Search Results - "Achike, Francis"

Quercetin and pioglitazone synergistically reverse endothelial dysfunction in isolated aorta from fructose-streptozotocin (F-STZ)-induced diabetic rats by Kunasegaran, Thubasni, Mustafa, Mohd Rais, Achike, Francis I., Murugan, Dharmani Devi

“…Pioglitazone is an anti-diabetic drug with potential to cause adverse effects following prolonged use. This study, therefore, investigated the effects of…”
Get full text

Boldine protects endothelial function in hyperglycemia-induced oxidative stress through an antioxidant mechanism by Lau, Yeh Siang, Tian, Xiao Yu, Huang, Yu, Murugan, Dharmani, Achike, Francis I., Mustafa, Mohd Rais

“…Increased oxidative stress is involved in the pathogenesis and progression of diabetes. Antioxidants are therapeutically beneficial for oxidative…”
Get full text

Resources Used to Teach the Physical Exam to Preclerkship Medical Students: Results of a National Survey by Uchida, Toshiko, Achike, Francis I., Blood, Angela D., Boyle, Mary, Farnan, Jeanne M., Gowda, Deepthiman, Hojsak, Joanne, Ovitsh, Robin K., Park, Yoon Soo, Silvestri, Ronald

“…PURPOSETo examine resources used in teaching the physical exam to preclerkship students at U.S. medical schools. METHODThe Directors of Clinical Skills Courses…”
Get full text

Approaches to Teaching the Physical Exam to Preclerkship Medical Students: Results of a National Survey by Uchida, Toshiko, Park, Yoon Soo, Ovitsh, Robin K, Hojsak, Joanne, Gowda, Deepthiman, Farnan, Jeanne M, Boyle, Mary, Blood, Angela D, Achike, Francis I, Silvestri, Ronald C

“…PURPOSETo assess current approaches to teaching the physical exam to preclerkship students at U.S. medical schools. METHODThe Directors of Clinical Skills…”
Get full text

The bioflavonoid quercetin synergises with PPAR-γ agonist pioglitazone in reducing angiotensin-II contractile effect in fructose-streptozotocin induced diabetic rats by Kunasegaran, Thubasni, Mustafa, Mohd Rais, Murugan, Dharmani Devi, Achike, Francis I.

“…This study investigated the effects of combined minimal concentrations of quercetin and pioglitazone on angiotensin II-induced contraction of the aorta from…”
Get full text

Demise of the USMLE Step-2 CS exam: Rationalizing a way forward by Achike, Francis I, Christner, Jennifer G, Gibson, Jeremy L, Milman, Robert M, Obadia, Sharon, Waer, Amy L, Watson, Patricia K

“…The COVID-19 pandemic has compelled rethinking and changes in medical education, the most controversial perhaps being the cancelation of USMLE Step-2 Clinical…”
Get full text

Obesity, metabolic syndrome, adipocytes and vascular function: A holistic viewpoint by Achike, Francis I, To, Nim-Hin Peter, Wang, Huidi, Kwan, Chiu-Yin

“…Summary 1. Obesity is a metabolic disease of pandemic proportions largely arising from positive energy balance, a consequence of sedentary lifestyle,…”
Get full text

Curriculum mapping as a tool to facilitate curriculum development: a new School of Medicine experience by Al-Eyd, Ghaith, Achike, Francis, Agarwal, Mukesh, Atamna, Hani, Atapattu, Dhammika N, Castro, Lony, Estrada, John, Ettarh, Rajunor, Hassan, Sherif, Lakhan, Shaheen E, Nausheen, Fauzia, Seki, Tsugio, Stegeman, Matthew, Suskind, Robert, Velji, Anvar, Yakub, Mohsin, Tenore, Alfred

“…Every curriculum needs to be reviewed, implemented and evaluated; it must also comply with the regulatory standards. This report demonstrates the value of…”
Get full text

Advancing safe drug use through interprofessional learning (IPL): A pilot study by Achike, Francis I., Smith, John, Leonard, Stuart, Williams, Janet, Browning, Felicia, Glisson, James

“…Interprofessional collaborative patient‐centered care (IPCPC) improves healthcare quality and cost. Drug‐related morbidity drives healthcare costs, thus…”
Get full text

Teaching Pharmacology in an Innovative Medical Curriculum: Challenges of Integration, Technology, and Future Training by Achike, Francis I.

Get full text

The aporphine alkaloid boldine improves endothelial function in spontaneously hypertensive rats by Lau, Yeh-Siang, Machha, Ajay, Achike, Francis I, Murugan, Dharmani, Mustafa, Mohd Rais

“…Boldine, a major aporphine alkaloid found in Chilean boldo tree, is a potent antioxidant. Oxidative stress plays a detrimental role in the pathogenesis of…”
Get more information

Quercetin, a flavonoid antioxidant, modulates endothelium-derived nitric oxide bioavailability in diabetic rat aortas by Machha, Ajay, Achike, Francis I., Mustafa, Ali Mohd, Mustafa, Mohd Rais

“…The present work examined the effect of chronic oral administration of quercetin, a flavonoid antioxidant, on blood glucose, vascular function and oxidative…”
Get full text

The temporal and challenging faces of integration in medical education: The fate of pharmacology by Achike, Francis I

“…An editorial focuses on modern medical education and the challenges posed to, and by, the concept of integration in the medical curriculum and how this has…”
Get full text

Des-aspartate angiotensin I (DAA-I) reduces endothelial dysfunction in the aorta of the spontaneously hypertensive rat through inhibition of angiotensin II-induced oxidative stress by Loh, Wei Mee, Ling, Wei Chih, Murugan, Dharmani D, Lau, Yeh Siang, Achike, Francis I, Vanhoutte, Paul M, Mustafa, Mohd Rais

“…Abstract Des-aspartate angiotensin I (DAA-I), an endogenous nonapeptide, counteracts several effects of angiotensin II on vascular tone. The aim of this study…”
Get full text

Effect of quercetin on altered vascular reactivity in aortas isolated from streptozotocin-induced diabetic rats by Ajay, Machha, Achike, Francis I., Mustafa, Ali Mohd, Mustafa, Mohd Rais

“…The present work examined ex vivo the acute effect of quercetin on diabetic rat aortic ring reactivity in response to endothelium-dependent (acetylcholine,…”
Get full text

Nitric oxide, human diseases and the herbal products that affect the nitric oxide signalling pathway by Achike, Francis I, Kwan, Chiu-Yin

“…Summary 1. Nitric oxide (NO) is formed enzymatically from l‐arginine in the presence of nitric oxide synthase (NOS). Nitric oxide is generated constitutively…”
Get full text

Exploring the mechanism of endothelial involvement in acidosis-induced vasodilatation of aortic tissues from normal and diabetic rats by Yeo, Jian Loong, Tan, Boris Teng Chuan, Achike, Francis I.

“…Acidosis modulates physiologic and pathophysiologic processes but the mechanism of acidotic vasodilatation remains unclear. We therefore explored this in…”
Get full text

Effects of angiotensin 1-7 on the actions of angiotensin II in the renal and mesenteric vasculature of hypertensive and streptozotocin-induced diabetic rats by Dharmani, Murugan, Mustafa, Mohd. Rais, Achike, Francis I., Sim, Meng-Kwoon

“…Angiotensin 1-7, a heptapeptide derived from metabolism of either angiotensin I or angiotensin II, is a biologically active peptide of the renin–angiotensin…”
Get full text

Gender discrimination in the influence of hyperglycemia and hyperosmolarity on rat aortic tissue responses to insulin by Wong, Nikki L., Achike, Francis I.

“…Hyperglycaemia initiates endothelial dysfunction causing diabetic macro- and micro-vasculopathy, the main causes of morbidity and mortality in diabetes…”
Get full text

THE l-ARGININE-NITRIC OXIDE PATHWAY: A POTENTIAL THERAPEUTIC TARGET IN DENGUE HAEMORHAGIC FEVER by Achike, Francis I

Get full text