Search Results - "Achard, Maud E S"

Metal ions in macrophage antimicrobial pathways: emerging roles for zinc and copper by Stafford, Sian L, Bokil, Nilesh J, Achard, Maud E S, Kapetanovic, Ronan, Schembri, Mark A, McEwan, Alastair G, Sweet, Matthew J

“…The immunomodulatory and antimicrobial properties of zinc and copper have long been appreciated. In addition, these metal ions are also essential for microbial…”
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Copper redistribution in murine macrophages in response to Salmonella infection by Achard, Maud E S, Stafford, Sian L, Bokil, Nilesh J, Chartres, Jy, Bernhardt, Paul V, Schembri, Mark A, Sweet, Matthew J, McEwan, Alastair G

“…The movement of key transition metal ions is recognized to be of critical importance in the interaction between macrophages and intracellular pathogens. The…”
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Multi-Copper-Ion Oxidase CueO of Salmonella enterica Serovar Typhimurium Is Required for Systemic Virulence by Achard, Maud E.S, Tree, Jai J, Holden, James A, Simpfendorfer, Kim R, Wijburg, Odilia L.C, Strugnell, Richard A, Schembri, Mark A, Sweet, Matthew J, Jennings, Michael P, McEwan, Alastair G

“…Salmonella enterica serovar Typhimurium possesses a multi-copper-ion oxidase (multicopper oxidase), CueO (also known as CuiD), a periplasmic enzyme known to be…”
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The serum resistome of a globally disseminated multidrug resistant uropathogenic Escherichia coli clone by Phan, Minh-Duy, Peters, Kate M, Sarkar, Sohinee, Lukowski, Samuel W, Allsopp, Luke P, Gomes Moriel, Danilo, Achard, Maud E S, Totsika, Makrina, Marshall, Vikki M, Upton, Mathew, Beatson, Scott A, Schembri, Mark A

“…Escherichia coli ST131 is a globally disseminated, multidrug resistant clone responsible for a high proportion of urinary tract and bloodstream infections. The…”
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Copper Ions and Coordination Complexes as Novel Carbapenem Adjuvants by Djoko, Karrera Y, Achard, Maud E S, Phan, Minh-Duy, Lo, Alvin W, Miraula, Manfredi, Prombhul, Sasiprapa, Hancock, Steven J, Peters, Kate M, Sidjabat, Hanna E, Harris, Patrick N, Mitić, Nataša, Walsh, Timothy R, Anderson, Gregory J, Shafer, William M, Paterson, David L, Schenk, Gerhard, McEwan, Alastair G, Schembri, Mark A

“…Carbapenem-resistant are urgent threats to global human health. These organisms produce β-lactamases with carbapenemase activity, such as the…”
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Modifications in the pmrB gene are the primary mechanism for the development of chromosomally encoded resistance to polymyxins in uropathogenic Escherichia coli by Phan, Minh-Duy, Nhu, Nguyen Thi Khanh, Achard, Maud E S, Forde, Brian M, Hong, Kar Wai, Chong, Teik Min, Yin, Wai-Fong, Chan, Kok-Gan, West, Nicholas P, Walker, Mark J, Paterson, David L, Beatson, Scott A, Schembri, Mark A

“…Polymyxins remain one of the last-resort drugs to treat infections caused by MDR Gram-negative pathogens. Here, we determined the mechanisms by which…”
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Periplasmic Thioredoxin-Like Protein Plays a Role in Defense against Oxidative Stress in Neisseria gonorrhoeae by Achard, Maud E.S, Hamilton, Amanda J, Dankowski, Tarek, Heras, Begoña, Schembri, Mark S, Edwards, Jennifer L, Jennings, Michael P, McEwan, Alastair G

“…Thioredoxin-like proteins of the TlpA/ResE/CcmG subfamily are known to face the periplasm in gram-negative bacteria. Using the tlpA gene of Bradyrhizobium…”
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Combined functional genomic and metabolomic approaches identify new genes required for growth in human urine by multidrug-resistant Escherichia coli ST131 by Phan, Minh-Duy, Schirra, Horst Joachim, Nhu, Nguyen Thi Khanh, Peters, Kate M, Sarkar, Sohinee, Allsopp, Luke P, Achard, Maud E S, Kappler, Ulrike, Schembri, Mark A

“…Urinary tract infections (UTIs) are one of the most common bacterial infections in humans, with ~400 million cases across the globe each year. Uropathogenic…”
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An antioxidant role for catecholate siderophores in Salmonella by Achard, Maud E S, Chen, Kaiwen W, Sweet, Matthew J, Watts, Rebecca E, Schroder, Kate, Schembri, Mark A, McEwan, Alastair G

“…Iron acquisition is an important aspect of the host-pathogen interaction. In the case of Salmonella it is established that catecholate siderophores are…”
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A shape-shifting redox foldase contributes to Proteus mirabilis copper resistance by Furlong, Emily J., Lo, Alvin W., Kurth, Fabian, Premkumar, Lakshmanane, Totsika, Makrina, Achard, Maud E. S., Halili, Maria A., Heras, Begoña, Whitten, Andrew E., Choudhury, Hassanul G., Schembri, Mark A., Martin, Jennifer L.

“…Copper resistance is a key virulence trait of the uropathogen Proteus mirabilis . Here we show that P. mirabilis ScsC (PmScsC) contributes to this defence…”
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Author Correction: A shape-shifting redox foldase contributes to Proteus mirabilis copper resistance by Furlong, Emily J., Lo, Alvin W., Kurth, Fabian, Premkumar, Lakshmanane, Totsika, Makrina, Achard, Maud E. S., Halili, Maria A., Heras, Begoña, Whitten, Andrew E., Choudhury, Hassanul G., Schembri, Mark A., Martin, Jennifer L.

“…This Article contains errors in Fig. 1, Table 1 and the Methods section. In panel c, the labels for PmScsC and EcDsbC in the upper two curves are interchanged…”
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Structural and Functional Characterization of Three DsbA Paralogues from Salmonella enterica Serovar Typhimurium by Heras, Begoña, Totsika, Makrina, Jarrott, Russell, Shouldice, Stephen R., Gunčar, Gregor, Achard, Maud E.S., Wells, Timothy J., Argente, M. Pilar, McEwan, Alastair G., Schembri, Mark A.

“…In prototypic Escherichia coli K-12 the introduction of disulfide bonds into folding proteins is mediated by the Dsb family of enzymes, primarily through the…”
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Uropathogenic Escherichia coli employs both evasion and resistance to subvert innate immune-mediated zinc toxicity for dissemination by Stocks, Claudia J., Phan, Minh-Duy, Achard, Maud E. S., Nhu, Nguyen Thi Khanh, Condon, Nicholas D., Gawthorne, Jayde A., Lo, Alvin W., Peters, Kate M., McEwan, Alastair G., Kapetanovic, Ronan, Schembri, Mark A., Sweet, Matthew J.

“…Toll-like receptor (TLR)-inducible zinc toxicity is a recently described macrophage antimicrobial response used against bacterial pathogens. Here we…”
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Salmonella employs multiple mechanisms to subvert the TLR‐inducible zinc‐mediated antimicrobial response of human macrophages by Kapetanovic, Ronan, Bokil, Nilesh J., Achard, Maud E. S., Ong, Cheryl‐lynn Y., Peters, Kate M., Stocks, Claudia J., Phan, Minh‐Duy, Monteleone, Mercedes, Schroder, Kate, Irvine, Katharine M., Saunders, Bernadette M., Walker, Mark J., Stacey, Katryn J., McEwan, Alastair G., Schembri, Mark A., Sweet, Matthew J.

“…We aimed to characterize antimicrobial zinc trafficking within macrophages and to determine whether the professional intramacrophage pathogen Salmonella…”
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The cytochrome bd-I respiratory oxidase augments survival of multidrug-resistant Escherichia coli during infection by Shepherd, Mark, Achard, Maud E. S., Idris, Adi, Totsika, Makrina, Phan, Minh-Duy, Peters, Kate M., Sarkar, Sohinee, Ribeiro, Cláudia A., Holyoake, Louise V., Ladakis, Dimitrios, Ulett, Glen C., Sweet, Matthew J., Poole, Robert K., McEwan, Alastair G., Schembri, Mark A.

“…Nitric oxide (NO) is a toxic free radical produced by neutrophils and macrophages in response to infection. Uropathogenic Escherichia coli (UPEC) induces a…”
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Exploring the oxidative stress response mechanism triggered by environmental water samples by Neale, Peta A, Achard, Maud E S, Escher, Beate I, Leusch, Frederic D L

“…Environmental waters can contain a wide range of micropollutants. Bioanalytical test batteries using assays indicative of different stages of cellular toxicity…”
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Structural and functional characterization of ScsC, a periplasmic thioredoxin-like protein from Salmonella enterica serovar Typhimurium by Shepherd, Mark, Heras, Begoña, Achard, Maud E S, King, Gordon J, Argente, M Pilar, Kurth, Fabian, Taylor, Samantha L, Howard, Mark J, King, Nathan P, Schembri, Mark A, McEwan, Alastair G

“…The prototypical protein disulfide bond (Dsb) formation and protein refolding pathways in the bacterial periplasm involving Dsb proteins have been most…”
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The Serum Resistome of a Globally Disseminated Multidrug Resistant Uropathogenic Escherichia coli Clone: e1003834 by Phan, Minh-Duy, Peters, Kate M, Sarkar, Sohinee, Lukowski, Samuel W, Allsopp, Luke P, Moriel, Danilo Gomes, Achard, Maud ES, Totsika, Makrina, Marshall, Vikki M, Upton, Mathew, Beatson, Scott A, Schembri, Mark A

“…Escherichia coli ST131 is a globally disseminated, multidrug resistant clone responsible for a high proportion of urinary tract and bloodstream infections. The…”
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