in 2000, the notion grew that neuroglobin, a neuronal specific heme protein, is involved in cytoprotection. To date, neuroglobin levels…”
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Trehalose-Based Polyethers for Cryopreservation and Three-Dimensional Cell Scaffolds by Diaz-Dussan, Diana, Peng, Yi-Yang, Sengupta, Jayeeta, Zabludowski, Rebecca, Adam, Madeleine K, Acker, Jason P, Ben, Robert N, Kumar, Piyush, Narain, Ravin

“…The capability to slow ice growth and recrystallization is compulsory in the cryopreservation of cells and tissues to avoid injuries associated with the…”
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Accumulation of APP C-terminal fragments causes endolysosomal dysfunction through the dysregulation of late endosome to lysosome-ER contact sites by Bretou, Marine, Sannerud, Ragna, Escamilla-Ayala, Abril, Leroy, Tom, Vrancx, Céline, Van Acker, Zoë P, Perdok, Anika, Vermeire, Wendy, Vorsters, Inge, Van Keymolen, Sophie, Maxson, Michelle, Pavie, Benjamin, Wierda, Keimpe, Eskelinen, Eeva-Liisa, Annaert, Wim

“…Neuronal endosomal and lysosomal abnormalities are among the early changes observed in Alzheimer's disease (AD) before plaques appear. However, it is unclear…”
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Storage of red blood cells affects membrane composition, microvesiculation, and in vitro quality by Almizraq, Ruqayyah, Tchir, Jayme D.R., Holovati, Jelena L., Acker, Jason P.

“…Background During storage detrimental biochemical and biomechanical changes occur within a red blood cell (RBC). RBC microparticles (RMPs) produced during…”
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The timing of gamma irradiation and its effect on cell‐free and microvesicle‐bound hemoglobin. The BEST collaborative study by William, Nishaka, Bicahlo, Beatriz, Hansen, Adele, Korte, Dirk, Acker, Jason P.

“…Background Gamma irradiation of red cell concentrates (RCCs) is regularly used to prevent transfusion‐associated graft‐versus‐host disease (TA‐GvHD) in at‐risk…”
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Transfusion of female blood in a rat model is associated with red blood cells entrapment in organs by Alshalani, Abdulrahman, de Wissel, Marit B, Tuip-de Boer, Anita M, Roelofs, Joris J. T. H, van Bruggen, Robin, Acker, Jason P, Juffermans, Nicole P

“…Transfusion of red blood cells (RBCs) has been associated with adverse outcomes. Mechanisms may be related to donor sex and biological age of RBC. This study…”
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Neuroglobin Expression Models as a Tool to Study Its Function by Dewilde, Sylvia, Ponsaerts, Peter, Van Acker, Zoë P., Luyckx, Evi

“…Neuroglobin (Ngb) is an evolutionary conserved member of the globin family with a primary expression in neurons of which the exact functions remain elusive. A…”
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The Grand Challenges of Organ Banking: Proceedings from the first global summit on complex tissue cryopreservation by Lewis, Jedediah K., Bischof, John C., Braslavsky, Ido, Brockbank, Kelvin G.M., Fahy, Gregory M., Fuller, Barry J., Rabin, Yoed, Tocchio, Alessandro, Woods, Erik J., Wowk, Brian G., Acker, Jason P., Giwa, Sebastian

“…The first Organ Banking Summit was convened from Feb. 27 - March 1, 2015 in Palo Alto, CA, with events at Stanford University, NASA Research Park, and Lawrence…”
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Small molecule ice recrystallization inhibitors mitigate red blood cell lysis during freezing, transient warming and thawing by Briard, Jennie G., Poisson, Jessica S., Turner, Tracey R., Capicciotti, Chantelle J., Acker, Jason P., Ben, Robert N.

“…During cryopreservation, ice recrystallization is a major cause of cellular damage. Conventional cryoprotectants such as dimethyl sulfoxide (DMSO) and glycerol…”
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Non-Methylation-Linked Mechanism of REST-Induced Neuroglobin Expression Impacts Mitochondrial Phenotypes in a Mouse Model of Amyotrophic Lateral Sclerosis by Van Acker, Zoë P., Declerck, Ken, Luyckx, Evi, Vanden Berghe, Wim, Dewilde, Sylvia

“…Neuroglobin (Ngb) is a REST/NRSF-regulated protein, active in reactive oxygen species detoxification and cytochrome c inhibition, which provides a beneficial…”
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Impact of technical and assay variation on reporting of hemolysis in stored red blood cell products by Almizraq, Ruqayyah J., Yi, Qi Long, Acker, Jason P.

“…Hemolysis of RBCs is an important measure of product quality and is influenced by donor factors, blood component manufacturing and storage. Percent hemolysis…”
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Ice recrystallization inhibitors enable efficient cryopreservation of induced pluripotent stem cells: A functional and transcriptomic analysis by Mommaerts, Kathleen, Okawa, Satoshi, Schmitt, Margaux, Kofanova, Olga, Turner, Tracey R., Ben, Robert N., Del Sol, Antonio, Mathieson, William, Schwamborn, Jens C., Acker, Jason P., Betsou, Fay

“…•Cryopreservation protocols development for induced pluripotent stem cells (iPSCs).•We assessed ice recrystallization inhibitors (IRIs) for iPSCs…”
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Buffy coat (top/bottom)- and whole-blood filtration (top/top)-produced red cell concentrates differ in size of extracellular vesicles by Bicalho, B., Pereira, A. S., Acker, J. P.

“…Background and Objectives The influence that blood component separation methods have on changes to the red blood cell membrane during storage is not well…”
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Comparing two extracellular additives to facilitate extended storage of red blood cells in a supercooled state by William, Nishaka, Isiksacan, Ziya, Mykhailova, Olga, Olafson, Carly, Yarmush, Martin L, Usta, O Berk, Acker, Jason P

“…Adenosine triphosphate (ATP) levels guide many aspects of the red blood cell (RBC) hypothermic storage lesions. As a result, efforts to improve the quality of…”
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Evaluating the quality of red blood cell concentrates irradiated before or after cryopreservation by Turner, Tracey R., Lautner, Larissa, Hill, Angela, Howell, Anita, Skeate, Robert, Acker, Jason P.

“…BACKGROUND Cryopreserved red blood cell concentrates (RCCs) are often required for patients with rare blood groups. Although transfusions from blood relatives…”
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Characterisation of Gel-Forming Mucins Produced In Vivo and In Ex Vivo Conjunctival Explant Cultures by Van Acker, Sara I., Van den Bogerd, Bert, Van Acker, Zoë P., Vailionytė, Agnė, Haagdorens, Michel, Koppen, Carina, Ní Dhubhghaill, Sorcha, Dartt, Darlene A., Pintelon, Isabel

“…One key element to the health of the ocular surface encompasses the presence of gel-forming mucins in the pre-ocular tear film. Conjunctival goblet cells are…”
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