Search Results - "Achuthan, Adrian"

Colony stimulating factors and myeloid cell biology in health and disease by Hamilton, John A, Achuthan, Adrian

“…The colony stimulating factors (CSFs), granulocyte macrophage-CSF (GM-CSF), macrophage-CSF (M-CSF or CSF-1) and granulocyte-CSF (G-CSF) were first identified…”
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Macrophage spatial heterogeneity in gastric cancer defined by multiplex immunohistochemistry by Huang, Yu-Kuan, Wang, Minyu, Sun, Yu, Di Costanzo, Natasha, Mitchell, Catherine, Achuthan, Adrian, Hamilton, John A., Busuttil, Rita A., Boussioutas, Alex

“…Tumor-associated macrophages (TAMs), one of the most abundant immune components in gastric cancer (GC), are difficult to characterize due to their…”
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Targeting transcription factors for therapeutic benefit in rheumatoid arthritis by Balendran, Thivya, Lim, Keith, Hamilton, John A, Achuthan, Adrian A

“…Rheumatoid arthritis (RA) is a destructive inflammatory autoimmune disease that causes pain and disability. Many of the currently available drugs for treating…”
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Transforming growth factor-β in tumor microenvironment: Understanding its impact on monocytes and macrophages for its targeting by Hourani, Tetiana, Sharma, Amit, Luwor, Rodney B, Achuthan, Adrian A

“…TGF-β is a pivotal cytokine that orchestrates various aspects of cancer progression, including tumor growth, metastasis, and immune evasion. In this review, we…”
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Targeting GM-CSF in inflammatory and autoimmune disorders by Achuthan, Adrian A., Lee, Kevin M.C., Hamilton, John A.

“…Granulocyte macrophage-colony stimulating factor (GM-CSF) was originally identified as a growth factor for its ability to promote the proliferation and…”
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Defining GM-CSF- and macrophage-CSF-dependent macrophage responses by in vitro models by Lacey, Derek C, Achuthan, Adrian, Fleetwood, Andrew J, Dinh, Hang, Roiniotis, John, Scholz, Glen M, Chang, Melody W, Beckman, Sandra K, Cook, Andrew D, Hamilton, John A

“…GM-CSF and M-CSF (CSF-1) induce different phenotypic changes in macrophage lineage populations. The nature, extent, and generality of these differences were…”
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Label-free macrophage phenotype classification using machine learning methods by Hourani, Tetiana, Perez-Gonzalez, Alexis, Khoshmanesh, Khashayar, Luwor, Rodney, Achuthan, Adrian A., Baratchi, Sara, O’Brien-Simpson, Neil M., Al-Hourani, Akram

“…Macrophages are heterogeneous innate immune cells that are functionally shaped by their surrounding microenvironment. Diverse macrophage populations have…”
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Introduction to the Special Issue: The regulation of the immune system by colony stimulating factors (CSFs) in the steady state and pathology by Hamilton, John A., Achuthan, Adrian A.

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CCL17/TARC in autoimmunity and inflammation—not just a T‐cell chemokine by Lupancu, Tanya J, Eivazitork, Mahtab, Hamilton, John A, Achuthan, Adrian A, Lee, Kevin M‐C

“…Chemokine (C–C) ligand 17 (CCL17) was first identified as thymus‐ and activation‐regulated chemokine when it was found to be constitutively expressed in the…”
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IL-23p19 in osteoarthritic pain and disease by Lee, Kevin M.-C., Lupancu, Tanya, Achuthan, Adrian A., de Steiger, Richard, Hamilton, John A.

“…We have previously reported that the interleukin-23 p19 subunit (IL-23p19) is required for experimental inflammatory arthritic pain-like behavior and disease…”
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Epigenetic and transcriptional regulation of cytokine production by Plasmodium falciparum-exposed monocytes by Romero, David V. L., Balendran, Thivya, Hasang, Wina, Rogerson, Stephen J., Aitken, Elizabeth H., Achuthan, Adrian A.

“…Plasmodium falciparum infection causes the most severe form of malaria, where excessive production of proinflammatory cytokines can drive the pathogenesis of…”
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CCL17 blockade as a therapy for osteoarthritis pain and disease by Lee, Ming-Chin, Saleh, Reem, Achuthan, Adrian, Fleetwood, Andrew J, Förster, Irmgard, Hamilton, John A, Cook, Andrew D

“…Granulocyte macrophage-colony stimulating factor (GM-CSF) has been implicated in the pathogenesis of a number of inflammatory diseases and in osteoarthritis…”
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Epigenetic and transcriptional regulation of IL4-induced CCL17 production in human monocytes and murine macrophages by Hsu, Amy T., Lupancu, Tanya J., Lee, Ming-Chin, Fleetwood, Andrew J., Cook, Andrew D., Hamilton, John A., Achuthan, Adrian

“…Interleukin 4 (IL4) is generally viewed as a Th2 cytokine capable of polarizing macrophages into an anti-inflammatory phenotype, whereas granulocyte…”
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GM-CSF: A Promising Target in Inflammation and Autoimmunity by Lee, Kevin M C, Achuthan, Adrian A, Hamilton, John A

“…The cytokine, granulocyte macrophage-colony stimulating factor (GM-CSF), was firstly identified as being able to induce in vitro the proliferation and…”
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Metabolic Remodeling, Inflammasome Activation, and Pyroptosis in Macrophages Stimulated by Porphyromonas gingivalis and Its Outer Membrane Vesicles by Fleetwood, Andrew J, Lee, Man K S, Singleton, William, Achuthan, Adrian, Lee, Ming-Chin, O'Brien-Simpson, Neil M, Cook, Andrew D, Murphy, Andrew J, Dashper, Stuart G, Reynolds, Eric C, Hamilton, John A

“…is one of the bacterial species most closely associated with periodontitis and can shed large numbers of outer membrane vesicles (OMVs), which are increasingly…”
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Granulocyte macrophage colony-stimulating factor induces CCL17 production via IRF4 to mediate inflammation by Achuthan, Adrian, Cook, Andrew D, Lee, Ming-Chin, Saleh, Reem, Khiew, Hsu-Wei, Chang, Melody W N, Louis, Cynthia, Fleetwood, Andrew J, Lacey, Derek C, Christensen, Anne D, Frye, Ashlee T, Lam, Pui Yeng, Kusano, Hitoshi, Nomura, Koji, Steiner, Nancy, Förster, Irmgard, Nutt, Stephen L, Olshansky, Moshe, Turner, Stephen J, Hamilton, John A

“…Data from preclinical and clinical studies have demonstrated that granulocyte macrophage colony-stimulating factor (GM-CSF) can function as a key…”
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Signaling pathways underlying TGF-β mediated suppression of IL-12A gene expression in monocytes by Hourani, Tetiana, Eivazitork, Mahtab, Balendran, Thivya, MC. Lee, Kevin, Hamilton, John A., Zhu, Hong-Jian, Iaria, Josephine, Morokoff, Andrew P., Luwor, Rodney B., Achuthan, Adrian A.

“…Transforming growth factor-β (TGF-β) is a pleiotropic cytokine essential for multiple biological processes, including the regulation of inflammatory and immune…”
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Type I interferon antagonism of the JMJD3-IRF4 pathway modulates macrophage activation and polarization by Ming-Chin Lee, Kevin, Achuthan, Adrian A., De Souza, David P., Lupancu, Tanya J., Binger, Katrina J., Lee, Man K.S., Xu, Yangsong, McConville, Malcolm J., de Weerd, Nicole A., Dragoljevic, Dragana, Hertzog, Paul J., Murphy, Andrew J., Hamilton, John A., Fleetwood, Andrew J.

“…Metabolic adaptations can directly influence the scope and scale of macrophage activation and polarization. Here we explore the impact of type I interferon…”
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The Interleukin-11/IL-11 Receptor Promotes Glioblastoma Survival and Invasion under Glucose-Starved Conditions through Enhanced Glutaminolysis by Stuart, Sarah F, Bezawork-Geleta, Ayenachew, Areeb, Zammam, Gomez, Juliana, Tsui, Vanessa, Zulkifli, Ahmad, Paradiso, Lucia, Jones, Jordan, Nguyen, Hong P T, Putoczki, Tracy L, Licciardi, Paul V, Kannourakis, George, Morokoff, Andrew P, Achuthan, Adrian A, Luwor, Rodney B

“…Glioblastoma cells adapt to changes in glucose availability through metabolic plasticity allowing for cell survival and continued progression in low-glucose…”
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IL-23 in arthritic and inflammatory pain development in mice by Lee, Kevin M-C, Zhang, Zihao, Achuthan, Adrian, Fleetwood, Andrew J, Smith, Julia E, Hamilton, John A, Cook, Andrew D

“…The cytokine, interleukin-23 (IL-23), can be critical for the progression of inflammatory diseases, including arthritis, and is often associated with T…”
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