Search Results - "Aceña, Jose L."

Chemical Dynamic Thermodynamic Resolution and S/R Interconversion of Unprotected Unnatural Tailor-made α‑Amino Acids by Wang, Shuni, Zhou, Shengbin, Wang, Jiang, Nian, Yong, Kawashima, Aki, Moriwaki, Hiroki, Aceña, José L, Soloshonok, Vadim A, Liu, Hong

“…Described here is an advanced, general method for purely chemical dynamic thermodynamic resolution and S/R interconversion of unprotected tailor-made α-amino…”
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FM19G11, a New Hypoxia-inducible Factor (HIF) Modulator, Affects Stem Cell Differentiation Status by Moreno-Manzano, Victoria, Rodríguez-Jiménez, Francisco J., Aceña-Bonilla, Jose L., Fustero-Lardíes, Santos, Erceg, Slaven, Dopazo, Joaquin, Montaner, David, Stojkovic, Miodrag, Sánchez-Puelles, Jose M.

“…The biology of the α subunits of hypoxia-inducible factors (HIFα) has expanded from their role in angiogenesis to their current position in the self-renewal…”
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Correction to “Chemical Dynamic Thermodynamic Resolution and S/R Interconversion of Unprotected Unnatural Tailor-made α‑Amino Acids” by Wang, Shuni, Zhou, Shengbin, Wang, Jiang, Nian, Yong, Kawashima, Aki, Moriwaki, Hiroki, Aceña, José L, Soloshonok, Vadim A, Liu, Hong

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An Approach to 2,4-Substituted Pyrazolo[1,5-a]pyridines and Pyrazolo[1,5-a]azepines by Ring-Closing Metathesis by Fustero, Santos, Román, Raquel, Asensio, Amparo, Maestro, Miguel A., Aceña, José L., Simón-Fuentes, Antonio

“…The ring‐closing metathesis (RCM) reactions of dienylpyrazoles have been employed in the synthesis of pyrazolo[1,5‐a]pyridine and pyrazolo[1,5‐a]azepine…”
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Biochemical quantitation of the eIF5A hypusination in Arabidopsis thaliana uncovers ABA-dependent regulation by Belda-Palazón, Borja, Nohales, María A, Rambla, José L, Aceña, José L, Delgado, Oscar, Fustero, Santos, Martínez, M Carmen, Granell, Antonio, Carbonell, Juan, Ferrando, Alejandro

“…The eukaryotic translation elongation factor eIF5A is the only protein known to contain the unusual amino acid hypusine which is essential for its biological…”
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Stereocontrolled Total Synthesis of (+)-Altohyrtin A/Spongistatin 1 by Paterson, Ian, Chen, David Y.-K., Coster, Mark J., Aceña, Jose L., Bach, Jordi, Gibson, Karl R., Keown, Linda E., Oballa, Renata M., Trieselmann, Thomas, Wallace, Debra J., Hodgson, Andrew P., Norcross, Roger D.

“…As an exceptionally potent antimitotic macrolide, altohyrtin A/spongistatin 1 shows great promise in cancer chemotherapy but its extreme scarcity in the…”
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Assignment of Absolute Configuration on the Basis of the Conformational Effects Induced by Chiral Derivatizing Agents:  The 2-Arylpyrrolidine Case by Vidal, Paloma, Pedregal, Concepción, Díaz, Nuria, Broughton, Howard, Aceña, José L, Jiménez, Alma, Espinosa, Juan F

“…A novel approach for determining the absolute configuration of a chiral compound is proposed. The methodology is based on the distinct conformational effects…”
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The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: the southern hemisphere EF segment by Paterson, Ian, Coster, Mark J, Chen, David Y-K, Aceña, José L, Bach, Jordi, Keown, Linda E, Trieselmann, Thomas

“…The fully functionalised C29-C51 southern hemisphere of altohyrtin A/spongistatin 1 , incorporating the E- and F-ring tetrahydropyran rings and the unsaturated…”
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Synthesis and biological evaluation of spongistatin/altohyrtin analogues: E-ring dehydration and C46 side-chain truncation by Paterson, Ian, Aceña, Jose L, Bach, Jordi, Chen, David Y K, Coster, Mark J

“…Simplified analogues of the potent antimitotic marine macrolide spongistatin 1/altohyrtin A were synthesised and evaluated as growth inhibitory agents against…”
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Stereocontrolled Total Synthesis of (+)-Altohyrtin A/Spongistatin 1 Financial support was provided by the EPSRC (GR/L41646), Cambridge Commonwealth Trust (Scholarship to M.J.C.), EC (Marie Curie Postdoctoral Fellowship to J.L.A.), DFG (Postdoctoral Fellowship to T.T.), NSERC-Canada (Postdoctoral Fellowship to R.M.O.), Churchill College (Research Fellowship to D.J.W.), Kingapos;s College and Sims Fund, Cambridge (Scholarship to D.Y.K.C.). We also thank Merck and AstraZeneca Pharmaceuticals for ge by Paterson, Ian, Chen, David Y.-K., Coster, Mark J., Aceña, Jose L., Bach, Jordi, Gibson, Karl R., Keown, Linda E., Oballa, Renata M., Trieselmann, Thomas, Wallace, Debra J., Hodgson, Andrew P., Norcross, Roger D.

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The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: fragment couplings, completion of the synthesis, analogue generation and biological evaluation by Paterson, Ian, Chen, David Y-K, Coster, Mark J, Aceña, José L, Bach, Jordi, Wallace, Debra J

“…The antimitotic marine macrolide altohyrtin A/spongistatin 1 has been synthesised in a highly convergent and stereocontrolled manner, thus contributing to the…”
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An Approach to 2,4‐Substituted Pyrazolopyridines and Pyrazoloazepines by Ring‐Closing Metathesis by Santos Fustero, Román, Raquel, Asensio, Amparo, Maestro, Miguel A, Aceña, José L, Antonio Simón‐Fuentes

“…The ring‐closing metathesis (RCM) reactions of dienylpyrazoles have been employed in the synthesis of pyrazolo[1,5‐a]pyridine and pyrazolo[1,5‐a]azepine…”
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Stereocontrolled Total Synthesis of (+)-Altohyrtin A/Spongistatin 1 by Paterson, Ian, Chen, David Y.-K., Coster, Mark J., Aceña, Jose L., Bach, Jordi, Gibson, Karl R., Keown, Linda E., Oballa, Renata M., Trieselmann, Thomas, Wallace, Debra J., Hodgson, Andrew P., Norcross, Roger D.

“…Stark antimitotisch wirksam und darum viel versprechend als Tumortherapeutikum ist das Makrolid Altohyrtin A (Spongistatin 1) 1. Präklinische Studien wurden…”
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