Search Results - "Aceña, J L"

FM19G11 reverses endothelial dysfunction in rat and human arteries through stimulation of the PI3K/Akt/eNOS pathway, independently of mTOR/HIF‐1α activation by El Assar, M, Sánchez‐Puelles, J M, Royo, I, López‐Hernández, E, Sánchez‐Ferrer, A, Aceña, J L, Rodríguez‐Mañas, L, Angulo, J

“…Background and Purpose FM19G11 up‐regulates mammalian target of rapamycin (mTOR)/hypoxia inducible factor‐1α (HIF‐1α) and PI3K/Akt pathways, which are involved…”
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Quantitative analysis of ES-285, an investigational marine anticancer drug, in human, mouse, rat, and dog plasma using coupled liquid chromatography and tandem mass spectrometry by Stokvis, E., Nan-Offeringa, L., Rosing, H., López-Lázaro, L., Aceña, J. L., Miranda, E., Lyubimov, A., Levine, B. S., D'Aleo, C., Schellens, J. H. M., Beijnen, J. H.

“…A method was developed for the quantitative analysis of the novel anticancer agent ES‐285 (spisulosine; free base) in human, mouse, rat, and dog plasma using…”
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FM 19 G 11 reverses endothelial dysfunction in rat and human arteries through stimulation of the PI3K/Akt/eNOS pathway, independently of mTOR / HIF ‐1α activation by El Assar, M, Sánchez‐Puelles, J M, Royo, I, López‐Hernández, E, Sánchez‐Ferrer, A, Aceña, J L, Rodríguez‐Mañas, L, Angulo, J

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Total Synthesis of (+)-7-Deoxypancratistatin from Furan by Aceña, José Luis, Arjona, Odón, León, Ma Luisa, Plumet, Joaquín

“…A new total synthesis of (+)-7-deoxypancratistatin 1 has been accomplished in 19 steps (8% overall yield) from two readly available compounds, furan and…”
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Total Syntheses of (±)-Cyclophellitol and (1R,6S)-Cyclophellitol by Aceña, José Luis, Arjona, Odón, Plumet, Joaquín

“…A stereodivergent synthesis of (±)-cyclophellitol (1) and its unnatural diastereoisomer (1R*,6S*)-cyclophellitol (2), starting from the Diels−Alder adduct of…”
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Studies in Marine Polypropionate Synthesis:  Total Synthesis of (−)-Baconipyrone C by Paterson, Ian, Chen, David Yu-Kai, Aceña, José Luis, Franklin, Alison S

“…An asymmetric total synthesis of the unusual siphonariid metabolite, (−)-baconipyrone C (3), is described. Key steps included a tin(II)-mediated aldol coupling…”
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FM19G11 reverses endothelial dysfunction in rat and human arteries through stimulation of the PI3K/Akt/eNOS pathway, independently of mTOR/HIF-1[alpha] activation by El Assar, M, Sanchez-Puelles, J M, Royo, I, Lopez-Hernandez, E, Sanchez-Ferrer, A, Acena, J L, Rodriguez-Manas, L, Angulo, J

“…Background and Purpose FM19G11 up-regulates mammalian target of rapamycin (mTOR)/hypoxia inducible factor-1[alpha] (HIF-1[alpha]) and PI3K/Akt pathways, which…”
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Strain-directed bridge cleavage of (phenylsulfonyl)-7-oxabicyclo[2.2.1]heptane derivatives: application to the total synthesis of carba-.alpha.-DL-glucopyranose by Acena, Jose Luis, Arjona, Odon, Fernandez de la Pradilla, Roberto, Plumet, Joaquin, Viso, Alma

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Role of the gem-Difluoro Moiety in the Tandem Ring-Closing Metathesis−Olefin Isomerization:  Regioselective Preparation of Unsaturated Lactams by FUSTERO, Santos, SáNCHEZ-ROSELLó, María, JIMéNEZ, Diego, SANZ-CERVERA, Juan F., DEL POZO, Carlos, ACEñA, José Luis

“…Careful selection of the metathesis catalyst, solvent, and reaction conditions allows for the efficient and regioselective synthesis of isomeric fluorinated…”
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Fluorous (Trimethylsilyl)ethanol:  A New Reagent for Carboxylic Acid Tagging and Protection in Peptide Synthesis by Fustero, Santos, Sancho, Amador García, Chiva, Gema, Sanz-Cervera, Juan F, del Pozo, Carlos, Aceña, José Luis

“…Starting with a fluorous analogue of 2-(trimethylsilyl)ethanol, we have designed an easy method for preparing a new fluorous tag (FTMSE) for the protection of…”
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Stereocontrolled Total Synthesis of (+)-Altohyrtin A/Spongistatin 1 by Paterson, Ian, Chen, David Y.-K., Coster, Mark J., Aceña, Jose L., Bach, Jordi, Gibson, Karl R., Keown, Linda E., Oballa, Renata M., Trieselmann, Thomas, Wallace, Debra J., Hodgson, Andrew P., Norcross, Roger D.

“…As an exceptionally potent antimitotic macrolide, altohyrtin A/spongistatin 1 shows great promise in cancer chemotherapy but its extreme scarcity in the…”
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The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: fragment couplings, completion of the synthesis, analogue generation and biological evaluation by Paterson, Ian, Chen, David Y-K, Coster, Mark J, Aceña, José L, Bach, Jordi, Wallace, Debra J

“…The antimitotic marine macrolide altohyrtin A/spongistatin 1 has been synthesised in a highly convergent and stereocontrolled manner, thus contributing to the…”
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Synthesis and Biological Evaluation of New Bicyclic Fluorinated Uracils through Ring-Closing Metathesis by Fustero, Santos, Catalán, Silvia, Piera, Julio, Sanz-Cervera, Juan F, Fernández, Begoña, Aceña, José Luis

“…Two families of bicyclic fluorinated uracils have been prepared starting from a gem-difluorinated unsaturated nitrile, by means of a ring-closing metathesis…”
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The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: the southern hemisphere EF segment by Paterson, Ian, Coster, Mark J, Chen, David Y-K, Aceña, José L, Bach, Jordi, Keown, Linda E, Trieselmann, Thomas

“…The fully functionalised C29-C51 southern hemisphere of altohyrtin A/spongistatin 1 , incorporating the E- and F-ring tetrahydropyran rings and the unsaturated…”
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Synthesis and biological evaluation of spongistatin/altohyrtin analogues: E-ring dehydration and C46 side-chain truncation by Paterson, Ian, Aceña, Jose L, Bach, Jordi, Chen, David Y K, Coster, Mark J

“…Simplified analogues of the potent antimitotic marine macrolide spongistatin 1/altohyrtin A were synthesised and evaluated as growth inhibitory agents against…”
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Unexpected One-Pot Epoxy Sulfone−Enaminone Transformation. Synthesis of 5a-Carba-β-mannopyranosylamine by Aceña, José Luis, Arjona, Odón, Mañas, Rosa, Plumet, Joaquín

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New fluorinated 1,3-vinylogous amidines as versatile intermediates: synthesis of fluorinated pyrimidin-2(1 H)-ones by Fustero, Santos, Piera, Julio, Sanz-Cervera, Juan F., Román, Raquel, Brodsky, Benjamin H., Sánchez-Roselló, María, Aceña, José Luis, Ramírez de Arellano, Carmen

“…The condensation of the azaenolates derived from readily available ketimines with fluorinated nitriles offers an efficient and straightforward entry to new…”
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Polypropionates from 7-oxanorbornene derivatives. A stereoselective and divergent synthesis of fragments with four contiguous chiral centers by Aceña, José Luis, Arjona, Odón, León, Marisa, Plumet, Joaquín

“…The epimeric stereotetrads 12 and 14 have been prepared starting from the Diels-Alder endo adduct of furan and acrylic acid. The key steps of the route were…”
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A convenient approach to the aminocyclitol fragment of pancratistatin from 7-oxanorbornenes by Aceña, JoséLuis, Arjona, Odón, Iradier, Fátima, Plumet, Joaquín

“…A totally stereoselective route to an analogue aminocyclitol fragment of the alkaloid pancratistatin has been achieved starting from a 7-oxanorbornenic…”
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Total synthesis of (+)-pinitol by Aceña, JoséLuis, Arjona, Odón, Plumet, Joaquín

“…A new synthesis of (+)-pinitol 9 has been developed starting from the 7-oxanorbornenic sulfone (+)- 5, prepared in enantiomerically pure form by resolution of…”
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