Search Results - "Aceto, Mario"

l-theanine attenuates abstinence signs in morphine-dependent rhesus monkeys and elicits anxiolytic-like activity in mice by Wise, Laura E., Premaratne, Ishani D., Gamage, Thomas F., Lichtman, Aron H., Hughes, Larry D., Harris, Louis S., Aceto, Mario D.

“…l-theanine, 2-amino-4-(ethylcarbamoyl) butyric acid, an amino acid found in green tea (Camellia sinensis), is sold in the United States as a dietary supplement…”
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Exploring Pharmacological Activities and Signaling of Morphinans Substituted in Position 6 as Potent Agonists Interacting with the μ Opioid Receptor by Haddou, Tanila Ben, Malfacini, Davide, Calo, Girolamo, Aceto, Mario D, Harris, Louis S, Traynor, John R, Coop, Andrew, Schmidhammer, Helmut, Spetea, Mariana

“…Background: Opioid analgesics are the most effective drugs for the treatment of moderate to severe pain. However, they also produce several adverse effects…”
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Pharmacological properties of JDTic: a novel κ-opioid receptor antagonist by Carroll, Ivy, Thomas, James B., Dykstra, Linda A., Granger, Arthur L., Allen, Richard M., Howard, James L., Pollard, Gerald T., Aceto, Mario D., Harris, Louis S.

“…Biological studies were conducted on (3 R)-7-Hydroxy- N-{(1 S)-1-{[(3 R,4…”
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Fumaroylamino-4,5-epoxymorphinans and Related Opioids with Irreversible μ Opioid Receptor Antagonist Effects by Moynihan, Humphrey A, Derrick, Ian, Broadbear, Jillian H, Greedy, Benjamin M, Aceto, Mario D, Harris, Louis S, Purington, Lauren C. S, Thomas, Mark P, Woods, James H, Traynor, John R, Husbands, Stephen M, Lewis, John W

“…We have previously shown that cinnamoyl derivatives of 14β-amino-17-cyclopropylmethyl-7,8-dihydronormorphinone and 7α-aminomethyl-6,14-endoethanonororipavine…”
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NIH 11082 produces anti-depressant-like activity in the mouse tail-suspension test through a delta-opioid receptor mechanism of action by Naidu, Pattipati S., Lichtman, Aron H., Archer, Carey C., May, Everett L., Harris, Louis S., Aceto, Mario D.

“…The present study examined the effects of NIH 11082 ((−)-(1 R,5 R,9 R)-5,9-dimethyl-2′-hydroxy-2-(6-hydroxyhexyl)-6,7-benzomorphan hydrochloride), a…”
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Mixed κ/μ Opioid Receptor Agonists: The 6β-Naltrexamines by Cami-Kobeci, Gerta, Neal, Adrian P, Bradbury, Faye A, Purington, Lauren C, Aceto, Mario D, Harris, Louis S, Lewis, John W, Traynor, John R, Husbands, Stephen M

“…Ligands from the naltrexamine series have consistently demonstrated agonist activity at κ opioid receptors (KOR), with varying activity at the μ opioid…”
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Mixed K/μ Opioid Receptor Agonists : The 6β-Naltrexamines by CAMI-KOBECI, Gerta, NEAL, Adrian P, BRADBURY, Faye A, PURINGTON, Lauren C, ACETO, Mario D, HARRIS, Louis S, LEWIS, John W, TRAYNOR, John R, HUSBANDS, Stephen M

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Effects of JDTic, a selective κ-opioid receptor antagonist, on the development and expression of physical dependence on morphine using a rat continuous-infusion model by Carroll, F. Ivy, Harris, Louis S., Aceto, Mario D.

“…JDTic, (3 R)-7-hydroxy- N-{(1 S)-1-{[(3 R,4…”
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Probes for Narcotic Receptor Mediated Phenomena. 34. Synthesis and Structure−Activity Relationships of a Potent μ-Agonist δ-Antagonist and an Exceedingly Potent Antinociceptive in the Enantiomeric C9-Substituted 5-(3-Hydroxyphenyl)-N-phenylethylmorphan Series by Hiebel, Anne-Cécile, Lee, Yong Sok, Bilsky, Edward, Giuvelis, Denise, Deschamps, Jeffrey R, Parrish, Damon A, Aceto, Mario D, May, Everette L, Harris, Louis S, Coop, Andrew, Dersch, Christina M, Partilla, John S, Rothman, Richard B, Cheng, Kejun, Jacobson, Arthur E, Rice, Kenner C

“…Both of the enantiomers of 5-(3-hydroxyphenyl)-N-phenylethylmorphan with C9α-methyl, C9-methylene, C9-keto, and C9α- and C9β-hydroxy substituents were…”
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Cinnamoyl Derivatives of 7α-Aminomethyl-6,14-endo-ethanotetrahydrothebaine and 7α-Aminomethyl-6,14-endo-ethanotetrahydrooripavine and Related Opioid Ligands by Rennison, David, Neal, Adrian P, Cami-Kobeci, Gerta, Aceto, Mario D, Martinez-Bermejo, Fernando, Lewis, John W, Husbands, Stephen M

“…A new series of ligands has been synthesized where the cinnamoyl group of the 14-cinnamoylamino morphinones has been introduced to the 7α-substituent of the…”
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MDAN-21 : A Bivalent Opioid Ligand Containing mu-Agonist and Delta-Antagonist Pharmacophores and Its Effects in Rhesus Monkeys by Aceto, Mario D., Harris, Louis S., Negus, S. Stevens, Banks, Matthew L., Hughes, Larry D., Akgün, Eyup, Portoghese, Philip S.

“…MDAN-21,…”
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Pharmacological studies with a nonpeptidic, delta-opioid (−)-(1 R,5 R,9 R)-5,9-dimethyl-2′-hydroxy-2-(6-hydroxyhexyl)-6,7-benzomorphan hydrochloride ((−)-NIH 11082) by Aceto, Mario D., May, Everette L., Harris, Louis S., Bowman, Edward R., Cook, Charles D.

“…In the search for a selective delta-opioid receptor agonist, (−)-(1 R,5 R,9 R)-5,9-dimethyl-2′-hydroxy-2-(6-hydroxyhexyl)-6,7-benzomorphan hydrochloride…”
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Effects of the putative antagonist NCS382 on the behavioral pharmacological actions of gammahydroxybutyrate in mice by COOK, Charles D, ACETO, Mario D, COOP, Andrew, BEARDSLEY, Patrick M

“…Gammahydroxybutyrate (GHB) is an endogenous chemical found in the human brain that when administered systemically readily crosses the blood-brain barrier and…”
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Spontaneous and precipitated withdrawal with a synthetic cannabinoid, WIN 55212-2 by Aceto, Mario D, Scates, Susan M, Martin, Billy B

“…Physical dependence on the synthetic cannabinoid-receptor agonist…”
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Characterization of the complex morphinan derivative BU72 as a high efficacy, long-lasting mu-opioid receptor agonist by Neilan, Claire L., Husbands, Stephen M., Breeden, Simon, Ko, M.C. (Holden), Aceto, Mario D., Lewis, John W., Woods, James H., Traynor, John R.

“…The development of buprenorphine as a treatment for opiate abuse and dependence has drawn attention to opioid ligands that have agonist actions followed by…”
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Effect of a 6-Cyano Substituent in 14-Oxygenated N-Methylmorphinans on Opioid Receptor Binding and Antinociceptive Potency by Spetea, Mariana, Greiner, Elisabeth, Aceto, Mario D, Harris, Louis S, Coop, Andrew, Schmidhammer, Helmut

“…In a continued effort to find new substitution patterns in morphinans that would produce strong antinociception while inducing lesser side effects, 4,5-oxygen…”
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Discriminative Stimulus, Reinforcing, Physical Dependence, and Antinociceptive Effects of Oxycodone in Mice, Rats, and Rhesus Monkeys by Beardsley, Patrick M, Aceto, Mario D, Cook, Charles D, Bowman, Edward R, Newman, Jennifer L, Harris, Louis S

“…Despite oxycodone's (4,5-epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one) history of clinical use and the attention it has received as a drug of abuse, few…”
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Effects of Substitution on the Pyrrole N Atom in Derivatives of Tetrahydronaltrindole, Tetrahydrooxymorphindole, and a Related 4,5-Epoxyphenylpyrrolomorphinan by Srivastava, Sanjay K, Shefali, Miller, Carl N, Aceto, Mario D, Traynor, John R, Lewis, John W, Husbands, Stephen M

“…The effect of substitution of the pyrrolo- and indolo-N atoms in tetrahydronaltrindole (TNTI), tetrahydrooxymorphindole (TOMI), and…”
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The influence of esters and carboxylic acids as the N-substituent of opioids. Part 1: Benzomorphans by Metcalf, Matthew D., Aceto, Mario D., Harris, Louis S., Woods, James H., Traynor, John R., Coop, Andrew, May, Everette L.

“…Synthesis and pharmacology of racemic N-ester and N-acid normetazocines. To investigate the effects of carboxylic ester and acid moieties as the N-substituent…”
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Synthesis and Biological Evaluation of 14-Alkoxymorphinans. 21. Novel 4-Alkoxy and 14-Phenylpropoxy Derivatives of the μ Opioid Receptor Antagonist Cyprodime by Spetea, Mariana, Schüllner, Falko, Moisa, Radu C, Berzetei-Gurske, Ilona P, Schraml, Barbara, Dörfler, Cynthia, Aceto, Mario D, Harris, Louis S, Coop, Andrew, Schmidhammer, Helmut

“…The synthesis, biological, and pharmacological evaluation of novel derivatives of cyprodime are described. Their binding affinities at μ, δ, and κ opioid…”
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