Search Results - "Acevedo, Karla"

CuII(atsm) inhibits ferroptosis: Implications for treatment of neurodegenerative disease by Southon, Adam, Szostak, Kathryn, Acevedo, Karla M., Dent, Krista A., Volitakis, Irene, Belaidi, Abdel A., Barnham, Kevin J., Crouch, Peter J., Ayton, Scott, Donnelly, Paul S., Bush, Ashley I.

“…Background and Purpose Diacetyl‐bis(4‐methyl‐3‐thiosemicarbazonato)copperII (CuII(atsm)) ameliorates neurodegeneration and delays disease progression in mouse…”
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Comparison of five chickpea varieties, optimization of hydrolysates production and evaluation of biomarkers for type 2 diabetes by Acevedo Martínez, Karla A., Gonzalezde Mejia, Elvira

“…[Display omitted] •Hydrolysis with bromelain produced peptides with 93% DPPIV inhibition.•Peptides SFDLPAL and EVLSEVSF from legumins and albumins inhibited…”
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Copper Promotes the Trafficking of the Amyloid Precursor Protein by Acevedo, Karla M., Hung, Ya Hui, Dalziel, Andrew H., Li, Qiao-Xin, Laughton, Katrina, Wikhe, Krutika, Rembach, Alan, Roberts, Blaine, Masters, Colin L., Bush, Ashley I., Camakaris, James

“…Accumulation of the amyloid β peptide in the cortical and hippocampal regions of the brain is a major pathological feature of Alzheimer disease. Amyloid β…”
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Effect of Structural Modifications to Glyoxal-bis(thiosemicarbazonato)­copper(II) Complexes on Cellular Copper Uptake, Copper-Mediated ATP7A Trafficking, and P‑Glycoprotein Mediated Efflux by Acevedo, Karla M, Hayne, David J, McInnes, Lachlan E, Noor, Asif, Duncan, Clare, Moujalled, Diane, Volitakis, Irene, Rigopoulos, Angela, Barnham, Kevin J, Villemagne, Victor L, White, Anthony R, Donnelly, Paul S

“…Bis­(thiosemicarbazonato)­copper­(II) complexes are of interest as potential therapeutics for cancer and neurodegenerative diseases as well as imaging agents…”
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Phosphorylation of Amyloid Precursor Protein at Threonine 668 Is Essential for Its Copper-responsive Trafficking in SH-SY5Y Neuroblastoma Cells by Acevedo, Karla M., Opazo, Carlos M., Norrish, David, Challis, Leesa M., Li, Qiao-Xin, White, Anthony R., Bush, Ashley I., Camakaris, James

“…Amyloid precursor protein (APP) undergoes post-translational modification, including O- and N-glycosylation, ubiquitination, and phosphorylation as it traffics…”
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Cu II (atsm) inhibits ferroptosis: Implications for treatment of neurodegenerative disease by Southon, Adam, Szostak, Kathryn, Acevedo, Karla M, Dent, Krista A, Volitakis, Irene, Belaidi, Abdel A, Barnham, Kevin J, Crouch, Peter J, Ayton, Scott, Donnelly, Paul S, Bush, Ashley I

“…Diacetyl-bis(4-methyl-3-thiosemicarbazonato)copper (Cu (atsm)) ameliorates neurodegeneration and delays disease progression in mouse models of amyotrophic…”
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Fortification of Maize Tortilla with an Optimized Chickpea Hydrolysate and Its Effect on DPPIV Inhibition Capacity and Physicochemical Characteristics by Acevedo-Martinez, Karla A., Gonzalez de Mejia, Elvira

“…Chickpea hydrolysates have shown bioactivity towards type 2 diabetes by inhibiting dipeptidyl peptidase (DPPIV) activity. The objective was to compare the…”
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The phosphorylation of p25/TPPP by LIM kinase 1 inhibits its ability to assemble microtubules by Acevedo, Karla, Li, Rong, Soo, Priscilla, Suryadinata, Randy, Sarcevic, Boris, Valova, Valentina A., Graham, Mark E., Robinson, Phillip J., Bernard, Ora

“…LIM kinase 1 (LIMK1) is a key regulator of actin dynamics as it phosphorylates and inactivates cofilin, an actin-depolymerizing factor. LIMK1 activity is also…”
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Technological properties of chickpea (Cicer arietinum): Production of snacks and health benefits related to type‐2 diabetes by Acevedo Martinez, Karla A., Yang, Mary M., Gonzalez de Mejia, Elvira

“…Chickpea (Cicer arietinum) is one of the most consumed pulses worldwide (over 2.3 million tons enter the world market annually). Some chickpea components have…”
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Redox active metals in neurodegenerative diseases by Acevedo, Karla, Masaldan, Shashank, Opazo, Carlos M., Bush, Ashley I.

“…Copper (Cu) and iron (Fe) are redox active metals essential for the regulation of cellular pathways that are fundamental for brain function, including…”
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Apolipoprotein E potently inhibits ferroptosis by blocking ferritinophagy by Belaidi, Abdel Ali, Masaldan, Shashank, Southon, Adam, Kalinowski, Pawel, Acevedo, Karla, Appukuttan, Ambili T., Portbury, Stuart, Lei, Peng, Agarwal, Puja, Leurgans, Sue E., Schneider, Julie, Conrad, Marcus, Bush, Ashley I., Ayton, Scott

“…Allelic variation to the APOE gene confers the greatest genetic risk for sporadic Alzheimer’s disease (AD). Independent of genotype, low abundance of…”
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Selective ferroptosis vulnerability due to familial Alzheimer’s disease presenilin mutations by Greenough, Mark A., Lane, Darius J. R., Balez, Rachelle, Anastacio, Helena Targa Dias, Zeng, Zhiwen, Ganio, Katherine, McDevitt, Christopher A., Acevedo, Karla, Belaidi, Abdel Ali, Koistinaho, Jari, Ooi, Lezanne, Ayton, Scott, Bush, Ashley I.

“…Mutations in presenilin 1 and 2 ( PS1 and PS2 ) cause autosomal dominant familial Alzheimer’s disease (FAD). Ferroptosis has been implicated as a mechanism of…”
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TDP-43 mutations causing amyotrophic lateral sclerosis are associated with altered expression of RNA-binding protein hnRNP K and affect the Nrf2 antioxidant pathway by Moujalled, Diane, Grubman, Alexandra, Acevedo, Karla, Yang, Shu, Ke, Yazi D, Moujalled, Donia M, Duncan, Clare, Caragounis, Aphrodite, Perera, Nirma D, Turner, Bradley J, Prudencio, Mercedes, Petrucelli, Leonard, Blair, Ian, Ittner, Lars M, Crouch, Peter J, Liddell, Jeffrey R, White, Anthony R

“…TAR DNA binding protein 43 (TDP-43) is a major disease-associated protein involved in the pathogenesis of amyotrophic lateral sclerosis (ALS) and…”
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Apolipoprotein E potently inhibits ferroptosis by blocking ferritinophagy by Belaidi, Abdel Ali, Masaldan, Shashank, Southon, Adam, Kalinowski, Pawel, Acevedo, Karla, Appukuttan, Ambili, Portbury, Stuart, Lei, Peng, Agarwal, Puja, Leurgans, Sue E., Schneider, Julie A, Conrad, Marcus, Bush, Ashley I, Ayton, Scott

“…Background Allelic variation to the APOE gene confers the greatest genetic risk for sporadic Alzheimer’s disease (AD). Independent of genotype, low abundance…”
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LIM Kinase 2 Is Widely Expressed in All Tissues by Acevedo, Karla, Moussi, Nathalie, Li, Rong, Soo, Priscilla, Bernard, Ora

“…The LIM kinase family includes two proteins: LIMK1 and LIMK2. These proteins have identical genomic structure and overall amino acid identity of 50%. Both…”
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Prevalence of pathogenic or likely pathogenic germline variants in cancer predisposition genes among selected patients with lung adenocarcinoma: The GERMLUNG study by Arrieta, Oscar, Caballé-Pérez, Enrique, Hernández-Pedro, Norma, Romero-Nuñez, Eunice, Lucio-Lozada, José, Castillo-Ruiz, Cesar, Acevedo-Castillo, Karla, María Álvarez-Gómez, Rosa, Molina-Garay, Carolina, Jiménez-Olivares, Marco, Carrillo-Sánchez, Karol, Cristina Mendoza-Caamal, Elvia, Cardona, Andrés F., Remon, Jordi, Alaez-Verson, Carmen

“…[Display omitted] •A high pathogenic or likely pathogenic germline variants prevalence was identified based on our selection criteria.•Pathogenic or likely…”
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Formación alumnos de la carrera de educación física, exigencia del medio by González Orb, Marcelo, Vergara Acevedo, Karla, Salazar Plaza, Felipe, Molina Sotomayor, Edgardo

“…Estudio descriptivo, transversal, orientado a determinar el nivel de conocimiento de contenidos mínimos obligatorios, establecer la correlación, rendimiento…”
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